Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mark T. DuPriest"'
Autor:
Paul W Zinke, Mark T. DuPriest, Steven J. Sproull, Deason Michael E, and Anura P. Dantanarayana, W. Dennis Dean, Raymond E. Conrow
Publikováno v:
Organic Process Research & Development. 3:114-120
A large scale synthesis of the topical carbonic anhydrase inhibitors AL-4623A (13a·HCl) and AL-4862 (13b) from 3-acetyl-2,5-dichlorothiophene (“DCAT”, 1) is described. Reaction of 1 with NaSBn gave thioether 2, which was converted via sulfenyl c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e7e4e28388cc773425289d0f575f193
https://doi.org/10.1021/op9802125
https://doi.org/10.1021/op9802125
Autor:
and Anura P. Dantanarayana, Daniel Kuzmich, Steven J. Sproull, Paul W Zinke, Raymond E. Conrow, Mark T. DuPriest
Publikováno v:
The Journal of Organic Chemistry. 62:9372-9375
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ebf216395e02581fc193e229355cd18
https://doi.org/10.1021/jo971550r
https://doi.org/10.1021/jo971550r
Autor:
Young Han Park, Billie M. York, John T. Slattery, Brenda W. Griffin, Philip R. Mayer, Ronnie Barker, Gary W. Williams, Mark T. DuPriest
Publikováno v:
Pharmaceutical Research. 10:593-597
The pharmacokinetics of AL03152 (RS) and its enantiomers, AL03802 (R) and AL03803 (S), were studied in the Sprague–Dawley rat following intravenous bolus administration. The enantiomers had differing pharmacokinetic profiles, while the racemic comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::529e0f393f947a5d45658dc5a806d4ec
https://doi.org/10.1023/a:1018962405911
https://doi.org/10.1023/a:1018962405911
Publikováno v:
ChemInform. 22
The benzyl imines of several fluorenones were treated with base, followed by methyl chloroformate, to introduce the carbomethoxy group at the 9-fluorenyl position. Imine hydrolysis afforded the title compounds. The reaction was readily conducted on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dd18ddce72ada98194ac694c882d891
https://doi.org/10.1002/chin.199123130
https://doi.org/10.1002/chin.199123130
Publikováno v:
ChemInform. 23
The first examples of spiro[fluorene-9,4'- and -9,5'-isothiazolidin]one dioxides (1 and 2) were synthesized and screened for activity as aldose reductase and L-hexonate dehydrogenase inhibitors. Compared to compounds 1, and 9,5'-compounds 2, synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b9793ebc751b203088e00c8ab4f9198
https://doi.org/10.1002/chin.199219177
https://doi.org/10.1002/chin.199219177
Autor:
Paul W Zinke, Raymond E. Conrow, and Anura P. Dantanarayana, Daniel Kuzmich, Steven J. Sproull, Mark T. DuPriest
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62b6785201f9eed8a638aa29e94a7caf
https://doi.org/10.1002/chin.199820200
https://doi.org/10.1002/chin.199820200
Autor:
Deason Michael E, Raymond E. Conrow, W. Dennis Dean, and Anura P. Dantanarayana, Paul W Zinke, Mark T. DuPriest, Steven J. Sproull
Publikováno v:
ChemInform. 30
A large scale synthesis of the topical carbonic anhydrase inhibitors AL-4623A (13a·HCl) and AL-4862 (13b) from 3-acetyl-2,5-dichlorothiophene (“DCAT”, 1) is described. Reaction of 1 with NaSBn gave thioether 2, which was converted via sulfenyl c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ea51f15ecf646d92f724c924bcba40f
https://doi.org/10.1002/chin.199929157
https://doi.org/10.1002/chin.199929157
Autor:
Billie M. York, D Barratt, Brenda W. Griffin, Young Han Park, R Barker, K Brazzell, Philip R. Mayer, Mark T. DuPriest
Publikováno v:
Xenobiotica. 22:543-550
1. Six potent aldose reductase inhibitors (ARI), three spirohydantoin (I to III) and three spirosuccinimide (IV to VI) compounds, showed similar IC50 activities in vitro for the inhibition of rat lens aldose reductase, but their ED50 values in diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58fd10b785805f37214d9e30aa8da4b
https://doi.org/10.3109/00498259209053117
https://doi.org/10.3109/00498259209053117
Publikováno v:
Journal of Medicinal Chemistry. 34:3229-3234
The first examples of spiro[fluorene-9,4'- and -9,5'-isothiazolidin]one dioxides (1 and 2) were synthesized and screened for activity as aldose reductase and L-hexonate dehydrogenase inhibitors. Compared to compounds 1, and 9,5'-compounds 2, synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68881c6c08fd3e2e23c02d2b2f99f96e
https://doi.org/10.1021/jm00115a011
https://doi.org/10.1021/jm00115a011
Publikováno v:
The Journal of Organic Chemistry. 51:2021-2023
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a61c1c5f5db0b0620a135406ddfe9ac1
https://doi.org/10.1021/jo00361a015
https://doi.org/10.1021/jo00361a015