Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Mark T. Ziolo"'
Autor:
Kelsey M. Pinckard, Elisa Félix-Soriano, Shanna Hamilton, Radmila Terentyeva, Lisa A. Baer, Katherine R. Wright, Drew Nassal, Joao Victor Esteves, Eaman Abay, Vikram K. Shettigar, Mark T. Ziolo, Thomas J. Hund, Loren E. Wold, Dmitry Terentyev, Kristin I. Stanford
Publikováno v:
Molecular Metabolism, Vol 82, Iss , Pp 101914- (2024)
Objective: The intrauterine environment during pregnancy is a critical factor in the development of obesity, diabetes, and cardiovascular disease in offspring. Maternal exercise prevents the detrimental effects of a maternal high fat diet on the meta
Externí odkaz:
https://doaj.org/article/43233158c48a4f618c81e1532dc8152a
Autor:
Arden B. Piepho, Jeovanna Lowe, Laurel R. Cumby, Lisa E. Dorn, Dana M. Lake, Neha Rastogi, Megan D. Gertzen, Sarah L. Sturgill, Guy L. Odom, Mark T. Ziolo, Federica Accornero, Jeffrey S. Chamberlain, Jill A. Rafael-Fortney
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 344-354 (2023)
Micro-dystrophin gene replacement therapies for Duchenne muscular dystrophy (DMD) are currently in clinical trials, but have not been thoroughly investigated for their efficacy on cardiomyopathy progression to heart failure. We previously validated F
Externí odkaz:
https://doaj.org/article/112376132c914e0588ee19091b2c6a91
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
For years, ejection fraction has been an essentially ubiquitous measurement for assessing the cardiovascular function of animal models in research labs. Despite technological advances, it remains the top choice among research labs for reporting heart
Externí odkaz:
https://doaj.org/article/0c244a14b56b4655a07d12e0863ec417
Autor:
Jennifer M. Peterson, David J. Wang, Vikram Shettigar, Steve R. Roof, Benjamin D. Canan, Nadine Bakkar, Jonathan Shintaku, Jin-Mo Gu, Sean C. Little, Nivedita M. Ratnam, Priya Londhe, Leina Lu, Christopher E. Gaw, Jennifer M. Petrosino, Sandya Liyanarachchi, Huating Wang, Paul M. L. Janssen, Jonathan P. Davis, Mark T. Ziolo, Sudarshana M. Sharma, Denis C. Guttridge
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function throug
Externí odkaz:
https://doaj.org/article/aa724b3e4c7b4ada9b67a708841b1195
Autor:
Vikram Shettigar, Bo Zhang, Sean C. Little, Hussam E. Salhi, Brian J. Hansen, Ning Li, Jianchao Zhang, Steve R. Roof, Hsiang-Ting Ho, Lucia Brunello, Jessica K. Lerch, Noah Weisleder, Vadim V. Fedorov, Federica Accornero, Jill A. Rafael-Fortney, Sandor Gyorke, Paul M. L. Janssen, Brandon J. Biesiadecki, Mark T. Ziolo, Jonathan P. Davis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Heart contraction, which is decreased in disease, is determined by Ca2+binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Tropo
Externí odkaz:
https://doaj.org/article/9828c585327046c3b5306a0cb5e0d215
Autor:
Steve R. Roof, Yukie Ueyama, Reza Mazhari, Robert L. Hamlin, J. Craig Hartman, Mark T. Ziolo, John E. Reardon, Carlos L. del Rio
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
The nitroxyl (HNO) prodrug, CXL-1020, induces vasorelaxation and improves cardiac function in canine models and patients with systolic heart failure (HF). HNO's unique mechanism of action may be applicable to a broader subset of cardiac patients. Thi
Externí odkaz:
https://doaj.org/article/3b8b471a543e49efbf76a4770d5c30ff
Autor:
Vineeta Tanwar, Matthew W. Gorr, Markus Velten, Clayton M. Eichenseer, Victor P. Long, Ingrid M. Bonilla, Vikram Shettigar, Mark T. Ziolo, Jonathan P. Davis, Stephen H. Baine, Cynthia A. Carnes, Loren E. Wold
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 4 (2017)
BackgroundParticulate matter (PM; PM2.5 [PM with diameters of
Externí odkaz:
https://doaj.org/article/8834cc780b87467b95f629cf680a40a2
Autor:
Kenneth D. Varian, Brandon J. Biesiadecki, Mark T. Ziolo, Jonathan P. Davis, Paul M. L. Janssen
Publikováno v:
Biochemistry Research International, Vol 2012 (2012)
Myofilament calcium sensitivity decreases with frequency in intact healthy rabbit trabeculae and associates with Troponin I and Myosin light chain-2 phosphorylation. We here tested whether serine-threonine kinase activity is primarily responsible for
Externí odkaz:
https://doaj.org/article/0873217444fb4717935e55997733cb36
Autor:
Hussam E. Salhi, Vikram Shettigar, Lorien Salyer, Sarah Sturgill, Elizabeth A. Brundage, Joel Robinett, Zhaobin Xu, Eaman Abay, Jeovanna Lowe, Paul M.L. Janssen, Jill A. Rafael-Fortney, Noah Weisleder, Mark T. Ziolo, Brandon J. Biesiadecki
Publikováno v:
Journal of Molecular and Cellular Cardiology. 176:84-96
Autor:
Hesham Kelani, Kara Corps, Sarah Mikula, Lesley C. Fisher, Mahmoud T. Shalaan, Sarah Sturgill, Mark T. Ziolo, Mahmoud Abdel-Rasoul, D. Michele Basso, Hamdy Awad
Publikováno v:
Anesthesiology. 138:403-419
BackgroundA clinically relevant mouse model of thoracic endovascular aortic repair–induced ischemic spinal cord injury has been lacking since the procedure was first employed in 1991. The hypothesis was that ligation of mouse intercostal arteries w