Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Mark S. Kirby"'
Autor:
John C. Kozlosky, Michael J. Graziano, Thomas Dorr, Joseph Horvath, Timothy P. Reilly, Raja Mangipudy, Laura Patrone, Mark S. Kirby, Victor Wang, Karyn Colman, Peter T. W. Cheng, Bradley A. Zinker, Mark Tirmenstein, Evan B. Janovitz
Publikováno v:
Toxicologic Pathology. 43:825-837
Glucokinase (GK) catalyzes the initial step in glycolysis and is a key regulator of glucose homeostasis. Therefore, glucokinase activators (GKa) have potential benefit in treating type 2 diabetes. Administration of a Bristol-Myers Squibb GKa (BMS-820
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7069173f03adfdd4e24921902362d3
https://doi.org/10.1177/0192623315581020
https://doi.org/10.1177/0192623315581020
Autor:
Ernst Niggli, Robert S Kieval, Andrea Doering, Dan H. Schulze, R. W. Hadley, Mark S. Kirby, Paulo Kofuji, W. J. Lederer
Publikováno v:
Schulze, Dan; Kofuji, Paulo; Hadley, Robert; Kirby, Mark S; Kieval, Robert S; Doering, Andrea; Niggli, Ernst; Lederer, W J (1993). Sodium/calcium exchanger in heart muscle: molecular biology, cellular function, and its special role in excitation-contraction coupling. Cardiovascular research, 27(10), pp. 1726-1734. Oxford University Press 10.1093/cvr/27.10.1726
Scopus-Elsevier
Europe PubMed Central
Scopus-Elsevier
Europe PubMed Central
The Na/Ca exchanger has been examined with respect to its molecular biology, its cellular function, and its role in excitation-contraction coupling. The Na/Ca exchanger plays a central part in excitation-contraction coupling, setting the level of sar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee23d8831f9f271452d42b7f3846a070
http://doc.rero.ch/record/290877/files/27-10-1726.pdf
http://doc.rero.ch/record/290877/files/27-10-1726.pdf
Autor:
Steven J. Walker, Vidyhashankar Ramamurthy, Jun Li, Shung Wu, David K. Leahy, John D. Dimarco, Brad D. Maxwell, Daniel M. Camac, Joseph R. Taylor, Akbar Nayeem, Zhiwei Guo, James J. Li, Xiang-Yang Ye, Frederick Moulin, Paul E. Morin, Stepen P O’Connor, Haixia Wang, Jeffrey A. Robl, Rachel Zebo, Mark S. Kirby, Thomas Harrity, Joel C. Barrish, Timothy W. Harper, Lawrence L Kennedy, Rajasree Golla, Atsu Apedo, Bogdan Sleczka, Yi-Xin Li, David S. Yoon, Bin He, Steven Sheriff, Ramakrishna Seethala, Nathan Morgan, Mengmeng Wang, Randolph P. Ponticiello, Raymond P. Scaringe, Stephanie Y. Chen, Jianqing Li, Zhenqiu Hong, Ronald L. Hanson, David A. Gordon
Publikováno v:
Journal of medicinal chemistry. 60(12)
BMS-816336 (6n-2), a hydroxy-substituted adamantyl acetamide, has been identified as a novel, potent inhibitor against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme (IC50 3.0 nM) with >10000-fold selectivity over human 11β-hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86602b708c78e42f5648acb482b306b
https://pubmed.ncbi.nlm.nih.gov/28537398
https://pubmed.ncbi.nlm.nih.gov/28537398
Autor:
Gregory N. Cosma, William E. Achanzar, Jiangyue Wu, Lauro Minimo, Carolyn F. Moyer, Mark S. Kirby, Mark D. Gorrell, Nicole D. Ordway, Laura Rosini-Marthaler, Russell Gullo, Kristina D. Chadwick, Eric. B. Harstad, Jonathan S. Rosenblum
Publikováno v:
Regulatory Peptides. 186:26-35
Dipeptidyl peptidases (DPPs) are proteolytic enzymes that regulate many physiological systems by degrading signaling peptides. DPP8 and DPP9 are distinct from DPP4 in sequence, cellular localization and expression levels, thus implying distinct funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4878f63ec0bafff49518c692285bc06a
https://doi.org/10.1016/j.regpep.2013.07.003
https://doi.org/10.1016/j.regpep.2013.07.003
Autor:
Margarete Mehrabian, Simon T. Hui, Brian J. Bennett, Elizabeth Nam, Mark S. Kirby, Todd G. Kirchgessner, Aiqing He, Lawrence W. Castellani, Thomas A. Drake, Calvin Pan, Christoph Rau, Brian W. Parks, Luke K. Ursell, Peter S. Gargalovic, Aldons J. Lusis, Elin Org, Bradley A. Zinker, Emrah Kostem, Eleazar Eskin, Christian A. Drevon, Rob Knight, Frode Norheim, Mete Civelek
