Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mark S. T. Hansen"'
Autor:
Amaury Vaysse, Abhirami Ratnakumar, Thomas Derrien, Erik Axelsson, Gerli Rosengren Pielberg, Snaevar Sigurdsson, Tove Fall, Eija H Seppälä, Mark S T Hansen, Cindy T Lawley, Elinor K Karlsson, LUPA Consortium, Danika Bannasch, Carles Vilà, Hannes Lohi, Francis Galibert, Merete Fredholm, Jens Häggström, Ake Hedhammar, Catherine André, Kerstin Lindblad-Toh, Christophe Hitte, Matthew T Webster
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002316 (2011)
The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique population history accompanied by selection for novel and desirable traits. Here we perform a comprehensive analysis using multiple test statistics to identify regions
Externí odkaz:
https://doaj.org/article/d1a5788aface4f22b8302a117fd49479
Publikováno v:
Nature Medicine. 7:631-634
Early steps of infection by HIV-1 involve entry of the viral core into cells, reverse transcription to form the linear viral DNA, and integration of that DNA into a chromosome of the host. The unintegrated DNA can also follow non-productive pathways,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f3e73890e83c98b8d333c5735d291f
https://doi.org/10.1038/87979
https://doi.org/10.1038/87979
Autor:
Ling Li, Jennifer M. Olvera, Mark S. T. Hansen, Kristine E. Yoder, Frederic D. Bushman, Michael D. Miller
Publikováno v:
Journal of Virology. 74:10965-10974
To replicate, a retrovirus must synthesize a cDNA copy of the viral RNA genome and integrate that cDNA into a chromosome of the host. We have investigated the role of a host cell cofactor, HMG I(Y) protein, in integration of human immunodeficiency vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ae5b309672ec4245c0297833e96add
https://doi.org/10.1128/jvi.74.23.10965-10974.2000
https://doi.org/10.1128/jvi.74.23.10965-10974.2000
Autor:
Mark S. T. Hansen, Frederic D. Bushman
Publikováno v:
Journal of Virology. 71:3351-3356
We have established an assay for the function of preintegration complexes (PICs) of human immunodeficiency virus type 2 (HIV-2) to investigate the integration mechanism and to develop additional methods for screening candidate integration inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90645d88abf09386a65d3038f01323b9
https://doi.org/10.1128/jvi.71.4.3351-3356.1997
https://doi.org/10.1128/jvi.71.4.3351-3356.1997
Autor:
Kathleen Rubins, Valentina Molteni, Mark S. T. Hansen, Frederic D. Bushman, Jay S. Siegel, Denise Rhodes
Publikováno v:
ChemInform. 31
Integration is a required step in HIV replication, but as yet no inhibitors of the integration step have been developed for clinical use. Many inhibitors have been identified that are active against purified viral-encoded integrase protein; of these,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06e1232d3a7f9624a6770f5ea8b67859
https://doi.org/10.1002/chin.200033097
https://doi.org/10.1002/chin.200033097
Autor:
William Fenical, Frederic D. Bushman, Mark S. T. Hansen, J. Andrew McCammon, David C. Rowley, Haihong Ni, Christoph A. Sotriffer, Denise Rhodes
Publikováno v:
ChemInform. 34
Human immunodeficiency virus (HIV) replication requires integration of viral cDNA into the host genome, a process mediated by the viral enzyme integrase. We describe a new series of HIV integrase inhibitors, thalassiolins A-C (1-3), isolated from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069b0b10e0b8539bc2676a6980f56dcd
https://doi.org/10.1002/chin.200303213
https://doi.org/10.1002/chin.200303213
Autor:
Denise Rhodes, Mark S. T. Hansen, Jay S. Siegel, Frederic D. Bushman, Valentina Molteni, Kathleen Rubins
Publikováno v:
Journal of medicinal chemistry. 43(10)
Integration is a required step in HIV replication, but as yet no inhibitors of the integration step have been developed for clinical use. Many inhibitors have been identified that are active against purified viral-encoded integrase protein; of these,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6833fe34e865f0f19d57bb8fa38e5805
https://pubmed.ncbi.nlm.nih.gov/10821715
https://pubmed.ncbi.nlm.nih.gov/10821715
Autor:
Tal Kafri, Jay S. Siegel, Mark S. T. Hansen, George J. Smith, Valentina Molteni, Frederic D. Bushman
Publikováno v:
Nature biotechnology. 17(6)
Of three enzymes encoded by HIV–reverse transcriptase, protease, and integrase—only the first two have been exploited clinically as inhibitor targets. Efforts to develop inhibitors of purified integrase protein have yielded many compounds, but no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362375703a2084983e7dbcbb78b71f09
https://pubmed.ncbi.nlm.nih.gov/10385323
https://pubmed.ncbi.nlm.nih.gov/10385323
Autor:
W. E. Robinson, Jay S. Siegel, Chris M. Farnet, Frederic D. Bushman, J. R. Lipford, L. Zalkow, Mark S. T. Hansen, B. Wang
Publikováno v:
Antimicrobial agents and chemotherapy. 42(9)
Integration of the human immunodeficiency virus type 1 (HIV-1) cDNA is a required step for viral replication. Integrase, the virus-encoded enzyme important for integration, has not yet been exploited as a target for clinically useful inhibitors. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b907c3d8aff88ddec252823de80124a3
https://pubmed.ncbi.nlm.nih.gov/9736543
https://pubmed.ncbi.nlm.nih.gov/9736543
Publikováno v:
Genetic Engineering ISBN: 9781489917416
Retroviruses such as human immunodeficiency virus (HIV) are distinguished from other viruses by the combination of two steps in the viral life cycle. The first is reverse transcription, which results in the production of a cDNA copy of the viral RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6d6c03af9a75b6c28f4d8ac3088fe8c
https://doi.org/10.1007/978-1-4899-1739-3_3
https://doi.org/10.1007/978-1-4899-1739-3_3
