Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Mark Southwood"'
Autor:
Mark Southwood, Tomasz Krenz, Natasha Cant, Manisha Maurya, Jana Gazdova, Perry Maxwell, Claire McGready, Ellen Moseley, Susan Hughes, Peter Stewart, Manuel Salto‐Tellez, Daniel Groelz, Doris Rassl, On behalf of the STRATfix Consortium
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 6, Iss 1, Pp 40-54 (2020)
Abstract Whilst adequate for most existing pathological tests, formalin is generally considered a poor DNA preservative and use of alternative fixatives may prove advantageous for molecular testing of tumour material; an increasingly common approach
Externí odkaz:
https://doaj.org/article/a9d620a0402d45b48de3ed93c2c95d54
Autor:
Nadine D. Arnold, Josephine A. Pickworth, Laura E. West, Sarah Dawson, Joana A. Carvalho, Helen Casbolt, Adam T. Braithwaite, James Iremonger, Lewis Renshall, Volker Germaschewski, Matthew McCourt, Philip Bland-Ward, Hager Kowash, Abdul G. Hameed, Alexander M. K. Rothman, Maria G. Frid, A. A. Roger Thompson, Holly R. Evans, Mark Southwood, Nicholas W. Morrell, David C. Crossman, Moira K. B. Whyte, Kurt R. Stenmark, Christopher M. Newman, David G. Kiely, Sheila E. Francis, Allan Lawrie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Pulmonary arterial hypertension (PAH) is characterised by progressive pulmonary vascular remodelling. Here, Arnold et al. develop a therapeutic antibody targeting osteoprotegerin and find it attenuates pulmonary vascular remodelling in multiple roden
Externí odkaz:
https://doaj.org/article/fbbe9cf6fb44471db21ebf04ce2094b6
Autor:
Lu Long, Xudong Yang, Mark Southwood, Stephen Moore, Alexi Crosby, Paul D. Upton, Benjamin J. Dunmore, Nicholas W. Morrell
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Pulmonary arterial hypertension is a fatal disorder of the lung circulation in which accumulation of vascular cells progressively obliterates the pulmonary arterioles. This results in sustained elevation in pulmonary artery pressure leading eventuall
Externí odkaz:
https://doaj.org/article/2cf38ab99f424af698165ce9146c4393
Autor:
Stefan Gräf, Matthias Haimel, Marta Bleda, Charaka Hadinnapola, Laura Southgate, Wei Li, Joshua Hodgson, Bin Liu, Richard M. Salmon, Mark Southwood, Rajiv D. Machado, Jennifer M. Martin, Carmen M. Treacy, Katherine Yates, Louise C. Daugherty, Olga Shamardina, Deborah Whitehorn, Simon Holden, Micheala Aldred, Harm J. Bogaard, Colin Church, Gerry Coghlan, Robin Condliffe, Paul A. Corris, Cesare Danesino, Mélanie Eyries, Henning Gall, Stefano Ghio, Hossein-Ardeschir Ghofrani, J. Simon R. Gibbs, Barbara Girerd, Arjan C. Houweling, Luke Howard, Marc Humbert, David G. Kiely, Gabor Kovacs, Robert V. MacKenzie Ross, Shahin Moledina, David Montani, Michael Newnham, Andrea Olschewski, Horst Olschewski, Andrew J. Peacock, Joanna Pepke-Zaba, Inga Prokopenko, Christopher J. Rhodes, Laura Scelsi, Werner Seeger, Florent Soubrier, Dan F. Stein, Jay Suntharalingam, Emilia M. Swietlik, Mark R. Toshner, David A. van Heel, Anton Vonk Noordegraaf, Quinten Waisfisz, John Wharton, Stephen J. Wort, Willem H. Ouwehand, Nicole Soranzo, Allan Lawrie, Paul D. Upton, Martin R. Wilkins, Richard C. Trembath, Nicholas W. Morrell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Pulmonary arterial hypertension (PAH) is a rare lung disorder characterised by narrowing and obliteration of small pulmonary arteries ultimately leading to right heart failure. Here, the authors sequence whole genomes of over 1000 PAH patients and id
Externí odkaz:
https://doaj.org/article/cb3171b4e79940aa9ab812b5a9ce621a
Autor:
Liam A. Hurst, Benjamin J. Dunmore, Lu Long, Alexi Crosby, Rafia Al-Lamki, John Deighton, Mark Southwood, Xudong Yang, Marko Z. Nikolic, Blanca Herrera, Gareth J. Inman, John R. Bradley, Amer A. Rana, Paul D. Upton, Nicholas W. Morrell
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Reduced BMP receptor II signalling underlies pulmonary arterial hypertension (PAH). Here, Hurstet al. show that TNFα subverts BMP signalling by increasing BMP6 expression and signalling via an alternative BMP receptor, ALK2, in pulmonary artery smoo
Externí odkaz:
https://doaj.org/article/17874564742043b0848f710d036fb95a
Autor:
Mark Toshner, Benjamin J Dunmore, Eoin F McKinney, Mark Southwood, Paola Caruso, Paul D Upton, John P Waters, Mark L Ormiston, Jeremy N Skepper, Gerard Nash, Amer A Rana, Nicholas W Morrell
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91334 (2014)
