Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Mark S. Hipp"'
Autor:
Franziska Köper, Danara Vonk, Malte W. Dirksen, Isabel Gross, Axel Heep, Torsten Plösch, Mark S. Hipp, Anja U. Bräuer
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Plasticity-related gene (PRG) 5 is a vertebrate specific membrane protein, that belongs to the family of lipid-phosphate phosphatases (LPPs). It is prominently expressed in neurons and is involved in cellular processes such as growth-cone guidance an
Externí odkaz:
https://doaj.org/article/d40b287b76ed4696a98d976693336a00
Autor:
Itika Saha, Patricia Yuste-Checa, Miguel Da Silva Padilha, Qiang Guo, Roman Körner, Hauke Holthusen, Victoria A. Trinkaus, Irina Dudanova, Rubén Fernández-Busnadiego, Wolfgang Baumeister, David W. Sanders, Saurabh Gautam, Marc I. Diamond, F. Ulrich Hartl, Mark S. Hipp
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Tau aggregates are associated with several neurodegenerative disorders. In this work, I. Saha and colleagues show that valosin-containing protein (VCP) recruited to Tau fibrils disaggregates them. However, this process comes at a cost: it generates s
Externí odkaz:
https://doaj.org/article/55b4a135031e4d249c4f455de3857bf8
Autor:
Patricia Yuste-Checa, Victoria A. Trinkaus, Irene Riera-Tur, Rahmi Imamoglu, Theresa F. Schaller, Huping Wang, Irina Dudanova, Mark S. Hipp, Andreas Bracher, F. Ulrich Hartl
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Variants of the extracellular chaperone Clusterin are associated with Alzheimer’s disease (AD) and Clusterin levels are elevated in AD patient brains. Here, the authors show that Clusterin binds to oligomeric Tau, which enhances the seeding capacit
Externí odkaz:
https://doaj.org/article/6817e37ab6504c1fa561f4ad2a667e95
Autor:
Victoria A. Trinkaus, Irene Riera-Tur, Antonio Martínez-Sánchez, Felix J. B. Bäuerlein, Qiang Guo, Thomas Arzberger, Wolfgang Baumeister, Irina Dudanova, Mark S. Hipp, F. Ulrich Hartl, Rubén Fernández-Busnadiego
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. Here, authors use cryo-electron tomography to image neuronal α-Syn inclusions in situ and find that inclusions con
Externí odkaz:
https://doaj.org/article/84faa4c08a42424bb5304d04db2b7ff0
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Identifying factors that enable cells to induce a potent stress response to amyloid-like aggregation can provide further insight into the mechanism of stress regulation. Here, the authors express polyglutamine-expanded Huntingtin as a model disease p
Externí odkaz:
https://doaj.org/article/bf06109c704f419bbd81a8c23509df78
Autor:
Isabel Gross, Nicola Brandt, Danara Vonk, Franziska Köper, Lars Wöhlbrand, Ralf Rabus, Martin Witt, Axel Heep, Torsten Plösch, Mark S. Hipp, Anja U. Bräuer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
During adult neurogenesis, neuronal stem cells differentiate into mature neurons that are functionally integrated into the existing network. One hallmark during the late phase of this neurodifferentiation process is the formation of dendritic spines.
Externí odkaz:
https://doaj.org/article/bc340cad538f4d87bae896fb81e63a42
Autor:
Fabian Hosp, Sara Gutiérrez-Ángel, Martin H. Schaefer, Jürgen Cox, Felix Meissner, Mark S. Hipp, F.-Ulrich Hartl, Rüdiger Klein, Irina Dudanova, Matthias Mann
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2291-2303 (2017)
Aggregation of polyglutamine-expanded huntingtin exon 1 (HttEx1) in Huntington’s disease (HD) proceeds from soluble oligomers to late-stage inclusions. The nature of the aggregates and how they lead to neuronal dysfunction is not well understood. W
Externí odkaz:
https://doaj.org/article/6eb49d931f08402aa04d09c42c8ca559
Publikováno v:
eLife, Vol 10 (2021)
The most frequent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia is a G4C2 repeat expansion in the C9orf72 gene. This expansion gives rise to translation of aggregating dipeptide repeat (DPR) proteins, including poly-GA as
Externí odkaz:
https://doaj.org/article/b2c40997a5ee4b7ab60a50d8173ca2dd
Publikováno v:
Mauthe, M, Kampinga, H H, Hipp, M S & Reggiori, F 2023, ' Digest it all : the lysosomal turnover of cytoplasmic aggregates ', Trends in Biochemical Sciences, vol. 48, no. 3, pp. 216-228 . https://doi.org/10.1016/j.tibs.2022.09.012
Aggrephagy describes the selective lysosomal transport and turnover of cytoplasmic protein aggregates by macro-autophagy. In this process, protein aggregates and conglomerates are polyubiquitinated and then sequestered by autophagosomes. Soluble sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10c7d46ef3bd3e7b0bc5006b372d955
https://hdl.handle.net/11370/9caebdc8-3f8b-422a-b076-8cfd9ff4630d
https://hdl.handle.net/11370/9caebdc8-3f8b-422a-b076-8cfd9ff4630d
Autor:
Henrick Riemenschneider, Qiang Guo, Jakob Bader, Frédéric Frottin, Daniel Farny, Gernot Kleinberger, Christian Haass, Matthias Mann, F. Ulrich Hartl, Wolfgang Baumeister, Mark S Hipp, Felix Meissner, Rubén Fernández‐Busnadiego, Dieter Edbauer
Publikováno v:
Embo Reports, 23(6):e53890. Wiley
EMBO reports 23(6), e53890 (2022). doi:10.15252/embr.202153890
EMBO Reports
EMBO Reports, 2022, 23, ⟨10.15252/embr.202153890⟩
EMBO reports 23(6), e53890 (2022). doi:10.15252/embr.202153890
EMBO Reports
EMBO Reports, 2022, 23, ⟨10.15252/embr.202153890⟩
International audience; Aggregation of the multifunctional RNA-binding protein TDP-43 defines large subgroups of amyotrophic lateral sclerosis and frontotemporal dementia and correlates with neurodegeneration in both diseases. In disease, characteris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f47f8b65554198f2de3cc8266a570e
https://research.rug.nl/en/publications/0af60e3e-49be-447c-9742-e5a5283a2b78
https://research.rug.nl/en/publications/0af60e3e-49be-447c-9742-e5a5283a2b78
