Reducing Campylobacter jejuni colonization of poultry via vaccination.

Autor: Jason M Neal-McKinney, Derrick R Samuelson, Tyson P Eucker, Mark S Nissen, Rocio Crespo, Michael E Konkel

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114254 (2014)

Campylobacter jejuni is a leading bacterial cause of human gastrointestinal disease worldwide. While C. jejuni is a commensal organism in chickens, case-studies have demonstrated a link between infection with C. jejuni and the consumption of foods th

Externí odkaz: https://doaj.org/article/7447ed16d17f4006a07d5b70e7db5ebb

Molecular Mechanisms of Pharmaceutical Drug Binding into Calsequestrin

Autor: Kevin M. Lewis, Emiliano J. Sanchez, Hendrik Milting, Arun K Subra, ChulHee Kang, Ashwin K Muralidharan, Mark S. Nissen

Publikováno v: International Journal of Molecular Sciences, Vol 13, Iss 11, Pp 14326-14343 (2012)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 13; Issue 11; Pages: 14326-14343

Calsequestrin (CASQ) is a major Ca2+-storage/buffer protein present in the sarcoplasmic reticulum of both skeletal (CASQ1) and cardiac (CASQ2) muscles. CASQ has significant affinity for a number of pharmaceutical drugs with known muscular toxicities.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23569dace245ed608dbf20ba448cfd6
https://doi.org/10.3390/ijms131114326

Furfural reduction mechanism of a zinc-dependent alcohol dehydrogenase from Cupriavidus necator JMP134

Autor: Travis Hooper, Robert P. Hayes, Mark S. Nissen, ChulHee Kang, Qunrui Li, Luying Xun, Emiliano J. Sanchez, Brian N. Webb

Publikováno v: Molecular Microbiology. 83:85-95

Summary FurX is a tetrameric Zn-dependent alcohol dehydrogenase (ADH) from Cupriavidus necator JMP134. The enzyme rapidly reduces furfural with NADH as the reducing power. For the first time among characterized ADHs, the high-resolution structures of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c917fc5d165933fb352c822e477ae7de
https://doi.org/10.1111/j.1365-2958.2011.07914.x

1H and 13C NMR assignments and molecular modelling of a minor groove DNA-binding peptide from the HMG-I protein

Autor: Mark S. Nissen, Virginia F. Smith, Jaroslav Zajicek, Jeremy N.S. Evans, Gerhard R. Munske, Raymond Reeves

Publikováno v: International Journal of Peptide and Protein Research. 45:554-560

The HMG-I subfamily of high mobility group (HMG) chromatin proteins consists of DNA-binding proteins that preferentially bind to stretches of A·T-rich sequence both in vitro and in vivo. Recently, members of the HMG-I family have been suggested to b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249df2caaa5044125eb7cda43f8b08fb
https://doi.org/10.1111/j.1399-3011.1995.tb01319.x

Evidence for fast conformational change upon ligand dissociation in the HemAT class of bacterial oxygen sensors

Autor: James D. Satterlee, Audrey Mokdad, Randy W. Larsen, Mark S. Nissen

Publikováno v: FEBS Letters. 581:4512-4518

Here we report the results of transient absorption and photoacoustic calorimetry studies of CO photodissociation from the heme domain of the bacterial oxygen sensor HemAT-Bs. The results indicate that CO photolysis is accompanied by an overall DeltaH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5189fe208e38ba3096fd4b51759d644
https://doi.org/10.1016/j.febslet.2007.08.031