Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mark Sevecka"'
Autor:
Beni B. Wolf, Ulrik B. Nielsen, Jonathan B. Fitzgerald, Anne M. King, Callum M. Sloss, Olga Burenkova, Neeraj Kohli, Shannon L. Werner, Nastaran Gerami-Moayed, Gege Tan, Mark Sevecka, Raghida Bukhalid, Jeffrey D. Kearns
Supplementary Methods, Figures S1-S11, and Table Legends. Supplementary Methods: description of methods used in the Supplementary figures, expanded description of ELISA assays, and description of the computational model of multiple EGFR ligand antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0589dd9379473a98d20e9845ac6751
https://doi.org/10.1158/1535-7163.22501833.v1
https://doi.org/10.1158/1535-7163.22501833.v1
Autor:
Beni B. Wolf, Ulrik B. Nielsen, Jonathan B. Fitzgerald, Anne M. King, Callum M. Sloss, Olga Burenkova, Neeraj Kohli, Shannon L. Werner, Nastaran Gerami-Moayed, Gege Tan, Mark Sevecka, Raghida Bukhalid, Jeffrey D. Kearns
Supplementary Tables S2, S3, S4. Structure of the computational model of multiple ligand antagonists: species (Table S2), parameters (Table S3), and Reactions (Table S4).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c534d560032452e0b5101eea8d16d10b
https://doi.org/10.1158/1535-7163.22501827
https://doi.org/10.1158/1535-7163.22501827
Autor:
Beni B. Wolf, Ulrik B. Nielsen, Jonathan B. Fitzgerald, Anne M. King, Callum M. Sloss, Olga Burenkova, Neeraj Kohli, Shannon L. Werner, Nastaran Gerami-Moayed, Gege Tan, Mark Sevecka, Raghida Bukhalid, Jeffrey D. Kearns
Supplementary Table S1. Cell lines and cell culture conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0501a563d004db70756494b7092751e4
https://doi.org/10.1158/1535-7163.22501830
https://doi.org/10.1158/1535-7163.22501830
Autor:
Beni B. Wolf, Ulrik B. Nielsen, Jonathan B. Fitzgerald, Anne M. King, Callum M. Sloss, Olga Burenkova, Neeraj Kohli, Shannon L. Werner, Nastaran Gerami-Moayed, Gege Tan, Mark Sevecka, Raghida Bukhalid, Jeffrey D. Kearns
Supplementary Tables S5, S6, S7, S8. mRNA expression data for EGFR ligands as measured by RNAseq from The Cancer Genome Atlas (TCGA) across 14 cancer indications or by RT-qPCR of colorectal cancer FFPE samples. Table S5: Summary of TCGA datasets incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5782fe1fa8c256671852ceadb513a3f4
https://doi.org/10.1158/1535-7163.22501824
https://doi.org/10.1158/1535-7163.22501824
Autor:
Jens Timmer, Violette Paragas, Mark Sevecka, John E. Allen, Emily Pace, Joerg Stelling, Gavin MacBeath, Helge Hass, Kristina Masson, Birgit Schoeberl, Sibylle Wohlgemuth, Andreas Raue
Publikováno v:
npj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-15 (2017)
NPJ Systems Biology and Applications
npj Systems Biology and Applications, 3
NPJ Systems Biology and Applications
npj Systems Biology and Applications, 3
Targeted therapies have shown significant patient benefit in about 5–10% of solid tumors that are addicted to a single oncogene. Here, we explore the idea of ligand addiction as a driver of tumor growth. High ligand levels in tumors have been shown
Autor:
Neeraj Kohli, Olga Burenkova, Mark Sevecka, Ulrik B. Nielsen, Nastaran Gerami-Moayed, Callum M. Sloss, Raghida Bukhalid, Jonathan Fitzgerald, Beni B. Wolf, Shannon L. Werner, Jeffrey D. Kearns, Gege Tan, Anne M. King
Publikováno v:
Molecular Cancer Therapeutics. 14:1625-1636
Although EGFR is a validated therapeutic target across multiple cancer indications, the often modest clinical responses to current anti-EGFR agents suggest the need for improved therapeutics. Here, we demonstrate that signal amplification driven by h
Autor:
Gavin MacBeath, Kristina Masson, Violette Paragas, Joerg Stelling, John E. Allen, Mark Sevecka, Jens Timmer, Emily Pace, Birgit Schoeberl, Helge Hass, Andreas Raue, Sibylle Wohlgemuth
Publikováno v:
Cancer Research. 78:1312-1312
Receptor tyrosine kinases (RTKs) are high-affinity cell surface receptors for growth factors that are frequently deregulated in cancer. Signaling through these receptors has been associated with increased cancer cell proliferation and resistance to c
Publikováno v:
Current Opinion in Chemical Biology. 13:398-405
Although many methods exist to study the recognition and signaling properties of proteins in isolation, it remains a challenge to perform these investigations on a system-wide or proteome-wide scale and within the context of biological complexity. Pr
Autor:
Gavin MacBeath, Mark Sevecka
Publikováno v:
Nature Methods. 3:825-831
As an alternative to conventional, target-oriented drug discovery, we report a strategy that identifies compounds on the basis of the state that they induce in a signaling network. Immortalized human cells are grown in microtiter plates and treated w
Autor:
Alejandro Wolf-Yadlin, Mark Sevecka, Gavin MacBeath, David E. Root, Douglas A. Lauffenburger, Jennifer K. Grenier, Joel P. Wagner
Publikováno v:
PMC
Although many anticancer drugs that target receptor tyrosine kinases (RTKs) provide clinical benefit, their long-term use is limited by resistance that is often attributed to increased abundance or activation of another RTK that compensates for the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f75f52ea9a19bbb960bfb5274302015
https://europepmc.org/articles/PMC3987808/
https://europepmc.org/articles/PMC3987808/