Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Mark T. Mc Auley"'
Autor:
Mark T. Mc Auley
Publikováno v:
Experimental Gerontology, Vol 179, Iss , Pp 112256- (2023)
In the last decade epigenetics has come to the fore as a discipline which is central to biogerontology. Age associated epigenetic changes are routinely linked with pathologies, including cardiovascular disease, cancer, and Alzheimer's disease; moreov
Externí odkaz:
https://doaj.org/article/b423180570de4d3cbabeb9565ec9df6e
Publikováno v:
Biology, Vol 12, Iss 8, p 1133 (2023)
Cardiovascular disease (CVD) is the leading cause of death globally. The underlying pathological driver of CVD is atherosclerosis. The primary risk factor for atherosclerosis is elevated low-density lipoprotein cholesterol (LDL-C). Dysregulation of c
Externí odkaz:
https://doaj.org/article/fa8f99560ca44693937ffee3041c9460
Publikováno v:
Metabolites, Vol 5, Iss 2, Pp 232-251 (2015)
The underlying cellular mechanisms that characterize aging are complex and multifaceted. However, it is emerging that aging could be regulated by two distinct metabolic hubs. These hubs are the pathway defined by the mammalian target of rapamycin (mT
Externí odkaz:
https://doaj.org/article/4469575812764f08a04f299787e2abe5
Autor:
Mark T. Mc Auley, Kathleen M. Mooney
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 13, Iss C, Pp 38-46 (2015)
One of the greatest challenges in biology is to improve the understanding of the mechanisms which underpin aging and how these affect health. The need to better understand aging is amplified by demographic changes, which have caused a gradual increas
Externí odkaz:
https://doaj.org/article/85aac1221053431c8794d6531251285a
Autor:
Mark T. Mc Auley
Publikováno v:
Mechanisms of ageing and development. 208
Dietary restriction (DR) represents one of the most robust interventions for extending lifespan. It is not known how DR increases lifespan. The prevailing evolutionary hypothesis suggests the DR response redirects metabolic resources towards somatic
Autor:
Luis G. Aguayo, Marium Ahmed, Mohamed H. Ahmed, Musaab Ahmed, Hélio M.T. Albuquerque, Alicia Alonso, Rana Ashkar, Fodil Azzaz, Carlos J. Baier, Francisco J. Barrantes, Małgorzata Bednarska-Makaruk, Andrew S. Bell, Asier Benito-Vicente, Michael F. Brown, Anna N. Bukiya, Carlos F. Burgos, Henri Chahinian, Waranya Chatuphonprasert, Parkson Lee-Gau Chong, Arrigo F.G. Cicero, Ivan R. Cincione, Tatiana M. Clemente, George A. Cook, Zoe Cournia, Coralie Di Scala, Milka Doktorova, Fathima T. Doole, Alex M. Dopico, Alexandros A. Drosos, Hong Du, Marshall B. Elam, Isabella Ellinger, Jacques Fantini, Filipe Ferrari, Unai Galicia-Garcia, Aritz B. García-Arribas, Stacey D. Gilk, Félix M. Goñi, Juliana Gonzalez-Sanmiguel, Gregory A. Grabowski, Sudipta Gupta, Tina Herfel, DanRong Hu, Juyang Huang, Shifa Jebari-Benslaiman, Qiu-Xing Jiang, Samantha Karr, George Khelashvili, Sofia Kiriakidi, Tamas Kovacs, Teshani Kumarage, Claude K. Lardinois, Asier Larrea-Sebal, Irena Levitan, Hanxuan Li, Wei Li, Falk W. Lohoff, Agnieszka Ługowska, Cesar Martin, Vítor M. Martins, Thomas Mavromoustakos, Mark T. Mc Auley, Dushyant Mital, Bob M. Moore, Amy E. Morgan, Ole G. Mouritsen, Steven Mysiewicz, Kelsey C. North, Emma M. O’Connell, Marta Pasenkiewicz-Gierula, ZhiYong Qian, Jorge P. Roa, Avia Rosenhouse-Dantsker, Clementina M.M. Santos, Artur M.S. Silva, Alexandria Slayden, Ghada A. Soliman, Natalia Stein, Ricardo Stein, Witold K. Subczynski, István P. Sugár, Lajos Szente, Kepa B. Uribe, Zoltan Varga, Aliki I. Venetsanopoulou, Paraskevi V. Voulgari, Francine K. Welty, Justyna Widomska, Nouara Yahi, Zdenek Zadak, Florina Zakany
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b40991fd39b691490fd3a3998572c24a
https://doi.org/10.1016/b978-0-323-85857-1.09991-0
https://doi.org/10.1016/b978-0-323-85857-1.09991-0
Autor:
Mark T. Mc Auley
Publikováno v:
Nutrition Research Reviews. 33:121-133
The last few decades have witnessed a global rise in the number of older individuals. Despite this demographic shift, morbidity within this population group is high. Many factors influence healthspan; however, an obesity pandemic is emerging as a sig
Publikováno v:
Experimental gerontology. 156
Due to its complexity and its ubiquitous nature the ageing process remains an enduring biological puzzle. Many molecular mechanisms and biochemical process have become synonymous with ageing. However, recent findings have pinpointed epigenetics as ha
Autor:
Loukas Zagkos, Anastasios Matzavinos, Jason A. Roberts, Nikos I. Kavallaris, Mark T. Mc Auley, Karen Larson
Publikováno v:
Journal of Theoretical Biology. 467:87-99
Epigenetics is coming to the fore as a key process which underpins health. In particular emerging experimental evidence has associated alterations to DNA methylation status with healthspan and aging. Mammalian DNA methylation status is maintained by