Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mark Stump"'
Autor:
Saskia M. Brachmann, Michael N. Hall, Francesco Hofmann, William R. Sellers, Sauveur-Michel Maira, Keith Calkins, Mitko Ristov, Daniel Guthy, Mark Stump, David Ruddy, Eric Billy, Malika Kazic-Legueux, Grégory Marszalek, Hélène Erasimus, Janina Juengert, Hans Voshol, Thomas Ferrat, Christian Schnell, Sandra Mollé, Audrey Kauffmann, Barbara Herkert
Despite major dependence of PTENLOF/BRAFMUT melanoma cell lines on PI3Kβ, PI3Kαi synergizes with PI3Kβi to inhibit downstream signaling upon long-term treatment. A) +B) Effects of treatment with the indicated inhibitors as single-agents or in comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93575cb74b408c503761ce44d54ca36a
https://doi.org/10.1158/0008-5472.22408859
https://doi.org/10.1158/0008-5472.22408859
Autor:
Saskia M. Brachmann, Michael N. Hall, Francesco Hofmann, William R. Sellers, Sauveur-Michel Maira, Keith Calkins, Mitko Ristov, Daniel Guthy, Mark Stump, David Ruddy, Eric Billy, Malika Kazic-Legueux, Grégory Marszalek, Hélène Erasimus, Janina Juengert, Hans Voshol, Thomas Ferrat, Christian Schnell, Sandra Mollé, Audrey Kauffmann, Barbara Herkert
Supplementary materials and methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9627dbf5e423dd32eb28cc0069ef3a39
https://doi.org/10.1158/0008-5472.22408832
https://doi.org/10.1158/0008-5472.22408832
Autor:
Saskia M. Brachmann, Michael N. Hall, Francesco Hofmann, William R. Sellers, Sauveur-Michel Maira, Keith Calkins, Mitko Ristov, Daniel Guthy, Mark Stump, David Ruddy, Eric Billy, Malika Kazic-Legueux, Grégory Marszalek, Hélène Erasimus, Janina Juengert, Hans Voshol, Thomas Ferrat, Christian Schnell, Sandra Mollé, Audrey Kauffmann, Barbara Herkert
MAPK pathway inhibition synergizes with PI3Kβ inhibition in WM-266-4, but not in A-375. A-D) Determination of PI3K/BRAF and PI3K/MEK inhibitor synergy in WM-266-4 (A+B) and A-375 (C+D) using proliferation assays. Dose matrices highlight percentages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e9bcd202f1b0a4949edea0fc784bc5
https://doi.org/10.1158/0008-5472.22408853.v1
https://doi.org/10.1158/0008-5472.22408853.v1
Autor:
Saskia M. Brachmann, Michael N. Hall, Francesco Hofmann, William R. Sellers, Sauveur-Michel Maira, Keith Calkins, Mitko Ristov, Daniel Guthy, Mark Stump, David Ruddy, Eric Billy, Malika Kazic-Legueux, Grégory Marszalek, Hélène Erasimus, Janina Juengert, Hans Voshol, Thomas Ferrat, Christian Schnell, Sandra Mollé, Audrey Kauffmann, Barbara Herkert
PI3K pathway inhibition using PI3Kβi/PI3Kαi or PI3Kβi/IGF1Ri enhances the anti-proliferative effect of the BRAF/MEK inhibition regimen in PTENLOF/BRAFMUT cell lines and shifts the response towards cell death A+B) Validation of BRAFi/MEKi activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0727fb7bfd7bf7ece51eed72c02810e7
https://doi.org/10.1158/0008-5472.22408844.v1
https://doi.org/10.1158/0008-5472.22408844.v1
Autor:
Saskia M. Brachmann, Michael N. Hall, Francesco Hofmann, William R. Sellers, Sauveur-Michel Maira, Keith Calkins, Mitko Ristov, Daniel Guthy, Mark Stump, David Ruddy, Eric Billy, Malika Kazic-Legueux, Grégory Marszalek, Hélène Erasimus, Janina Juengert, Hans Voshol, Thomas Ferrat, Christian Schnell, Sandra Mollé, Audrey Kauffmann, Barbara Herkert
IGF1R inhibition synergizes with PI3Kβ inhibition in WM-266-4, but not in A-375. A) Synergistic proliferation inhibition upon PI3K/IGF1R inhibitor combination in WM-266-4 cells. WM-266-4 cells were treated with increasing concentrations of PI3Ki and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb49f3d3cbc67b15ee73a532c5fc41e
https://doi.org/10.1158/0008-5472.22408856.v1
https://doi.org/10.1158/0008-5472.22408856.v1
Autor:
