Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mark T. Livesay"'
Autor:
Jay T. Evans, Laura S. Bess, Sandra C. Mwakwari, Mark T. Livesay, Yufeng Li, Van Cybulski, David A. Johnson, Hélène G. Bazin
Publikováno v:
ACS Omega, Vol 4, Iss 13, Pp 15665-15677 (2019)
Externí odkaz:
https://doaj.org/article/57a66b2a20fa4bed84c6fd25ad0c1c48
Autor:
Shannon M. Miller, Van Cybulski, Margaret Whitacre, Laura S. Bess, Mark T. Livesay, Lois Walsh, David Burkhart, Hélène G. Bazin, Jay T. Evans
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Most licensed seasonal influenza vaccines are non-adjuvanted and rely primarily on vaccine-induced antibody titers for protection. As such, seasonal antigenic drift and suboptimal vaccine strain selection often results in reduced vaccine efficacy. Fu
Externí odkaz:
https://doaj.org/article/f8c158556d2845698014a963a9729949
Autor:
Yufeng Li, Laura S. Bess, David A. Johnson, Sandra C. Mwakwari, Mark T. Livesay, Jay T. Evans, Van Cybulski, Hélène G. Bazin
Publikováno v:
ACS Omega, Vol 4, Iss 13, Pp 15665-15677 (2019)
ACS Omega
ACS Omega
Toll-like receptors 7 and 8 (TLR7/8) are broadly expressed on antigen-presenting cells, making TLR7/8 agonists likely candidates for the development of new vaccine adjuvants. We previously reported the synthesis of a new series of 8-oxoadenines subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2ef3a0afc9427009a2a6ef6405faec
https://doaj.org/article/57a66b2a20fa4bed84c6fd25ad0c1c48
https://doaj.org/article/57a66b2a20fa4bed84c6fd25ad0c1c48
Publikováno v:
Organic Preparations and Procedures International. 50:109-244
Imidazoquinolines are heterocylic scaffolds resulting from the fusion between the 5-membered ring imidazole and the benzopyridine ring, quinoline (Figure 1). Such fused systems retain some properti...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21336f80a44e4e0730d2d8f794538e6b
https://doi.org/10.1080/00304948.2018.1433427
https://doi.org/10.1080/00304948.2018.1433427
Autor:
Shannon M. Miller, Van Cybulski, Margaret Whitacre, Laura S. Bess, Mark T. Livesay, Lois Walsh, David Burkhart, Hélène G. Bazin, Jay T. Evans
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Most licensed seasonal influenza vaccines are non-adjuvanted and rely primarily on vaccine-induced antibody titers for protection. As such, seasonal antigenic drift and suboptimal vaccine strain selection often results in reduced vaccine efficacy. Fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedb26f951905e69817859031bb51e4b
https://pubmed.ncbi.nlm.nih.gov/32210973
https://pubmed.ncbi.nlm.nih.gov/32210973
Publikováno v:
Tetrahedron Lett
A high-yielding and scalable phosphoramidite procedure was developed for the phospholipidation of TLR7/8-active imidazoquinolines. This method involves the reaction of a 1,2-diacyl- or dialkyl-sn-glycerol or 3-chlolesterylalkanol with 2-cyanoethyl N,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b74ddfc198ceace2eec16424150d70
https://doi.org/10.1016/j.tetlet.2016.03.091
https://doi.org/10.1016/j.tetlet.2016.03.091
Autor:
Hélène G. Bazin, Yufeng Li, David A. Johnson, Shannon M. Miller, Jay T. Evans, Mark T. Livesay, Van Cybulski, Laura S. Bess
Publikováno v:
Bioorg Med Chem Lett
Toll-like receptors 7 and 8 (TLR7/8) agonists are potent immunostimulants that are attracting considerable interest as vaccine adjuvants. We recently reported the synthesis of a new series of 2-O-butyl-8-oxoadenines substituted at the 9-position with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfd0814c1ca5a00ac187db92701d377
https://doi.org/10.1016/j.bmcl.2020.126984
https://doi.org/10.1016/j.bmcl.2020.126984
Autor:
Hélène G. Bazin, Craig L. Johnson, Steven P. Fling, Mark T. Livesay, William S. Bowen, Tim J. Murray, Afsaneh Mozaffarian, Johnson David A, Laura S. Bess, Kendal T. Ryter, Cluff Christopher W, Jeffrey S. Arnold, Jay T. Evans
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5350-5354
To overcome the chemical and metabolic instability of the secondary fatty acyl residues in the AGP class of lipid A mimetics, the secondary ether lipid analogs of the potent TLR4 agonist CRX-527 (2) and TLR4 antagonist CRX-526 (3) were synthesized an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26336b5880d479f03de5bf3b9b911321
https://doi.org/10.1016/j.bmcl.2008.09.060
https://doi.org/10.1016/j.bmcl.2008.09.060
Autor:
Johnson David A, Kendal T. Ryter, Hélène G. Bazin, Jeffrey S. Arnold, Craig L. Johnson, Mark T. Livesay, Laura S. Bess
Publikováno v:
Tetrahedron Letters. 47:2087-2092
An efficient and scalable synthesis of the potent vaccine adjuvant RC-529 ( 3 ) and TLR4 agonist CRX-524 ( 4 ) is described in eight steps from 1,3,4,6-tetra-O-acetyl-2-amino-2-benzyloxycarbonyl-2-deoxy-β- d -glucopyranose ( 10c ) in ca. 25% overall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f30a985e3205fe513542a65db9e53b50
https://doi.org/10.1016/j.tetlet.2006.01.137
https://doi.org/10.1016/j.tetlet.2006.01.137
Autor:
Jay T. Evans, Johnson David A, Hélène G. Bazin, Juhienah K. Khalaf, Yufeng Li, Mark T. Livesay, Sandra C. Mwakwari
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(6)
We report the synthesis and biological evaluation of a new series of 8-oxoadenines substituted at the 9-position with a 4-piperidinylalkyl moiety. In vitro evaluation of the piperidinyl-substituted oxoadenines 3a–g in human TLR7- or TLR8-transfecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9704b9cfeb37cd3eab1386a7bb3212f
https://pubmed.ncbi.nlm.nih.gov/25698055
https://pubmed.ncbi.nlm.nih.gov/25698055