Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Mark Sheehan"'
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-7 (2024)
Abstract There are good practical reasons to use electronic consent (e-consent) in randomised trials, especially when conducting large-scale clinical trials to answer population-level health research questions. However, determining ethical reasons fo
Externí odkaz:
https://doaj.org/article/b35a0ee25f6e4267824b5ba72fc44ca5
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101352- (2024)
Evaluation of host integration profiles by adeno-associated virus (AAV) is an important component of de-risking novel AAV gene therapies. Targeted enrichment sequencing (TES) is a cost-effective and comprehensive method for assessing integration. Mos
Externí odkaz:
https://doaj.org/article/654cd3cfc1ad47d7988230718f57b959
Publikováno v:
Research Ethics Review, Vol 20 (2024)
Many research institutions and funders have recently stated their commitment to actively support and promote ‘Equality, Diversity and Inclusion’ (EDI) in various aspects of health research including Patient and Public Involvement (PPI). However,
Externí odkaz:
https://doaj.org/article/f55ca856bf224352be4a527f023839e4
Autor:
Elias M. Oziolor, Steven W. Kumpf, Jessie Qian, Mark Gosink, Mark Sheehan, David M. Rubitski, Leah Newman, Laurence O. Whiteley, Thomas A. Lanz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 395-405 (2023)
Many current gene therapy targets use recombinant adeno-associated virus (AAV). The majority of delivered AAV therapeutics persist as episomes, separate from host DNA, yet some viral DNA can integrate into host DNA in different proportions and at gen
Externí odkaz:
https://doaj.org/article/408d92ef4a474a9ab96737ca95b99093
Publikováno v:
Wellcome Open Research, Vol 8 (2024)
Background In the aftermath of the Coronavirus disease 2019 (Covid-19) pandemic, allocation of non-urgent medical interventions is a persistent ethical challenge as health systems currently face an unprecedented backlog of patients requiring treatmen
Externí odkaz:
https://doaj.org/article/31fb39a70615441ea422cae0d5e1e4d2
Autor:
Kejie Li, Yu H. Sun, Zhengyu Ouyang, Soumya Negi, Zhen Gao, Jing Zhu, Wanli Wang, Yirui Chen, Sarbottam Piya, Wenxing Hu, Maria I. Zavodszky, Hima Yalamanchili, Shaolong Cao, Andrew Gehrke, Mark Sheehan, Dann Huh, Fergal Casey, Xinmin Zhang, Baohong Zhang
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Background Single-cell RNA sequencing is a state-of-the-art technology to understand gene expression in complex tissues. With the growing amount of data being generated, the standardization and automation of data analysis are critical to gen
Externí odkaz:
https://doaj.org/article/8f534c5f1fa14c889a7b21ee781902e7
A single center 9-year experience in IVC filter retrieval - the importance of an IVC filter registry
Autor:
Mark Sheehan, Kristopher Coppin, Cormac O’Brien, Andrew McGrath, Mark Given, Aoife Keeling, Michael J Lee
Publikováno v:
CVIR Endovascular, Vol 5, Iss 1, Pp 1-6 (2022)
Abstract Background To evaluate Inferior vena cava (IVC) filter retrieval practices over a 9-year period at an academic hospital with a prospectively maintained IVC filter registry. Method An IVC filter registry was maintained prospectively within ou
Externí odkaz:
https://doaj.org/article/81c46de615d6482b9cc9be6f31bd4470
Autor:
Richard Milne, Mark Sheehan, Brendan Barnes, Janek Kapper, Nathan Lea, James N'Dow, Gurparkash Singh, Amelia Martín-Uranga, Nigel Hughes
Publikováno v:
Frontiers in Big Data, Vol 5 (2022)
The ability to use clinical and research data at scale is central to hopes for data-driven medicine. However, in using such data researchers often encounter hurdles–both technical, such as differing data security requirements, and social, such as t
Externí odkaz:
https://doaj.org/article/4e181a2485c4453483fbb4d6101f01bc
Publikováno v:
Health Expectations, Vol 24, Iss S1, Pp 54-61 (2021)
Abstract Context Both within politics and practice, the field of psychiatry is undergoing a significant transformation, as increasing emphasis is placed on the importance of involving those with lived experience in research. In response to this parti
Externí odkaz:
https://doaj.org/article/64e919e443f4406baa3abc7b29999b17
Autor:
Agata Ferretti, Marcello Ienca, Mark Sheehan, Alessandro Blasimme, Edward S. Dove, Bobbie Farsides, Phoebe Friesen, Jeff Kahn, Walter Karlen, Peter Kleist, S. Matthew Liao, Camille Nebeker, Gabrielle Samuel, Mahsa Shabani, Minerva Rivas Velarde, Effy Vayena
Publikováno v:
BMC Medical Ethics, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Ethics review is the process of assessing the ethics of research involving humans. The Ethics Review Committee (ERC) is the key oversight mechanism designated to ensure ethics review. Whether or not this governance mechanism is st
Externí odkaz:
https://doaj.org/article/70ddcc77999a449d9508f252e88b1b75