Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Mark S. Sundrud"'
Autor:
Koichi Sudo, Amber Delmas-Eliason, Shannon Soucy, Kaitlyn E. Barrack, Jiabao Liu, Akshaya Balasubramanian, Chengyi Jenny Shu, Michael J. James, Courtney L. Hegner, Henry D. Dionne, Alex Rodriguez-Palacios, Henry M. Krause, George A. O’Toole, Saul J. Karpen, Paul A. Dawson, Daniel Schultz, Mark S. Sundrud
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 6, Pp 101392- (2024)
Backgrounds & Aims: Bile acids (BAs) are core gastrointestinal metabolites with dual functions in lipid absorption and cell signaling. BAs circulate between the liver and distal small intestine (i.e., ileum), yet the dynamics through which complex BA
Externí odkaz:
https://doaj.org/article/4c920e38c9f24de48d0c7062be6a9281
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Nearly 50 ATP-binding cassette (ABC) transporters are encoded by mammalian genomes. These transporters are characterized by conserved nucleotide-binding and hydrolysis (i.e., ATPase) domains, and power directional transport of diverse substrate class
Externí odkaz:
https://doaj.org/article/111bc034f5fd4decba52f29b5ecba7cf
Autor:
Ran Wang, Sean Campbell, Mohammed Amir, Sarah A. Mosure, Molly A. Bassette, Amber Eliason, Mark S. Sundrud, Theodore M. Kamenecka, Laura A. Solt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Unlike RORα, which has been thought to be somewhat redundant, RORγt has been well characterized in its function and contribution to the development of Th17 cells. Here the authors show that RORα is important in Th17 differentiation and that RORα
Externí odkaz:
https://doaj.org/article/73087ff786264483a5b440dbda18a0f9
Autor:
Abigail R. Basson, Christy Chen, Filip Sagl, Ashley Trotter, Ilya Bederman, Adrian Gomez-Nguyen, Mark S. Sundrud, Sanja Ilic, Fabio Cominelli, Alex Rodriguez-Palacios
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
With the epidemic of human obesity, dietary fats have increasingly become a focal point of biomedical research. Epidemiological studies indicate that high-fat diets (HFDs), especially those rich in long-chain saturated fatty acids (e.g., Western Diet
Externí odkaz:
https://doaj.org/article/9162faf0dac8426085b884c127ea50cd
Publikováno v:
PLoS ONE, Vol 5, Iss 1 (2010)
Externí odkaz:
https://doaj.org/article/e0fea44c48644ede97365370bba072f3
Autor:
Nicholas P. Restifo, Douglas T. Fearon, Steven A. Rosenberg, Christopher A. Klebanoff, Mark S. Sundrud, Pawel Muranski, Luca Gattinoni, Francesco M. Marincola, Ena Wang, Nicolas Acquavella, Anthony Leonardi, Trevor Upham, Ryan D. Michalek, Sid P. Kerkar, Douglas C. Palmer, Zhiya Yu, Ken-ichi Hanada, Eric Tran, Robert L. Eil, Alena Gros, David Clever, Rahul Roychoudhuri, Madhusudhanan Sukumar, Joseph G. Crompton
Supplemental Figure S4. Akti-treated tumor-specific Pmel CD8+ T cell have reduced phosphorylation of Akt and substrates in presence of pharmacologic inhibition of Akt.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bf35d07ce15c74ea0203064f3435e4
https://doi.org/10.1158/0008-5472.22408146.v1
https://doi.org/10.1158/0008-5472.22408146.v1
Autor:
Nicholas P. Restifo, Douglas T. Fearon, Steven A. Rosenberg, Christopher A. Klebanoff, Mark S. Sundrud, Pawel Muranski, Luca Gattinoni, Francesco M. Marincola, Ena Wang, Nicolas Acquavella, Anthony Leonardi, Trevor Upham, Ryan D. Michalek, Sid P. Kerkar, Douglas C. Palmer, Zhiya Yu, Ken-ichi Hanada, Eric Tran, Robert L. Eil, Alena Gros, David Clever, Rahul Roychoudhuri, Madhusudhanan Sukumar, Joseph G. Crompton
Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) results in complete regression of advanced cancer in some patients, but the efficacy of this potentially curative therapy may be limited by poor persistence of TIL afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d30cf163157e16519ea315f366777c8
https://doi.org/10.1158/0008-5472.c.6507471.v1
https://doi.org/10.1158/0008-5472.c.6507471.v1
Autor:
Rita, Fuerst, Jun Yong, Choi, Anna M, Knapinska, Michael D, Cameron, Claudia, Ruiz, Amber, Delmas, Mark S, Sundrud, Gregg B, Fields, William R, Roush
Publikováno v:
Bioorganicmedicinal chemistry letters. 76
Starting from an already known MMP-13 inhibitor, 1, we pursued an SAR-approach focusing on optimizing interactions close to the Zn
Autor:
Xiangsheng Huang, HaJeung Park, Deborah Schady, Alexander Rodriguez-Palacios, Guohui Wang, Mei Lan Chen, Yujin Liu, Casey T. Weaver, Douglas J. Kojetin, Amber Eliason, David D. Moore, Jinsai Shang, Matthew E. Pipkin, Huitian Diao, Blake Frey, Laura A. Solt, Mark S. Sundrud, Courtney Hegner, Hongtao Wang, Sarah A. Mosure
Publikováno v:
Nature
Bile acids are lipid-emulsifying metabolites synthesized in hepatocytes and maintained in vivo through enterohepatic circulation between the liver and small intestine1. As detergents, bile acids can cause toxicity and inflammation in enterohepatic ti
Autor:
Amber Eliason, Laura A. Solt, Ran Wang, Sarah A. Mosure, Sean Campbell, Mohammed Amir, Theodore M. Kamenecka, Mark S. Sundrud, Molly A. Bassette
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Full development of IL-17 producing CD4+ T helper cells (TH17 cells) requires the transcriptional activity of both orphan nuclear receptors RORα and RORγt. However, RORα is considered functionally redundant to RORγt; therefore, the function and t