Výsledky vyhledávání - "Mark S. Washburn"

UB-165: A Novel Nicotinic Agonist with Subtype Selectivity Implicates the α4β2* Subtype in the Modulation of Dopamine Release from Rat Striatal Synaptosomes

Autor: Christopher G. V. Sharples, Susan Wonnacott, Timothy Gallagher, James Spencer, Mark S. Washburn, Paul Whiteaker, Sergio Kaiser, L. Soliakov, Emma Wright, Allan C. Collins, Michael J. Marks

Publikováno v: The Journal of Neuroscience. 20:2783-2791

Presynaptic nicotinic acetylcholine receptors (nAChRs) on striatal synaptosomes stimulate dopamine release. Partial inhibition by the α3β2-selective α-conotoxin-MII indicates heterogeneity of presynaptic nAChRs on dopamine terminals. We have used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb189cede080e8182a5b211964c88ab4
https://doi.org/10.1523/jneurosci.20-08-02783.2000

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Structure and Functional Characterization of a Novel Human Low-Voltage Activated Calcium Channel

Autor: Kenneth A. Stauderman, Arturo Urrutia, Michael M. Harpold, Paul Brust, Mark E. Williams, Patricia Prodanovich, Michael Hans, Mark S. Washburn

Publikováno v: Journal of Neurochemistry. 72:791-799

We have isolated and characterized overlapping cDNAs encoding a novel, voltage-gated Ca2+ channel alpha1 subunit, alpha1H, from a human medullary thyroid carcinoma cell line. The alpha1H subunit is structurally similar to previously described alpha1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ae0425322000fedbde2436f2353fbf
https://doi.org/10.1046/j.1471-4159.1999.0720791.x

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Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition

Autor: David D. Mott, Polina Lyuboslavsky, Mark S. Washburn, Stephen F. Traynelis, Sunan Zhang, James J. Doherty, Raymond Dingledine, Morris J. Fendley

Publikováno v: Nature Neuroscience. 1:659-667

The phenylethanolamines, ifenprodil and CP-101,606, are NMDA receptor antagonists with promising neuroprotective properties. In recombinant NMDA receptors expressed in Xenopus oocytes, we found that these drugs inhibit NMDA receptors through a unique

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6132f7105ebdcafc24f2ac3c6d54dbeb
https://doi.org/10.1038/3661

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Subunit-Dependent Modulation of Kainate Receptors by Extracellular Protons and Polyamines

Autor: David D. Mott, Sunan Zhang, Raymond Dingledine, Mark S. Washburn

Synaptic activity causes significant fluctuations in proton concentrations in the brain. Changes in pH can affect neuronal excitability by acting on ligand-gated channels, including those gated by glutamate. We show here a subunit-dependent regulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fb1032da654e4673143b1693ee4037
https://europepmc.org/articles/PMC6742282/

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3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity

Autor: Jesse Brodkin, Jeffrey Roger Roppe, Linda J. Bristow, Jeffrey Anderson, Edwin J. Schweiger, Lida Tehrani, Mark S. Washburn, Ian A. McDonald, Sara Rao, Xiaohui Jiang, Nicholas D. P. Cosford, Mark A. Varney, Nicholas D. Smith

Publikováno v: Journal of medicinal chemistry. 46(2)

2-Methyl-6-(phenylethynyl)pyridine (3), a potent noncompetitive mGlu5 receptor antagonist widely used to characterize the pharmacology of mGlu5 receptors, suffers from a number of shortcomings as a therapeutic agent, including off-target activity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d27cfade402b20125b94652651c157c
https://pubmed.ncbi.nlm.nih.gov/12519057

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Recombinant human receptors and functional assays in the discovery of altinicline (SIB-1508Y), a novel acetylcholine-gated ion channel (nAChR) agonist

Autor: Carla Suto, Tadimeti S. Rao, Ian A. McDonald, Robert Siegel, Jean-Michel Vernier, G. Kenneth Lloyd, Laura E. Chavez-Noriega, Nicholas D. P. Cosford, Leo Bleicher, Mark S. Washburn

Publikováno v: Pharmaceutica acta Helvetiae. 74(2-3)

Neuronal nicotinic acetylcholine receptors (nAChRs) are a class of ion channels with significant potential as molecular targets for the design of drugs to treat a variety of CNS disorders. The discovery that neuronal nAChRs are further subdivided int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a07d1745fce7ead20c149103f9e299
https://pubmed.ncbi.nlm.nih.gov/10812948

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Conformationally restricted analogues of nicotine and anabasine

Autor: Tadimeti S. Rao, G. Kenneth Lloyd, Jean-Michel Vernier, Nicholas D. P. Cosford, Laura E. Chavez-Noriega, Frédérique Menzaghi, Arturo Urrutia, Carla Suto, Heather Holsenback, Aida I. Sacaan, Ian A. McDonald, Mark S. Washburn, Jeffrey P. Whitten, R. T. Reid

Publikováno v: Bioorganicmedicinal chemistry letters. 8(16)

A series of conformationally restricted analogues of nicotine has been synthesized and evaluated as agonists of neuronal acetylcholine receptors. Compound 2 (SIB-1663), which selectively activated human recombinant alpha 2 beta 4 and alpha 4 beta 4 n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2178f568ace913b70d0f413355174731
https://pubmed.ncbi.nlm.nih.gov/9873508

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The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents

Autor: Nicholas D. P. Cosford, Jean-Michel Vernier, Tadimeti S. Rao, Gonul Velicelebi, Aida I. Sacaan, M.M. Harpold, Robert Siegel, Frederique Menzaghi, K. A. Stauderman, Laura E. Chavez-Noriega, L.A. McDonald, Bruno Bontempi, Edwin C. Johnson, Carla Suto, M. Akong, Mark S. Washburn, G. K. Lloyd

Publikováno v: Life sciences. 62(17-18)

Neuronal nicotinic acetylcholine receptors (NAChRs) are pentameric ligand-gated ion channel receptors which exist as different functional subunit combinations which apparently subserve different physiological functions as indicated by molecular biolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472b3281d993b8d69a1ceb58819e07f1
https://pubmed.ncbi.nlm.nih.gov/9585143

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Differential Dependence on GluR2 Expression of Three Characteristic Features of AMPA Receptors

Autor: Mark S. Washburn, Sunan Zhang, Raymond Dingledine, Markus Numberger

The GluR2 subunit controls three key features of ion flux through the AMPA subtype of glutamate receptors—calcium permeability, inward rectification, and channel block by external polyamines, but whether each of these features is equally sensitive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f72cedb489d2295fa580e62498e219e
https://europepmc.org/articles/PMC6573423/

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