Zobrazeno 1 - 10
of 655
pro vyhledávání: '"Mark S.P. Sansom"'
Autor:
Emma Rose McGlone, T. Bertie Ansell, Cecilia Dunsterville, Wanling Song, David Carling, Alejandra Tomas, Stephen R. Bloom, Mark S.P. Sansom, Tricia Tan, Ben Jones
Publikováno v:
Molecular Metabolism, Vol 63, Iss , Pp 101530- (2022)
Structured abstract: Objective: To determine whether glucagon receptor (GCGR) actions are modulated by cellular cholesterol levels. Methods: We determined the effects of experimental cholesterol depletion and loading on glucagon-mediated cAMP product
Externí odkaz:
https://doaj.org/article/30118452e1cf4e4dad65c30c5ab019ba
Autor:
Anna-Lisa Lanz, Giulia Masi, Nicla Porciello, André Cohnen, Deborah Cipria, Dheeraj Prakaash, Štefan Bálint, Roberto Raggiaschi, Donatella Galgano, David K. Cole, Marco Lepore, Omer Dushek, Michael L. Dustin, Mark S.P. Sansom, Antreas C. Kalli, Oreste Acuto
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109531- (2021)
Externí odkaz:
https://doaj.org/article/a6cb432e0b0a4011bea51b73db0ce5dd
Autor:
Linda X. Phan, Victor Cruces Chamorro, Hector Martinez-Seara, Jason Crain, Mark S.P. Sansom, Stephen J. Tucker
Publikováno v:
Biophysical Journal. 122:1548-1556
The functional properties of some biological ion channels and membrane transport proteins are proposed to exploit anion-hydrophobic interactions. Here, we investigate a chloride-pumping rhodopsin (ClR) as an example of a membrane protein known to con
Publikováno v:
Biophysical Journal. 122:112a-113a
Publikováno v:
Current Opinion in Structural Biology. 80:102589
Autor:
Wanling Song, Alejandra Tomas, Ben Jones, Tricia Tan, T. B. Ansell, Mark S.P. Sansom, Emma Rose McGlone, David Carling, Stephen R. Bloom, C. Dunsterville
Publikováno v:
Molecular metabolism. 63
Objective To determine whether glucagon receptor (GCGR) actions are modulated by cellular cholesterol levels. Methods We determined the effects of experimental cholesterol depletion and loading on glucagon-mediated cAMP production, ligand internalisa
Autor:
T. Schwarz, Mark S.P. Sansom, Robert Konrat, Benjamin P. Cossins, Terry Baker, Richard J. K. Taylor, J. Shih, S.-B. Amos
Publikováno v:
The Journal of Physical Chemistry. B
α-Synuclein (αS) is a presynaptic protein that binds to cell membranes and is linked to Parkinson’s disease (PD). Binding of αS to membranes is a likely first step in the molecular pathophysiology of PD. The αS molecule can adopt multiple confo
Publikováno v:
The Journal of Physical Chemistry. B
Ion channels are proteins which form gated nanopores in biological membranes. Many channels exhibit hydrophobic gating, whereby functional closure of a pore occurs by local dewetting. The pentameric ligand gated ion channels (pLGICs) provide a biolog
Autor:
Mark S.P. Sansom, Alexis Belessiotis-Richards, Molly M. Stevens, Alfredo Alexander-Katz, Stuart G. Higgins
Publikováno v:
ACS Nano
Nanoscale membrane curvature is a common feature in cell biology required for functions such as endocytosis, exocytosis and cell migration. These processes require the cytoskeleton to exert forces on the membrane to deform it. Cytosolic proteins cont
Autor:
Tim Rasmussen, Akiko Rasmussen, Rainer Hedrich, Renato Zenobi, Shanlin Rao, Bettina Böttcher, Vanessa Judith Flegler, Mark S.P. Sansom, Na Wu
Publikováno v:
Proc Natl Acad Sci U S A
The mechanosensitive channel of small conductance (MscS) is the prototype of an evolutionarily diversified large family that fine-tunes osmoregulation but is likely to fulfill additional functions. Escherichia coli has six osmoprotective paralogs wit