Publikováno v:
Cell Metabolism. 17:141-152
SummaryObesity is a highly heritable disease driven by complex interactions between genetic and environmental factors. Human genome-wide association studies (GWAS) have identified a number of loci contributing to obesity; however, a major limitation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82704037307d6fdba4748ab8f7f124d
https://doi.org/10.1016/j.cmet.2012.12.007
https://doi.org/10.1016/j.cmet.2012.12.007
Autor:
Hong Su, Mark S. Kirby, Huidong Gu, Lisa J. Christopher, Mark E. Arnold, David W. Boulton, Laura Cojocaru, Bruce Stouffer, William G. Humphreys, Xiaohui Xu, Roger Demers
Publikováno v:
Journal of Chromatography B. :77-86
A liquid chromatography and tandem mass spectrometry (LC-MS/MS) method was developed and validated to simultaneously determine the concentrations of saxagliptin (Onglyza™, BMS-477118) and its major active metabolite, 5-hydroxy saxagliptin to suppor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce731b5c1cea929816e93936812ecdc0
https://doi.org/10.1016/j.jchromb.2012.01.033
https://doi.org/10.1016/j.jchromb.2012.01.033
Autor:
Mengmeng Wang, Akbar Nayeem, Ramakrishna Seethala, Stephanie Y. Chen, Rajasree Golla, Jeffrey A. Robl, Bin He, Yi-Xin Li, Bogdan Sleczka, David A. Gordon, Xiang-Yang Ye, Timothy W. Harper, Mark S. Kirby
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6699-6704
Starting from high throughput screening hit 2-adamantyl acetic acid 3, a series of polycyclic acids have been designed and synthesized as novel, potent, and selective inhibitors of human 11β-HSD-1. Structure-activity relationships of two different r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722d41a1003cb116de1e23e259a551b2
https://doi.org/10.1016/j.bmcl.2011.09.055
https://doi.org/10.1016/j.bmcl.2011.09.055
Autor:
Yaqun Zhang, Dianlin Xie, Kevin Kish, Aiying Wang, Stephen P. O'connor, Wei Meng, Herbert E. Klei, Huji Turdi, Lawrence G. Hamann, Robert Zahler, Jovita Marcinkeviciene, Robert Paul Brigance, Thomas Harrity, James K. Tamura, Aberra Fura, Carolyn A. Weigelt, Chao Hannguang J, Mark S. Kirby
Publikováno v:
Journal of Medicinal Chemistry. 53:5620-5628
Continued structure-activity relationship (SAR) exploration within our previously disclosed azolopyrimidine containing dipeptidyl peptidase-4 (DPP4) inhibitors led us to focus on an imidazolopyrimidine series in particular. Further study revealed tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ca7c24a1f6700c83b6ed4ef874c797
https://doi.org/10.1021/jm100634a
https://doi.org/10.1021/jm100634a
Autor:
David P. Rotella, Robert Zahler, David J. Augeri, Timur Gungor, Aiying Wang, William S. Slusarchyk, Scott A. Bolton, James C. Sutton, Jeffrey A. Robl, Zulan Pi, Karnail S. Atwal, Ligaya M. Simpkins, Yajun Liu, Chet Kwon, Lawrence G. Hamann, Rex A. Parker, Guohua Zhao, Mark S. Kirby, Zhong Sun, David R. Magnin, Jovita Marcinkeviciene, James G. Robertson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6476-6480
The synthesis and structure–activity relationships of novel dipeptidyl peptidase IV inhibitors replacing the classical cyanopyrrolidine P1 group with other small nitrogen heterocycles are described. A unique potency enhancement was achieved with β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc358df323e8065d6c640de03adf2c4
https://doi.org/10.1016/j.bmcl.2007.09.090
https://doi.org/10.1016/j.bmcl.2007.09.090
Autor:
Prakash Taunk, Aiying Wang, Jovita Marcinkeviciene, David R. Magnin, Mark S. Kirby, Lawrence G. Hamann, James G. Robertson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1731-1734
A series of seco-prolinenitrile-containing dipeptides were synthesized and assayed as inhibitors of the N-terminal sequence-specific serine protease dipeptidyl peptidase IV, a promising new target for treatment of type 2 diabetes. The inhibitors desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8680c16a3b86af556cf24eab3052cba7
https://doi.org/10.1016/j.bmcl.2005.11.098
https://doi.org/10.1016/j.bmcl.2005.11.098