Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Mark T. Fisher"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Translocation is essential to the anthrax toxin mechanism. Protective antigen (PA), the binding component of this AB toxin, forms an oligomeric pore that translocates lethal factor (LF) or edema factor, the active components of the toxin, in
Externí odkaz:
https://doaj.org/article/3f8e058c49e347208faec432f78c2113
Autor:
Pierce T. O'Neil, Alexandra J. Machen, Benjamin C. Deatherage, Caleb Trecazzi, Alexander Tischer, Venkata R. Machha, Matthew T. Auton, Michael R. Baldwin, Tommi A. White, Mark T. Fisher
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
The nucleotide-free chaperonin GroEL is capable of capturing transient unfolded or partially unfolded states that flicker in and out of existence due to large-scale protein dynamic vibrational modes. In this work, three short vignettes are presented
Externí odkaz:
https://doaj.org/article/a870c8a57acf4a8c80dd837c14933afb
Publikováno v:
Biomolecules, Vol 4, Iss 4, Pp 956-979 (2014)
Numerous human diseases are caused by protein folding defects where the protein may become more susceptible to degradation or aggregation. Aberrant protein folding can affect the kinetic stability of the proteins even if these proteins appear to be s
Externí odkaz:
https://doaj.org/article/8a3f51eafb1e4bbf800f8cce5320ae93
Autor:
Alexandra J. Machen, Narahari Akkaladevi, Caleb Trecazzi, Pierce T. O’Neil, Srayanta Mukherjee, Yifei Qi, Rebecca Dillard, Wonpil Im, Edward P. Gogol, Tommi A. White, Mark T. Fisher
Publikováno v:
Toxins, Vol 9, Iss 10, p 298 (2017)
The anthrax lethal toxin consists of protective antigen (PA) and lethal factor (LF). Understanding both the PA pore formation and LF translocation through the PA pore is crucial to mitigating and perhaps preventing anthrax disease. To better understa
Externí odkaz:
https://doaj.org/article/fede19d32f3a48ffa74c7d3b15e73737
Autor:
Matthew J. McLaughlin, Mark T. Fisher
Publikováno v:
Journal of Pediatric Rehabilitation Medicine. 16:3-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7f92ff512e2c4d52661a76fc30a1ae9
https://doi.org/10.3233/prm-230003
https://doi.org/10.3233/prm-230003
Autor:
Denesh Ratnasingam, Sathya Vadivelu, Mark T Fisher, Emily McGhee, Justin Ramsey, Matthew J. McLaughlin, Kim Hartman
Publikováno v:
Journal of pediatric rehabilitation medicine. 13(3)
PURPOSE: After the onset of the Coronavirus pandemic of 2019–2020 (COVID-19), physicians who inject OnabotulinumtoxinA (BoNT-A) were left with determining risks and benefits in pediatric patients with cerebral palsy. Many of these patients have pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c20fb70e5603df821466e3d2dab66c
https://pubmed.ncbi.nlm.nih.gov/33252098
https://pubmed.ncbi.nlm.nih.gov/33252098
Publikováno v:
Journal of Pediatric Rehabilitation Medicine. 11:193-197
PURPOSE To evaluate variables that modulate pain during intramuscular botulinum toxin A injections in children. METHODS As part of a Quality Improvement project, this retrospective analysis compared reported pain during and five minutes post injectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb61e727fd33d9be402766903f7b179
https://doi.org/10.3233/prm-170516
https://doi.org/10.3233/prm-170516
Autor:
Mark T. Fisher, C.R. Middaugh, Samantha E. Pace, Reza Esfandiary, Sangeeta B. Joshi, Steven M. Bishop, David B. Volkin, Robert Stadelman
Publikováno v:
Journal of Pharmaceutical Sciences. 107:559-570
An automated method using biotinylated GroEL-streptavidin biosensors with biolayer interferometry (GroEL-BLI) was evaluated to detect the formation of transiently formed, preaggregate species in various pharmaceutically relevant monoclonal antibody (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16eb4ac3f94e47d3cfffe81363e31313
https://doi.org/10.1016/j.xphs.2017.10.010
https://doi.org/10.1016/j.xphs.2017.10.010
Autor:
Erin M. Shriver, Nitin A. Pagedar, William W. Terry, Mark T Fisher, Caroline W Wilson, Gretchen Kass
Publikováno v:
Ophthalmic Plastic & Reconstructive Surgery. 35:e122-e124
The aim of exenteration reconstruction is to stabilize the postsurgical wound bed to promote expeditious healing particularly in patients who are undergoing adjuvant radiation and/or chemotherapy. Porcine urinary bladder matrix has previously been us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29aa96da922b31c6ebd4503b4e2e156
https://doi.org/10.1097/iop.0000000000001453
https://doi.org/10.1097/iop.0000000000001453
Autor:
Alexandra J Machen, Mark T. Fisher, Wendy A. Lea, Karen R. Khar, Matthew Auton, Alexander Tischer, Pierce T. O’Neil, Subhashchandra Naik, Tapan Chaudhri, Wesley Mcginn-Straub, John Karanicolas, Joshua R. Burns, Michael R. Baldwin
Publikováno v:
Biochemistry. 55:4885-4908
Stabilizing the folded state of metastable and/or aggregation-prone proteins through exogenous ligand binding is an appealing strategy for decreasing disease pathologies caused by protein folding defects or deleterious kinetic transitions. Current me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96424c6b9eef2d3519b3cee8899fe9ed
https://doi.org/10.1021/acs.biochem.6b00293
https://doi.org/10.1021/acs.biochem.6b00293