Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mark S. Tichenor"'
Autor:
Mark S. Tichenor, John J. M. Wiener, Navin L. Rao, Genesis M. Bacani, Jianmei Wei, Charlotte Pooley Deckhut, J. Kent Barbay, Kevin D. Kreutter, Leon Chang, Kathleen W. Clancy, Heather E. Murrey, Weixue Wang, Kay Ahn, Michael Huber, Elizabeth Rex, Kevin J. Coe, Jiejun Wu, Haopeng Rui, Kia Sepassi, Marcello Gaudiano, Mariette Bekkers, Ivo Cornelissen, Kathryn Packman, Mark Seierstad, Christos Xiouras, Scott D. Bembenek, Richard Alexander, Cynthia Milligan, Sriram Balasubramanian, Alec D. Lebsack, Jennifer D. Venable, Ulrike Philippar, James P. Edwards, Gavin Hirst
Publikováno v:
Journal of Medicinal Chemistry. 65:14326-14336
Bruton's tyrosine kinase (BTK) is a Tec family kinase that plays an essential role in B-cell receptor (BCR) signaling as well as Fcγ receptor signaling in leukocytes. Pharmacological inhibition of BTK has been shown to be effective in treating hemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b6932f837c19dc6e82c72e8534354a
https://doi.org/10.1021/acs.jmedchem.2c01026
https://doi.org/10.1021/acs.jmedchem.2c01026
Autor:
Jennifer D. Venable, Weixue Wang, Jianmei Wei, Heather E. Murrey, Mark S. Tichenor, Kristi A. Leonard, Michael Huber, Alec D. Lebsack, Genesis M. Bacani, Scott D. Bembenek, Kay Ahn, J. Kent Barbay, Leon Chang, Kevin D. Kreutter, Navin Rao, Charlotte Pooley Deckhut, Jiejun Wu, Kevin J. Coe, Elizabeth B. Rex, John J. M. Wiener, James P. Edwards, Mark Seierstad
Publikováno v:
ACS Med Chem Lett
[Image: see text] Bruton’s tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase that plays a critical role in the activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types in the pathology of autoimmune disorders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422ec59592fb7660a28bf2fbdb3405aa
https://doi.org/10.1021/acsmedchemlett.1c00044
https://doi.org/10.1021/acsmedchemlett.1c00044
Autor:
Eduardo V. Mercado-Marin, Jim Na, Renee L. DesJarlais, Helena C. Steffens, Genesis M. Bacani, Mark Seierstad, De Michael Chung, Taraneh Mirzadegan, Mark S. Tichenor
Publikováno v:
ACS Med Chem Lett
[Image: see text] Drug discovery building blocks available commercially or within an internal inventory cover a diverse range of chemical space and yet describe only a tiny fraction of all chemically feasible reagents. Vendors will eagerly provide to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e8eae69e6bffcbc5c1849a0bd619e3
https://europepmc.org/articles/PMC8591720/
https://europepmc.org/articles/PMC8591720/
Autor:
Kristi A. Leonard, Kevin D. Kreutter, Suzie Kim, Tadimeti S. Rao, Michael C. Harris, Wenying Chai, Tatiana Koudriakova, Paul J. Krawczuk, Russell C. Smith, James P. Edwards, Mark Seierstad, Marguerite E. Johnson, Lisa Madge, Jennifer D. Venable, Gavin C. Hirst, Genesis M. Bacani, Aihua Wang, Ravi Malaviya, Mark S. Tichenor, Michele C. Rizzolio, Ashok S. Mathur
Publikováno v:
Journal of medicinal chemistry. 63(6)
To identify Janus kinase (JAK) inhibitors that selectively target gastrointestinal tissues with limited systemic exposures, a class of imidazopyrrolopyridines with a range of physical properties was prepared and evaluated. We identified compounds wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c7f6dc6bca7939f0adbd0515e0e729
https://pubmed.ncbi.nlm.nih.gov/32134643
https://pubmed.ncbi.nlm.nih.gov/32134643
Publikováno v:
Journal of Medicinal Chemistry. 58:7119-7127
Histamine is an important endogenous signaling molecule that is involved in a number of physiological processes including allergic reactions, gastric acid secretion, neurotransmitter release, and inflammation. The biological effects of histamine are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4382a034e1f4046af526754b0bc620fa
https://doi.org/10.1021/acs.jmedchem.5b00516
https://doi.org/10.1021/acs.jmedchem.5b00516
Autor:
Sandy J. Wilson, Brian Scott, Mark S. Tichenor, Michele C. Rizzolio, Sandra R. Chaplan, Michael Webb, James A. Palmer, J. Guy Breitenbucher, Michelle L. Wennerholm, Raymond Rynberg, Mark Seierstad, Wei Xiao, Mark J. Karbarz, Richard Apodaca, John M. Keith, William M. Jones, Joan Pierce
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(13)
The SAR of brain penetration for a series of heteroaryl piperazinyl- and piperadinyl-urea fatty acid amide hydrolase (FAAH) inhibitors is described. Brain/plasma (B/P) ratios ranging from >4:1 to as low as 0.02:1 were obtained through relatively simp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ae76e3b864bc6dbfc824e2ac203ac5
https://pubmed.ncbi.nlm.nih.gov/27189675
https://pubmed.ncbi.nlm.nih.gov/27189675
Autor:
Dale L. Boger, Mark S. Tichenor
Publikováno v:
Nat. Prod. Rep.. 25:220-226
Covering: up to 2007 DNA-binding small molecules are an important source of anticancer therapeutics that display a diverse array of mechanisms of action. Synthetic studies on the new DNA-alkylating natural product yatakemycin, detailed in this Highli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2d7ee792133d7023cfc16ff12583f8
https://doi.org/10.1039/b705665f
https://doi.org/10.1039/b705665f
Autor:
John M. Keith, Sandy J. Wilson, Michelle L. Wennerholm, William M. Jones, Raymond Rynberg, Leon Chang, Breitenbucher Jg, Jing Liu, Michael Webb, Lin Luo, Brian Scott, Mark S. Tichenor, Michele C. Rizzolio, Chaplan, James A. Palmer, Mark J. Karbarz, Mark Seierstad
Publikováno v:
ACS medicinal chemistry letters. 6(12)
The pre-clinical characterization of the aryl piperazinyl urea inhibitor of fatty acid amide hydrolase (FAAH) JNJ-42165279 is described. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4078e5fe9c66c21caee1f97bc3ebf2b0
https://pubmed.ncbi.nlm.nih.gov/26713105
https://pubmed.ncbi.nlm.nih.gov/26713105
Publikováno v:
Journal of medicinal chemistry. 58(18)
Histamine is an important endogenous signaling molecule that is involved in a number of physiological processes including allergic reactions, gastric acid secretion, neurotransmitter release, and inflammation. The biological effects of histamine are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25b48478c72dcdc51dd086521567b3f0
https://pubmed.ncbi.nlm.nih.gov/25993395
https://pubmed.ncbi.nlm.nih.gov/25993395
Autor:
David B. Kastrinsky, Dale L. Boger, Futoshi Shiga, Inkyu Hwang, John David Trzupek, Mark S. Tichenor
Publikováno v:
Journal of the American Chemical Society. 128:15683-15696
Complementary to studies that provided the first yatakemycin total synthesis resulting in its structure revision and absolute stereochemistry assignment, a second-generation asymmetric total synthesis is disclosed herein. Since the individual yatakem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b36d1680214262a0e465da82b56081b
https://doi.org/10.1021/ja064228j
https://doi.org/10.1021/ja064228j