Zobrazeno 1 - 10
of 292
pro vyhledávání: '"Mark T, Hamann"'
Autor:
Dev Karan, Seema Dubey, Sumedha Gunewardena, Kenneth A. Iczkowski, Manohar Singh, Pengyuan Liu, Angelo Poletti, Yeun‐Mun Choo, Hui‐Zi Chen, Mark T. Hamann
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 1966-1979 (2024)
The androgen receptor (AR) is the main driver in the development of castration‐resistant prostate cancer, where the emergence of AR splice variants leads to treatment‐resistant disease. Through detailed molecular studies of the marine alkaloid ma
Externí odkaz:
https://doaj.org/article/8a6bd94c9bdf47e0a2052c8d7ddc3d56
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract In 1957 Abbott and Ballantine described a highly toxic activity from a dinoflagellate isolated from the English Channel in 1949 by Mary Park. From a culture maintained at Plymouth Laboratory since 1950, we have been able to isolate two toxic
Externí odkaz:
https://doaj.org/article/14fe5bcbe51a4059a339375fbe45309c
Autor:
Menny M. Benjamin, George S. Hanna, Cody F. Dickinson, Yeun-Mun Choo, Xiaojuan Wang, Jessica A. Downs-Bowen, Ramyani De, Tamara R. McBrayer, Raymond F. Schinazi, Sarah E. Nielson, Joan M. Hevel, Pankaj Pandey, Robert J. Doerksen, Danyelle M. Townsend, Jie Zhang, Zhiwei Ye, Scott Wyer, Lucas Bialousow, Mark T. Hamann
Publikováno v:
Molecules, Vol 29, Iss 21, p 5081 (2024)
The design and synthesis of antiviral compounds were guided by computationally predicted data against highly conserved non-structural proteins (Nsps) of the SARS-CoV-2 coronavirus. Chromenephenylmethanone-1 (CPM-1), a novel biphenylpyran (BPP), was s
Externí odkaz:
https://doaj.org/article/9f48bea30a7a4d548c45cff1360d4a7f
Autor:
Zhiwei Bian, Menny M. Benjamin, Lucas Bialousow, Yintai Tian, G. Aaron Hobbs, Dev Karan, Yeun-Mun Choo, Mark T. Hamann, Xiaojuan Wang
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e33204- (2024)
Sine oculis homeoprotein 1 (SIX1), a prominent representative of the homeodomain transcription factors within the SIX family, has attracted significant interest owing to its role in tumorigenesis, cancer progression, and prognostic assessments. Initi
Externí odkaz:
https://doaj.org/article/a201e0c4d5c54445b4f037ceae53416a
Autor:
Bradley A. Krisanits, Pamela Woods, Lourdes M. Nogueira, Demarcus D. Woolfork, Courtney E. Lloyd, Andrew Baldwin, Callan C. Frye, Kendell D. Peterson, Sean D. Cosh, Qi-Jin Guo, Laura S. Spruill, Michael B. Lilly, Kristi Helke, Hong Li, George S. Hanna, Mark T. Hamann, Courtney Thomas, Mahtabuddin Ahmed, Monika B. Gooz, Victoria J. Findlay, David P. Turner
Publikováno v:
Translational Oncology, Vol 17, Iss , Pp 101350- (2022)
The molecular implications of food consumption on cancer etiology are poorly defined. The rate of nutrition associated non-enzymatic glycoxidation, a reaction that occurs between reactive carbonyl groups on linear sugars and nucleophilic amino, lysyl
Externí odkaz:
https://doaj.org/article/cec52ade50dc4295875eee77c2f2d05b
Publikováno v:
Marine Drugs, Vol 20, Iss 11, p 678 (2022)
This Special Issue is dedicated to the memory of Professor Paul J [...]
Externí odkaz:
https://doaj.org/article/aa13c8f96fcb4afd8204b44bb1eebd48
Autor:
Vedanjali Gogineni, Joonseok Oh, Amanda L. Waters, Michelle Kelly, Robert Stone, Mark T. Hamann
Publikováno v:
Frontiers in Marine Science, Vol 7 (2020)
Marine sources have long been known for their potential to produce unique skeletons and various biological activities. Fractionation of the ethanol extracts of an undescribed species of MonanchoraCarter, 1883 and a specimen closely comparable to Mona
Externí odkaz:
https://doaj.org/article/0e3da6e07d784cc8ae9d912b07f2c3a2
Autor:
Alejandro M. S. Mayer, Mary L. Hall, Joseph Lach, Jonathan Clifford, Kevin Chandrasena, Caitlin Canton, Maria Kontoyianni, Yeun-Mun Choo, Dev Karan, Mark T. Hamann
Publikováno v:
Marine Drugs, Vol 19, Iss 9, p 506 (2021)
Manzamines are complex polycyclic marine-derived β-carboline alkaloids with reported anticancer, immunostimulatory, anti-inflammatory, antibacterial, antiviral, antimalarial, neuritogenic, hyperlipidemia, and atherosclerosis suppression bioactivitie
Externí odkaz:
https://doaj.org/article/b3bab1dd54084d17be970cacbdcf5f09
Autor:
Devadoss J. Samuvel, Nga T. Nguyen, Hartmut Jaeschke, John J. Lemasters, Xiaojuan Wang, Yeun-Mun Choo, Mark T. Hamann, Zhi Zhong
Publikováno v:
J Nat Prod
Oxidative stress plays an important role in acetaminophen (APAP) -induced hepatotoxicity. Platanosides (PTSs) isolated from the American sycamore tree (Platanus occidentalis) represent a potential new 4-molecule botanical-drug class of antibiotics ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1023811407229365813947c9df7a750
https://doi.org/10.1021/acs.jnatprod.2c00324
https://doi.org/10.1021/acs.jnatprod.2c00324
Autor:
Zachary Boswell, Jacopo Umberto Verga, James Mackle, Karen Guerrero-Vazquez, Olivier P Thomas, James Cray, Bethany J Wolf, Yeun-Mun Choo, Peter Croot, Mark T Hamann, Gary Hardiman
Publikováno v:
Boswell, Z, Verga, J U, Mackle, J, Guerrero-Vazquez, K, Thomas, O P, Cray, J, Wolf, B J, Choo, Y-M, Croot, P, Hamann, M T & Hardiman, G 2023, ' In-silico approaches for the screening and discovery of broad-spectrum marine natural product antiviral agents against coronaviruses ', Infection and Drug Resistance, vol. 16, pp. 2321-2338 . https://doi.org/10.2147/IDR.S395203
The urgent need for SARS-CoV-2 controls has led to a reassessment of approaches to identify and develop natural product inhibitors of zoonotic, highly virulent, and rapidly emerging viruses. There are yet no clinically approved broad-spectrum antivir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c564a6b2d0f1593d597d479b062178f4
https://pure.qub.ac.uk/en/publications/dbb85dc9-75db-42db-bc6c-7f68f8e83072
https://pure.qub.ac.uk/en/publications/dbb85dc9-75db-42db-bc6c-7f68f8e83072