Saskia M. Brachmann, Michael N. Hall, Francesco Hofmann, William R. Sellers, Sauveur-Michel Maira, Keith Calkins, Mitko Ristov, Daniel Guthy, Mark Stump, David Ruddy, Eric Billy, Malika Kazic-Legueux, Grégory Marszalek, Hélène Erasimus, Janina Juengert, Hans Voshol, Thomas Ferrat, Christian Schnell, Sandra Mollé, Audrey Kauffmann, Barbara Herkert
Concomitant inhibition of PI3Kβ, IGF1R and MAPK signaling are leading to full long-term pathway blockade. A) +B) Effects of treatment with the indicated inhibitors as single-agents or in combination on WM-266-4 (A) or RVH-421 (B) were evaluated by i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff15d47b2d933e828efa544cb89b427
https://doi.org/10.1158/0008-5472.22408850
https://doi.org/10.1158/0008-5472.22408850
Autor:
Saskia M. Brachmann, Michael N. Hall, Francesco Hofmann, William R. Sellers, Sauveur-Michel Maira, Keith Calkins, Mitko Ristov, Daniel Guthy, Mark Stump, David Ruddy, Eric Billy, Malika Kazic-Legueux, Grégory Marszalek, Hélène Erasimus, Janina Juengert, Hans Voshol, Thomas Ferrat, Christian Schnell, Sandra Mollé, Audrey Kauffmann, Barbara Herkert
PI3Kβi (rac-KIN-193) treatment induces the interaction of p85 with a panel of proteins in PTENLOF/BRAFMUT melanoma. RVH-421 were treated with DMSO or 1μM PI3Kβi for 2h. Lysates were subjected to immunoprecipitation using an antibody targeting p85.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6573905a3003128600aa390204fc0128
https://doi.org/10.1158/0008-5472.22408826.v1
https://doi.org/10.1158/0008-5472.22408826.v1
Autor:
Saskia M. Brachmann, Michael N. Hall, Francesco Hofmann, William R. Sellers, Sauveur-Michel Maira, Keith Calkins, Mitko Ristov, Daniel Guthy, Mark Stump, David Ruddy, Eric Billy, Malika Kazic-Legueux, Grégory Marszalek, Hélène Erasimus, Janina Juengert, Hans Voshol, Thomas Ferrat, Christian Schnell, Sandra Mollé, Audrey Kauffmann, Barbara Herkert
The introduction of MAPK pathway inhibitors paved the road for significant advancements in the treatment of BRAF-mutant (BRAFMUT) melanoma. However, even BRAF/MEK inhibitor combination therapy has failed to offer a curative treatment option, most lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa2437e11bf4032198c762b061c55fa
https://doi.org/10.1158/0008-5472.c.6507632
https://doi.org/10.1158/0008-5472.c.6507632
Autor:
Saskia M. Brachmann, Michael N. Hall, Francesco Hofmann, William R. Sellers, Sauveur-Michel Maira, Keith Calkins, Mitko Ristov, Daniel Guthy, Mark Stump, David Ruddy, Eric Billy, Malika Kazic-Legueux, Grégory Marszalek, Hélène Erasimus, Janina Juengert, Hans Voshol, Thomas Ferrat, Christian Schnell, Sandra Mollé, Audrey Kauffmann, Barbara Herkert
PI3Kβ inhibition induces p85/IRS2 interaction in a time-dependent manner in the PTENLOF/BRAFMUT melanoma cell line RVH-421 that is mediated by negative feedback signaling. A) Co-immunoprecipitation experiments were carried out using cell lysates of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56edb9efed27f27b8729f5eb1bd76c4f
https://doi.org/10.1158/0008-5472.22408862
https://doi.org/10.1158/0008-5472.22408862
Autor:
Saskia M. Brachmann, Michael N. Hall, Francesco Hofmann, William R. Sellers, Sauveur-Michel Maira, Keith Calkins, Mitko Ristov, Daniel Guthy, Mark Stump, David Ruddy, Eric Billy, Malika Kazic-Legueux, Grégory Marszalek, Hélène Erasimus, Janina Juengert, Hans Voshol, Thomas Ferrat, Christian Schnell, Sandra Mollé, Audrey Kauffmann, Barbara Herkert
Supplementary information on the selectivity analysis shown in Figure 1A. (A) Representation of classes for all compounds used for the selectivity analysis. (B) Information on all significant hits showing selectivity for PTENLOF cell lines. The table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5402b9d8254c970563bb6dd2fa00ff29
https://doi.org/10.1158/0008-5472.22408829.v1
https://doi.org/10.1158/0008-5472.22408829.v1