Zobrazeno 1 - 10
of 578
pro vyhledávání: '"Mark T, Drayson"'
Autor:
Fendi Pradana, Tarondeep Nijjar, Phoebe A. Cox, Paul T. Morgan, Tim Podlogar, Samuel J. E. Lucas, Mark T. Drayson, Francesca A. M. Kinsella, Alex J. Wadley
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
IntroductionPeripheral blood stem cell (PBSC) donation is the primary procedure used to collect hematopoietic stem and progenitor cells (HSPCs) for hematopoietic stem cell transplantation. Single bouts of exercise transiently enrich peripheral blood
Externí odkaz:
https://doaj.org/article/e816c4585b1a4d5697a22e142d5557cc
Autor:
Adrian M. Shields, Sian E. Faustini, Siobhan Young, Sarah Terjesen, Nicholas I. McCarthy, Rachel L. Anderson, Mark T. Drayson, Alex G. Richter
Publikováno v:
eJHaem, Vol 4, Iss 2, Pp 339-349 (2023)
Abstract Secondary immunodeficiency (SID), manifesting as increased susceptibility to infection, is an emergent clinical problem in haematoncology. Management of SID includes vaccination, prophylactic antibiotics (pAbx) and immunoglobulin replacement
Externí odkaz:
https://doaj.org/article/ce8f1af0fdd245048ca093557910b485
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 32, Iss , Pp 100661- (2023)
Health behaviours such as being physically active and having good quality sleep have been associated with decreased susceptibility to infection and stronger antibody responses to vaccination. Less is known about how such factors might influence the m
Externí odkaz:
https://doaj.org/article/485a36b7d8e4419abb9dd708e918331a
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 10, Pp 1-6 (2022)
Abstract Despite enormous global investment, translational medical research faces considerable challenges and patients, and their doctors are frequently frustrated by the apparent lack of research activity or progress. Understanding the factors that
Externí odkaz:
https://doaj.org/article/066b500f70c648a681d9d49101146623
Autor:
John R. Jones, David A. Cairns, Tom Menzies, Charlotte Pawlyn, Faith E. Davies, Rachel Sigsworth, Annamaria Brioli, Matthew W. Jenner, Martin F. Kaiser, Catherine Olivier, Molly Reed, Mark T. Drayson, Roger G. Owen, Kevin D. Boyd, Gordon Cook, Gareth J. Morgan, Graham H. Jackson
Publikováno v:
EClinicalMedicine, Vol 62, Iss , Pp 102099- (2023)
Summary: Background: Early trials of long-term lenalidomide use reported an increased incidence of second primary malignancy (SPM), including acute myeloid leukaemia and myelodysplastic syndrome. Later, meta-analysis suggested the link to be secondar
Externí odkaz:
https://doaj.org/article/7b401565bf86409c8aca965e1f509a9d
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionB cells, which have long been thought to be minor players in the development of anti-tumor responses, have been implicated as key players in lung cancer pathogenesis and response to checkpoint blockade in patients with lung cancer. Enrich
Externí odkaz:
https://doaj.org/article/aace951dd8ed4f99849368e6815456c9
Autor:
Akshay J. Patel, Zena N. Willsmore, Naeem Khan, Alex Richter, Babu Naidu, Mark T. Drayson, Sophie Papa, Andrew Cope, Sophia N. Karagiannis, Esperanza Perucha, Gary W. Middleton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Immune checkpoint blockade is a promising approach to treat lung cancer, however, immune related adverse events hold back success in some patients. Here authors show that regulatory B cells fail to limit self-reactive T cells in these patients, and B
Externí odkaz:
https://doaj.org/article/c2085253ca8c457fb16c85cb9930af88
Autor:
Rachel E. Lamerton, Edith Marcial-Juarez, Sian E. Faustini, Marisol Perez-Toledo, Margaret Goodall, Siân E. Jossi, Maddy L. Newby, Iain Chapple, Thomas Dietrich, Tonny Veenith, Adrian M. Shields, Lorraine Harper, Ian R. Henderson, Julie Rayes, David C. Wraith, Steve P. Watson, Max Crispin, Mark T. Drayson, Alex G. Richter, Adam F. Cunningham
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Antibodies specific for the spike glycoprotein (S) and nucleocapsid (N) SARS-CoV-2 proteins are typically present during severe COVID-19, and induced to S after vaccination. The binding of viral antigens by antibody can initiate the classical complem
Externí odkaz:
https://doaj.org/article/e96e183f4c0140d195866a01fcba3220
Autor:
Adrian M. Shields, Sian E. Faustini, Harriet J. Hill, Saly Al-Taei, Chloe Tanner, Fiona Ashford, Sarita Workman, Fernando Moreira, Nisha Verma, Hollie Wagg, Gail Heritage, Naomi Campton, Zania Stamataki, Mark T. Drayson, Paul Klenerman, James E. D. Thaventhiran, Shuayb Elkhalifa, Sarah Goddard, Sarah Johnston, Aarnoud Huissoon, Claire Bethune, Suzanne Elcombe, David M. Lowe, Smita Y. Patel, Sinisa Savic, Alex G. Richter, Siobhan O. Burns, the COV-AD consortium, Zahra Ahmed, Angus Best, Joanne Dasgin, Mohammad Dinally, Elena Efstathiou, Theresa McCarthy, Madeeha Hoque, Shannon Page, Timothy Plant, Zehra Suleiman, Neil Townsend, Charlotte Trinham, Sinead Walder, Hollie Bancroft, Michelle Bates, Hayley Clifford, Christopher McGee, Samuel Chee, Lucy Common, Archana Herwadkar, Karen Knowles, Maria Poulaka, Georgina Davis, Daniel Mullan, Stuart Wareham, Fatima Dhalla, Rashmi Jain, Hadeil Morsi, Nicholas Peters, Mark Gompels, Malgorzata Slowinsksa, Dan Hartland, Emily Heritage, Joe Humphreys, Deborah Hughes, Ann Ivory, Sinead Kelly, Eileen O’Grady, Archana Shajidevadas
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundPatients with primary and secondary antibody deficiency are vulnerable to COVID-19 and demonstrate diminished responses following two-dose SARS-CoV-2 vaccine schedules. Third primary vaccinations have been deployed to enhance their humoral
Externí odkaz:
https://doaj.org/article/734129a987774428ad5c1764ee4dea11
Autor:
Gabriella L. Morley, Stephen Taylor, Sian Jossi, Marisol Perez-Toledo, Sian E. Faustini, Edith Marcial-Juarez, Adrian M. Shields, Margaret Goodall, Joel D. Allen, Yasunori Watanabe, Maddy L. Newby, Max Crispin, Mark T. Drayson, Adam F. Cunningham, Alex G. Richter, Matthew K. O’Shea
Publikováno v:
Emerging Infectious Diseases, Vol 26, Iss 12, Pp 2970-2973 (2020)
Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sa
Externí odkaz:
https://doaj.org/article/365684546bd3483a88bc7cf4c95209a9