The endothelial cell has a remarkable ability for sub-specialisation, adapted to the needs of a variety of vascular beds. The role of developmental programming versus the tissue contextual environment for this specialization is not well understood. H
Externí odkaz:
https://doaj.org/article/a65b5f6b922b480a9cbe22102ede147c
Autor:
Charaka M. Hadinnapola, Mark Southwood, Jules Hernández – Sánchez, Katherine Bunclark, Michael Newnham, Emilia M. Swietlik, John Cannon, Stephen D. Preston, Karen Sheares, Dolores Taboada, Nicholas Screaton, David P. Jenkins, Nicholas W. Morrell, Mark Toshner, Joanna Pepke-Zaba
INTRODUCTION: Chronic thromboembolic pulmonary hypertension (CTEPH) is an underdiagnosed disease of uncertain etiology. Altered endothelial homeostasis, defective angiogenesis and inflammation are implicated. Angiopoietin 2 (Ang2) impairs acute throm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d444e0ebaf5070faa555ac5414852c
https://www.repository.cam.ac.uk/handle/1810/344392
https://www.repository.cam.ac.uk/handle/1810/344392
Autor:
Mark Southwood, Tomasz Krenz, Natasha Cant, Manisha Maurya, Jana Gazdova, Perry Maxwell, Claire McGready, Ellen Moseley, Susan Hughes, Peter Stewart, Manuel Salto‐Tellez, Daniel Groelz, Doris Rassl, On behalf of the STRATfix Consortium
Publikováno v:
The Journal of Pathology: Clinical Research
Southwood, M, Krenz, T, Cant, N, Maurya, M, Gazdova, J, Maxwell, P, McGready, C, Moseley, E, Hughes, S, Stewart, P, Salto-Tellez, M, Groelz, D & Rassl, D 2020, ' Systematic evaluation of PAXgene® tissue fixation for the histopathological and molecular study of lung cancer ', The Journal of Pathology: Clinical Research, vol. 6, no. 1, pp. 40-54 . https://doi.org/10.1002/cjp2.145, https://doi.org/10.1002/cjp2.145
The Journal of Pathology: Clinical Research, Vol 6, Iss 1, Pp 40-54 (2020)
Southwood, M, Krenz, T, Cant, N, Maurya, M, Gazdova, J, Maxwell, P, McGready, C, Moseley, E, Hughes, S, Stewart, P, Salto-Tellez, M, Groelz, D & Rassl, D 2020, ' Systematic evaluation of PAXgene® tissue fixation for the histopathological and molecular study of lung cancer ', The Journal of Pathology: Clinical Research, vol. 6, no. 1, pp. 40-54 . https://doi.org/10.1002/cjp2.145, https://doi.org/10.1002/cjp2.145
The Journal of Pathology: Clinical Research, Vol 6, Iss 1, Pp 40-54 (2020)
Whilst adequate for most existing pathological tests, formalin is generally considered a poor DNA preservative and use of alternative fixatives may prove advantageous for molecular testing of tumour material; an increasingly common approach to identi
Autor:
Peter Carmeliet, Robert Lafyatis, Mark Southwood, João P Monteiro, Katherine M Ross Stewart, Andrew H. Baker, Ana-Mishel Spiroski, Mairi Brittan, Jessica P. Scanlon, Neil C. Henderson, Paul D. Upton, Kevin Stewart, Shiau Haln Chen, Patrick W. F. Hadoke, Sweta Sweta, Ziwen Li, Alena Shmakova, Adam Handen, Stephen D Moore, Julie Rodor, Stephen Y. Chan, Axelle Caudrillier, Ross Dobie, Laura P.M.H. de Rooij, Beth Ep Henderson, Nicholas W. Morrell
Publikováno v:
Rodor, J, Chen, S H, Scanlon, J P, Monteiro, J P, Caudrillier, A, Sweta, S, Ross Stewart, K, Shmakova, A, Dobie, R, Henderson, B EP, Stewart, K, Hadoke, P W F, Southwood, M, Moore, S D, Upton, P D, Morrell, N W, Li, Z, Chan, S Y, Handen, A, Lafyatis, R, de Rooij, L P M H, Henderson, N C, Carmeliet, P, Spiroski, A-M, Brittan, M & Baker, A H 2021, ' Single-cell RNA-seq profiling of mouse endothelial cells in response to pulmonary arterial hypertension ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvab296
AimsEndothelial cell (EC) dysfunction drives the initiation and pathogenesis of pulmonary arterial hypertension (PAH). We aimed to characterize EC dynamics in PAH at single-cell resolution.Methods and resultsWe carried out single-cell RNA sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891a9d5ea79aa7f348c696c61724c06b
https://www.pure.ed.ac.uk/ws/files/227519929/cvab296.pdf
https://www.pure.ed.ac.uk/ws/files/227519929/cvab296.pdf
Autor:
Robert C. Glen, Anthony P. Davenport, Duuamene Nyimanu, Alexi Crosby, Janet J. Maguire, Guido Buonincontri, Cai Read, Mark Southwood, Thomas L Williams, Nicholas W. Morrell, Peiran Yang, Rhoda E. Kuc, Stephen J. Sawiak
Publikováno v:
British Journal of Pharmacology
© 2019 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. Background and Purpose: Apelin is an endogenous vasodilatory and inotropic peptide that is down-regulated in human p