Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Mark S. Plummer"'
Autor:
Steven H. Liang, Jinshan Michael Chen, Marc D. Normandin, Jeanne S. Chang, George C. Chang, Christine K. Taylor, Patrick Trapa, Mark S. Plummer, Kimberly S. Para, Edward L. Conn, Lori Lopresti‐Morrow, Lorraine F. Lanyon, James M. Cook, Karl E. G. Richter, Charlie E. Nolan, Joel B. Schachter, Fouad Janat, Ye Che, Veerabahu Shanmugasundaram, Bruce A. Lefker, Bradley E. Enerson, Elijahu Livni, Lu Wang, Nicolas J. Guehl, Debasis Patnaik, Florence F. Wagner, Roy Perlis, Edward B. Holson, Stephen J. Haggarty, Georges El Fakhri, Ravi G. Kurumbail, Neil Vasdev
Publikováno v:
Angewandte Chemie. 128:9753-9757
Autor:
Rose Barham, Thuy Hoang, Jeremy T. Starr, Jennifer A. Young, M. Megan Lemmon, Joseph Penzien, Mark J. Mitton-Fry, Thomas M. Harris, Antonia A. Nikitenko, Brian S. Gerstenberger, Sandra P. McCurdy, Veerabahu Shanmugasundaram, Lisa Mullins, Joel R. Hardink, Jeffrey M. Casavant, Eric S. Marr, Jian Lin, Seungil Han, Joel T. Arcari, John P. Mueller, Brandon P. Schuff, Mark S. Plummer, Craig J. McPherson, Michael D. Huband, Mark C. Noe, Manjinder S. Lall, Richard P. Zaniewski, Chao Li, Matthew Frank Brown, Jianmin Sun, Eric B. McElroy, Andrew P. Tomaras
Publikováno v:
Journal of Medicinal Chemistry. 56:5541-5552
Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa , Klebsiella p
Autor:
Ron Sarver, Christopher Whitehead, Heidi Baum, James Hicks, Richard Gowan, Brian Sanchez, Xiao Kang Lu, Susan E. Bove, Joseph A. Cornicelli, Howard Miller, Sandra Lightle, Aurash B Shahripour, Katherine Welch, Craig Banotai, Jayvardhan Pandit, Mark S. Plummer, Timothy Braden, David Beidler, Adam Ogden, Skalitzky Donald James, Annise Paige Goodman, Howard Roark, Nalini Sadagopan, Charles J. Stankovic, Cindy Spessard, Xi Qiang Shen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3438-3442
We identified potent, selective PDE2 inhibitors by optimizing residual PDE2 activity in a series of PDE4 inhibitors, while simultaneously minimizing PDE4 activity. These newly designed PDE2 inhibitors bind to the PDE2 enzyme in a cGMP-like mode in co
Autor:
Skalitzky Donald James, Craig Banotai, Jayvardhan Pandit, Adam Ogden, James Hicks, Annise Paige Goodman, Xiao Kang Lu, Howard Miller, Howard Roark, Susan E. Bove, Sandra Lightle, Aurash B Shahripour, Timothy Braden, Mark S. Plummer, Katherine Welch, Charles J. Stankovic, Ron Sarver, Joseph A. Cornicelli, Christopher Whitehead, Brian Sanchez, Nalini Sadagopan, Heidi Baum, Richard Gowan, David Beidler, Xi Qiang Shen, Cindy Spessard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3443-3447
Selective phosphodiesterase 2 (PDE2) inhibitors are shown to have efficacy in a rat model of osteoarthritis (OA) pain. We identified potent, selective PDE2 inhibitors by optimizing residual PDE2 activity in a series of phosphodiesterase 4 (PDE4) inhi
Autor:
Lisa Mullins, Daniel P. Uccello, Justin I. Montgomery, Ye Che, John P. O'Donnell, Mark S. Plummer, Joseph A. Abramite, Seung Won Chung, Loren M. Price, Mark C. Noe, Laura A. McAllister, Rose Barham, Mark J. Mitton-Fry, Andrew P. Tomaras, Usa Reilly, Matthew Frank Brown, Jinshan M. Chen, Joseph Penzien, Carol A. Menard, Veerabahu Shanmugasundaram, Robert M. Oliver
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6832-6838
The synthesis and antibacterial activity of heterocyclic methylsulfone hydroxamates is presented. Compounds in this series are potent inhibitors of the LpxC enzyme, a key enzyme involved in the production of lipopolysaccharide (LPS) found in the oute
Autor:
Hongying Gao, Jennifer A. Young, Joel R. Hardink, Veerabahu Shanmugasundaram, Steven M. Finegan, David Pattavina, Joel T. Arcari, Jian Lin, Jianmin Sun, Mark J. Mitton-Fry, Thuy Hoang, Matthew Frank Brown, Hud Lawrence Risley, Rebecca Irvine, Mark Edward Flanagan, Brandon P. Schuff, Seungil Han, Manjinder S. Lall, Brian S. Gerstenberger, Mark Niosi, Thomas M. Harris, Michael D. Huband, Chao Li, Lisa Mullins, Sandra P. McCurdy, M. Megan Lemmon, John P. Mueller, Jennifer Winton, Jeffrey M. Casavant, Mark S. Plummer, Mark C. Noe, Joseph Penzien, Jeremy T. Starr, David M. George
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5989-5994
Novel siderophore-linked monobactams with in vitro and in vivo anti-microbial activity against MDR Gram-negative pathogens are described.
Publikováno v:
Organic Letters. 14:1386-1389
Tandem reaction sequences that selectively convert multiple C-H bonds of abundant hydrocarbon feedstocks to functionalized materials enable rapid buildup of molecular complexity in an economical way. A tandem C-H amination/vinylic C-H arylation react
Publikováno v:
Tetrahedron. 66:4816-4826
This report describes the use of Pd(II)/bis-sulfoxide 1 catalyzed intra- and intermolecular allylic C-H amination reactions to rapidly diversify structures containing a sensitive β-lactam core similar to that found in the monobactam antibiotic Aztre
Autor:
Anne Akin, Jacob Bradley Schwarz, Johnson Paul D, Peter G. Blazecka, Osuma Augustine Tobi, Derek Vrieze, Mark S. Plummer, Yun Huang, Ji Zhang, Michael Lovdahl, Norman L. Colbry, Brian Samas, Joseph Richard Bozelak, Timothy T. Curran, Andrew John Thorpe, Derek A. Pflum, Annise Paige Goodman, David C. Boyles, Garrett Hoge, Suzanne Ross Kesten
Publikováno v:
Tetrahedron Letters. 50:1167-1170
A chiral β-amino acid containing three contiguous chiral centers was synthesized efficiently in 11 steps, employing enantio-enriched β-ketoester as a key intermediate, via stereoselective catalytic hydrogenation of the corresponding enamide. Stereo
Autor:
John R. Rubin, Nigel Walker, Kenneth Dale Brady, Winnie W. Wong, Mark S. Plummer, Christine Humblet, Charles J. Stankovic, Aurash B Shahripour, Connolly Michael Kevin, Robert V. Talanian, Elizabeth A. Lunney, Hamish Allen, Tomi K. Sawyer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2779-2782
A series of compounds was designed and prepared as inhibitors of interleukin-1β converting enzyme (ICE), also known as caspase-1. These inhibitors, which employ a diphenyl ether sulfonamide, were designed to improve potency by forming favorable inte