Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mark T Waddingham"'
Autor:
Ryotaro Asano, Takeshi Ogo, Yoshiaki Morita, Akiyuki Kotoku, Tatsuo Aoki, Kyoko Hirakawa, Sayuri Nakayama, Jin Ueda, Akihiro Tsuji, Mark T Waddingham, Yasutoshi Ohta, Tetsuya Fukuda, Keiko Ohta-Ogo, Hatsue Ishibashi-Ueda, Teruo Noguchi, Satoshi Yasuda
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0260456 (2021)
BackgroundRight ventricular function is an important prognostic marker for pulmonary arterial hypertension. Native T1 mapping using cardiovascular magnetic resonance imaging can characterize the myocardium, but accumulating evidence indicates that T1
Externí odkaz:
https://doaj.org/article/e083a15fcfa94c28a6baf4821c4bf1cc
Autor:
James T Pearson, Mikiyasu Shirai, Vijayakumar Sukumaran, Cheng-Kun Du, Hirotsugu Tsuchimochi, Takashi Sonobe, Mark T Waddingham, Rajesh Katare, Daryl O Schwenke
Publikováno v:
Vascular Biology, Vol 1, Iss 1, Pp H97-H102 (2019)
Ghrelin is a small peptide with important roles in the regulation of appetite, gut motility, glucose homeostasis as well as cardiovascular protection. This review highlights the role that acyl ghrelin plays in maintaining normal endothelial function
Externí odkaz:
https://doaj.org/article/5a0dbb4f12df4203bf8e2a9d84c7af1a
Autor:
Mark T. Waddingham, Hirotsugu Tsuchimochi, Takashi Sonobe, Vasco Sequeira, Md Junayed Nayeem, Mikiyasu Shirai, James T. Pearson, Takeshi Ogo
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 8, Iss , Pp 100072- (2024)
Background: Pulmonary hypertension (PH) often leads to right ventricle (RV) failure, a significant cause of morbidity and mortality. Despite advancements in PH management, progression to RV maladaptation and subsequent failure remain a clinical chall
Externí odkaz:
https://doaj.org/article/c799fd064dab4b7da859a49b8d77c099
Autor:
Mark T. Waddingham, Vasco Sequeira, Diederik W. D. Kuster, Elisa Dal Canto, M. Louis Handoko, Frances S. deMan, Denielli daSilva Gonçalves Bós, Coen A. Ottenheijm, Shengyi Shen, Robbert J. van derPijl, Jolanda van derVelden, Walter J. Paulus, Etto C. Eringa
Publikováno v:
Physiological Reports, Vol 11, Iss 22, Pp n/a-n/a (2023)
Abstract Titin‐dependent stiffening of cardiomyocytes is a significant contributor to left ventricular (LV) diastolic dysfunction in heart failure with preserved LV ejection fraction (HFpEF). Small heat shock proteins (HSPs), such as HSPB5 and HSPB
Externí odkaz:
https://doaj.org/article/2586bb27a6ca48ef989b1e4ca6db635a
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 4, Iss , Pp 100036- (2023)
Hypertrophic cardiomyopathy (HCM) is a frequent inherited form of heart failure. The underlying cause of HCM is generally attributed to mutations in genes that encode for sarcomeric proteins, but the pathogenesis of the disease is also influenced by
Externí odkaz:
https://doaj.org/article/d22b4f365c34488b9d7765bb109279d5
Autor:
Hirotsugu Tsuchimochi, Takashi Sonobe, Keiji Umetani, Amanda J. Edgley, Mikiyasu Shirai, Dong Yun Zhan, Tadakatsu Inagaki, Jennifer P. Ngo, Yutaka Fujii, Hamish P Thambyah, James T. Pearson, Yi Ching Chen, Mark T. Waddingham, Cheng-Kun Du, Connie P. C. Ow, Darren J. Kelly, Vijayakumar Sukumaran
Publikováno v:
Clinical Science. 135:327-346
A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor block
Autor:
Michael M. Kreusser, Harald F. Langer, Paul Steendijk, Shahrooz Ghaderi, Vasco Sequeira, Niels Voigt, Gert-Hinrich Reil, Lars S. Maier, Mária Lódi, Zoltán Papp, Mark T. Waddingham, Dominik Linz, Mathias Hohl, Jan-Christian Reil, Dobromir Dobrev, Melissa Herwig, Andreas Mügge, Árpád Kovács, Nazha Hamdani, Svenja Meyhöfer
Publikováno v:
Journal of Physiology, 598(15), 3129-3153. WILEY
J Physiol
J Physiol
Key points The Anrep effect represents the alteration of left ventricular (LV) contractility to acutely enhanced afterload in a few seconds, thereby preserving stroke volume (SV) at constant preload. As a result of the missing preload stretch in our
Autor:
Mark T. Waddingham, Hirotsugu Tsuchimochi, Takashi Sonobe, Ryotaro Asano, Huiling Jin, Connie P. C. Ow, Daryl O. Schwenke, Rajesh Katare, Kohki Aoyama, Keiji Umetani, Masato Hoshino, Kentaro Uesugi, Mikiyasu Shirai, Takeshi Ogo, James T. Pearson
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Frontiers in Physiology
Frontiers in Physiology
The majority of the conventional techniques that are utilized for investigating the pathogenesis of cardiovascular disease in preclinical animal models do not permit microlevel assessment of in situ cardiomyocyte and microvascular functions. Therefor
Autor:
Irene Stafford, Sujith Chacko, B. Raman, Matthew Chapman, Giovanni Licari, John D. Horowitz, Michael P. Frenneaux, Sven Y. Surikow, Thanh H Nguyen, Doan T.M. Ngo, S. Chua, Yuan Zhang, Darren J. Kelly, Mark T. Waddingham, Alexander P. Bate, Kuljit Singh
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 213-226 (2018)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • Treatment of female rats with a single dose of isoproterenol results in apical hypokinesis mimicking Takotsubo syndrome • Myocardial inflammation includes increased content of 3-nitrotyrosine and poly(ADP-ribose)
Highlights • Treatment of female rats with a single dose of isoproterenol results in apical hypokinesis mimicking Takotsubo syndrome • Myocardial inflammation includes increased content of 3-nitrotyrosine and poly(ADP-ribose)
Autor:
Connie P. C. Ow, Huiling Jin, Jennifer P. Ngo, Takeshi Ogo, Hatsue-Ishibash Ueda, Hisashi Maeda, Vijayakumar Sukumaran, Hirotsugu Tsuchimochi, Mark T. Waddingham, James T. Pearson, Takashi Sonobe, Mikiyasu Shirai
Publikováno v:
Journal of Hypertension. 39:e251-e252