Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mark Stidham"'
Autor:
Mark Stidham, Daniel R. Reyes, Vickie Brown-Driver, G C Kedar, Robert Haselbeck, John T. Finn, Karen Joy Shaw, Mark Hilgers
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:2009-2013
Targeted antisense and gene replacement mutagenesis experiments demonstrate that only the murA1 gene and not the murA2 gene is required for the normal cellular growth of Bacillus anthracis . Antisense-based modulation of murA1 gene expression hyperse
Autor:
G C Kedar, Daniel R. Reyes, Mark Stidham, Vickie Brown-Driver, Mark Hilgers, Karen Joy Shaw, Robert Haselbeck, John T. Finn
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:1708-1718
The biowarfare-relevant bacterial pathogen Bacillus anthracis contains two paralogs each of the metS and murB genes, which encode the important antibiotic target functions methionyl-tRNA synthetase and UDP- N -acetylenolpyruvoylglucosamine reductase,
Autor:
Mark Stidham, Thanh Lam, Bryan P. Kwan, Mark L. Cunningham, Zhiyong Chen, Felice C. Lightstone, Junhu Zhang, Karen J. Shaw, Leslie W. Tari, Toan B. Nguyen, Christopher J. Creighton, John T. Finn, Xiaoming Li, Michael Trzoss, Daniel C. Bensen, Sergio E. Wong, Jay C. Nix
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(5)
The bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) are essential enzymes that control the topological state of DNA during replication. The high degree of conservation in the ATP-binding pockets of these enzymes make them appea
Autor:
Vickie Brown-Driver, Christopher J. Creighton, John T. Finn, Toan B. Nguyen, Mark L. Cunningham, Zhiyong Chen, Amanda Castellano, Mark Stidham, Sergio E. Wong, Xiaoming Li, Karen J. Shaw, Thanh Lam, Junhu Zhang, Bryan P. Kwan, Kirk J. Nelson, Felice C. Lightstone, Leslie W. Tari, Daniel C. Bensen, Micheal Trzoss
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(5)
The structurally related bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) have long been recognized as prime candidates for the development of broad spectrum antibacterial agents. However, GyrB/ParE targeting antibacterials with
Autor:
Xiaoming Li, Mark Hilgers, Mark Cunningham, Zhiyong Chen, Michael Trzoss, Junhu Zhang, Lucy Kohnen, Thanh Lam, Chris Creighton, Kedar GC, Kirk Nelson, Bryan Kwan, Mark Stidham, Vickie Brown-Driver, Karen J. Shaw, John Finn
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
Dihydrofolate reductase (DHFR) inhibitors such as trimethoprim (TMP) have long played a significant role in the treatment of bacterial infections. Not surprisingly, after decades of use there is now bacterial resistance to TMP and therefore a need to
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(14)
Multiple inhibitors of the antibacterial target, Staphylococcus aureus MetRS, were identified by virtual screening. The process consisted of building a Catalyst® pharmacophore from a ligand-S. aureus MetRS structure and using this pharmacophore to s