Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Mark T. J. van Bussel"'
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Akademický článek
Intracranial antitumor responses of nivolumab and ipilimumab: a pharmacodynamic and pharmacokinetic perspective, a scoping systematic review
Autor: Mark T. J. van Bussel, Jos H. Beijnen, Dieta Brandsma
Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background Recently, two phase II trials showed intracranial activity of the immune checkpoint inhibitors nivolumab and ipilimumab in patients with melanoma brain metastases. However, it is generally assumed that large molecules like monoclo
Externí odkaz: https://doaj.org/article/1cdc15cf6d6e4975a597b4da7c1244ef
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2
A Phase Ib/II Study of WNT974 + Encorafenib + Cetuximab in Patients With BRAF V600E-Mutant KRAS Wild-Type Metastatic Colorectal Cancer
Autor: Josep Tabernero, Eric Van Cutsem, Elena Garralda, David Tai, Filippo De Braud, Ravit Geva, Mark T J van Bussel, Katia Fiorella Dotti, Elena Elez, María J de Miguel, Kevin Litwiler, Danielle Murphy, Michelle Edwards, Van Karlyle Morris
Publikováno v: Scientia
Background WNT974 is a small molecule inhibitor of Wnt signaling that specifically inhibits porcupine O-acyltransferase. This phase Ib dose-­escalation study evaluated the maximum tolerated dose of WNT974 in combination with encorafenib and cetuxima
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5f044abd821df8649f422f22924992
https://doi.org/10.1093/oncolo/oyad007
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A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours
Autor: Mirjam Kuipers, Ivan Diaz-Padilla, Morten Mau-Sørensen, Barbara Sarholz, Maja J.A. de Jonge, Dorte Nielsen, Ahmad Awada, Henk M.W. Verheul, Karin Berghoff, Jan H.M. Schellens, Lars Damstrup, Samer El Bawab, Patrick Schöffski, Mark T. J. van Bussel
Publikováno v: British Journal of Cancer, 124, 728-735
van Bussel, M T J, Awada, A, de Jonge, M J A, Mau-Sørensen, M, Nielsen, D, Schöffski, P, Verheul, H M W, Sarholz, B, Berghoff, K, El Bawab, S, Kuipers, M, Damstrup, L, Diaz-Padilla, I & Schellens, J H M 2021, ' A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours ', British Journal of Cancer, vol. 124, no. 4, pp. 728-735 . https://doi.org/10.1038/s41416-020-01151-6
British Journal of Cancer
British Journal of Cancer, 124, 4, pp. 728-735
Background: This open-label, phase 1 trial (NCT02316197) aimed to determine the maximum-tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of peposertib (formerly M3814), a DNA-dependent protein kinase (DNA-PK) inhibitor in patients with adv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a65e8cb8640861d31d96ecf577c12d9
https://hdl.handle.net/2066/232010
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6
EpCAM-based assays for epithelial tumor cell detection in cerebrospinal fluid
Autor: Dieta Brandsma, Dick Pluim, Mark T. J. van Bussel, Jos H. Beijnen, Jan H.M. Schellens, Mijke Bol
Publikováno v: Journal of Neuro-Oncology, 137(1), 1. Kluwer Academic Publishers
The diagnosis of leptomeningeal metastases (LM) of solid tumors is complicated due to low sensitivities of both magnetic resonance imaging (MRI) and cytology. MRI has a sensitivity of 76% for the diagnosis of LM and cerebrospinal fluid (CSF) cytology
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942d20e29bd9cf61cbe7effa6e068493
https://doi.org/10.1007/s11060-017-2691-6
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7
Circulating epithelial tumor cell analysis in CSF in patients with leptomeningeal metastases
Autor: Bojana Milojkovic Kerklaan, Jos H. Beijnen, Dick Pluim, Daan van den Broek, Mijke Bol, Mark T. J. van Bussel, Dieta Brandsma, Dorothe Linders, Jan H.M. Schellens, Karolina Sikorska
Publikováno v: Neurology. 94(5)
ObjectiveThe primary objective was to determine the sensitivity and specificity of epithelial cell adhesion molecule (EpCAM) immunoflow cytometry circulating tumor cells (CTC) analysis in CSF in patients with suspected leptomeningeal metastases (LM).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc2394c21752182914a1ca86123dcb2
https://pubmed.ncbi.nlm.nih.gov/31907288
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9
CMET-12. TUMOR CELL DETECTION BY IMMUNOFLOW CYTOMETRY AND BRAF MUTATION ANALYSIS IN CEREBROSPINAL FLUID OF MELANOMA PATIENTS WITH SUSPECTED LEPTOMENINGEAL METASTASES
Autor: Dick Pluim, Mark T. J. van Bussel, Bojana Milojkovic-Kerklaan, Jan H.M. Schellens, Emilie Le Rhun, Daan van den Broek, Dieta Brandsma, Jos H. Beijnen, Willem Boogerd
Publikováno v: Neuro-Oncology. 19:vi41-vi41
INTRODUCTION Approximately five percent of melanoma patients develop leptomeningeal metastases (LM). Diagnosis of LM can be made on clinical symptoms and typical contrast enhancement of the leptomeninges on MRI brain or spine and/or CSF cytology. How
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8f444071174f160ac94107a96fe31f
https://doi.org/10.1093/neuonc/nox168.161
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