Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Mark T Butt"'
Autor:
Orion P Keifer, Juanmarco Gutierrez, Mark T Butt, Sarah D Cramer, Raymond Bartus, Malu Tansey, Daniel Deaver, Alexandre Betourne, Nicholas M Boulis
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0277718 (2023)
Riluzole is the only treatment known to improve survival in patients with Amyotrophic Lateral Sclerosis (ALS). However, oral riluzole efficacy is modest at best, further it is known to have large inter-individual variability of serum concentration an
Externí odkaz:
https://doaj.org/article/7df620d86c554759a272218b0a7868ed
Autor:
Richard Jay Smeyne, Charles B Breckenridge, Melissa Beck, Yun Jiao, Mark T Butt, Jeffrey C Wolf, Dan Zadory, Daniel J Minnema, Nicholas C Sturgess, Kim Z Travis, Andrew R Cook, Lewis L Smith, Philip A Botham
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164094 (2016)
The neurotoxicity of paraquat dichloride (PQ) was assessed in two inbred strains of 9- or 16-week old male C57BL/6 mice housed in two different laboratories and compared to the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PQ was ad
Externí odkaz:
https://doaj.org/article/f994ce1641f14c128b4b02f13f570ad2
Autor:
Jason Pinkstaff, Emma McCullagh, Anita Grover, Andrew C. Melton, Anu Cherukuri, Jill CM Wait, Annalisa Nguyen, Mark T. Butt, Jami L. Trombley, Randall P. Reed, Eric.L. Adams, Robert B. Boyd, Sundeep Chandra, Joshua Henshaw, Charles A. O’Neill, Eric Zanelli, Joseph Kovalchin
Publikováno v:
Toxicology Reports. 10:357-366
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::070b212bba201791cdf5674afb5b4732
https://doi.org/10.1016/j.toxrep.2023.02.014
https://doi.org/10.1016/j.toxrep.2023.02.014
Autor:
Orion P. Keifer, Juan Marco Gutierrez, Mark T. Butt, Sarah D. Cramer, Raymond Bartus, Malu Tansey, Daniel Deaver, Alexandre Betourne, Nicholas M Boulis
SummaryRiluzole is the only treatment known to improve survival in patients with Amyotrophic Lateral Sclerosis (ALS). However, oral riluzole efficacy is modest at best, further it is known to have large inter-individual variability of serum concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20d02187bf64e97949c9572636589104
https://doi.org/10.1101/2022.11.02.514962
https://doi.org/10.1101/2022.11.02.514962
Publikováno v:
Toxicology Letters. 344:34-45
ASP7962 is a small molecule inhibitor for the nerve growth factor (NGF) receptor, tropomyosin-related kinase A (TrkA). NGF contributes to the survival of sensory and sympathetic neurons through TrkA receptor activation. Gross, microscopic, and quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8d5b8c41b13e366568f16b7fcbc411
https://doi.org/10.1016/j.toxlet.2021.02.018
https://doi.org/10.1016/j.toxlet.2021.02.018
Autor:
Brad Bolon, Kevin D. Woolard, Lisa G. Lanigan, Bernard S Jortner, Duncan S. Russell, Virginia Godfrey, Ingrid D. Pardo, Mark T. Butt
Publikováno v:
Veterinary Pathology. 58:10-33
The peripheral nervous system (PNS) relays messages between the central nervous system (brain and spinal cord) and the body. Despite this critical role and widespread distribution, the PNS is often overlooked when investigating disease in diagnostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1298c44429c663eb3cb624022b08031
https://doi.org/10.1177/0300985820959231
https://doi.org/10.1177/0300985820959231
Autor:
Alys Bradley, Ramesh C. Kovi, Wolfgang Kaufmann, Deepa B. Rao, Mark T. Butt, Alok K. Sharma, Sibylle Gröters, Robert C. Sills, Robert H. Garman, Brad Bolon, Peter B Little, Sarah D Cramer, Makoto Shibutani, Catherine George, Stephanie Czasch, Georg Krinke, Isao Narama
Publikováno v:
Toxicologic Pathology. 48:827-844
Harmonization of diagnostic terminology used during the histopathologic analysis of rodent tissue sections from nonclinical toxicity studies will improve the consistency of data sets produced by laboratories located around the world. The INHAND Proje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9912069ec8635a5d7468dff80a3f91ef
https://doi.org/10.1177/0192623320951154
https://doi.org/10.1177/0192623320951154
Publikováno v:
Toxicologic Pathology. 48:238-243
Although necrosis and apoptosis are uncommon, autophagy of sensory neurons (ASN) in trigeminal and dorsal root ganglia is a very common, spontaneous finding in cynomolgus monkeys ( Macaca fascicularis). Data from one author’s (Butt) laboratory show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33baedc344d2fffe3df229f90bc308f2
https://doi.org/10.1177/0192623319857053
https://doi.org/10.1177/0192623319857053
Autor:
Georg Krinke, Brad Bolon, Bernard S Jortner, Deepa B. Rao, Karl F. Jensen, Robert H. Garman, Mark T. Butt, Lydia L. Andrews-Jones, Michael S. Thibodeau, Ingrid D. Pardo, James P. Morrison, Alok K. Sharma
Publikováno v:
Toxicologic Pathology. 46:372-402
Peripheral nervous system (PNS) toxicity is surveyed inconsistently in nonclinical general toxicity studies. These Society of Toxicologic Pathology “best practice” recommendations are designed to ensure consistent, efficient, and effective sampli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed0009f2a5dd7f9e9222878b8b9ff0a
https://doi.org/10.1177/0192623318772484
https://doi.org/10.1177/0192623318772484
Autor:
Patrice Belanger, Mark T. Butt, Thomas Cummings, Mark G. Evans, Mark Zorbas, Jessica-lyn Gremminger
Publikováno v:
Autonomic Neuroscience. 218:51-53
Tanezumab, a humanized monoclonal anti-NGF antibody, has demonstrated efficacy and safety profiles in Phase III clinical trials of chronic pain. In a 24-week study in non-human primates, morphological observations of sympathetic ganglia showed decrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115b995b519ae9ff3bfbcba3f6dd51eb
https://doi.org/10.1016/j.autneu.2019.02.004
https://doi.org/10.1016/j.autneu.2019.02.004