Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mark Solc"'
Autor:
Philip N. Vrkljan, Kenneth E. Neet, Mark Solc, Gail Lawrance, Igor L. Shamovsky, Richard J. Riopelle, Joan I. Post, Suzanne M. Dostaler, Gregory M. Ross, Sang B. Woo
Publikováno v:
Journal of Neurochemistry. 78:515-523
It has recently been shown that transition metal cations Zn2+ and Cu2+ bind to histidine residues of nerve growth factor (NGF) and other neurotrophins (a family of proteins important for neuronal survival) leading to their inactivation. Experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::905db55da3d8786bea8b760b41c6c894
https://doi.org/10.1046/j.1471-4159.2001.00427.x
https://doi.org/10.1046/j.1471-4159.2001.00427.x
Autor:
Igor L. Shamovsky, Mark Solc, Gregory M. Ross, Wei Wang, Rajatavo Maitra, Richard J. Riopelle, Suzanne M. Dostaler, Gail Lawrance
Publikováno v:
Neurotoxicity Research. 2:321-341
Direct effects of Zn2+ on the conformation and biological activity of nerve growth factor (NGF) have previously been described. Zn2+ binds to specific coordination sites within NGF and induces conformational changes within domains that participate in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b886908d709a47accb0daa394944ffd
https://doi.org/10.1007/bf03033341
https://doi.org/10.1007/bf03033341
Autor:
Richard J. Riopelle, Igor L. Shamovsky, Gail Lawrance, Mark Solc, Suzanne M. Dostaler, Gregory M. Ross, Donald F. Weaver
Publikováno v:
European Journal of Neuroscience. 10:890-898
Equilibrium binding of 125I-nerve growth factor (125I-NGF) to cells coexpressing the tyrosine kinase receptor A (TrkA) and common neurotrophin receptor (p75NTR), cells coexpressing both receptors where p75NTR is occupied, and cells expressing only p7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326b318421b3cf008f123dce86506cfe
https://doi.org/10.1046/j.1460-9568.1998.00094.x
https://doi.org/10.1046/j.1460-9568.1998.00094.x
Publikováno v:
Neuroscience letters. 371(2-3)
While corticotropin-releasing hormone (CRH) has been implicated in a variety of brain disorders such as ischemic injury, the molecular mechanism by which CRH elicits its activities is largely unclear. In the present study, we have determined the effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8827c4d0b67ed69e3c09645bc282835
https://pubmed.ncbi.nlm.nih.gov/15519743
https://pubmed.ncbi.nlm.nih.gov/15519743
Publikováno v:
Neurotoxicology. 23(4-5)
Genetic, neurochemical, and environmental factors have been implicated in neurodegenerative disease, and a combination of these factors is likely responsible for disease onset and progression. Environmental toxicants implicated in Parkinson’s disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d3c6ba2d3bceb978bbc801bb959bc6
https://pubmed.ncbi.nlm.nih.gov/12428727
https://pubmed.ncbi.nlm.nih.gov/12428727
Autor:
Sandra L. Jimmo, Donald F. Weaver, Suzanne M. Dostaler, Richard J. Riopelle, Mark Solc, Igor L. Shamovsky, Gail Lawrance, Gregory M. Ross
Publikováno v:
Nature medicine. 3(8)
A role for Zn2+ in a variety of neurological conditions such as stroke, epilepsy and Alzheimer's disease has been postulated. In many instances, susceptible neurons are located in regions rich in Zn2+ where nerve growth factor (NGF) levels rise as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2994b8a87fe2c8c0498fcbc0a93c47e
https://pubmed.ncbi.nlm.nih.gov/9256278
https://pubmed.ncbi.nlm.nih.gov/9256278
Publikováno v:
Brain research. Developmental brain research. 97(1)
Activity-dependent enduring change in cellular communication is essential for specific connectivity during development of the nervous system and for adaptive responses of the mature nervous system. Here we report that glutamate activation of excitato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17674abdffd2472a2cf21d7afd459f0a
https://pubmed.ncbi.nlm.nih.gov/8946051
https://pubmed.ncbi.nlm.nih.gov/8946051