Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Mark S. Filla"'
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
Primary open angle glaucoma (POAG) is a progressive and chronic disease exhibiting many of the features of fibrosis. The extracellular matrix (ECM) in the trabecular meshwork (TM) undergoes extensive remodeling and enhanced rigidity, resembling fibro
Externí odkaz:
https://doaj.org/article/e5a0561576c84512a19c70359bf8e918
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Integrins are a family of heterodimeric receptors composed of an α- and β-subunit that mediate cell-adhesion to a number of extracellular matrix (ECM) proteins in the Trabecular Meshwork/Schlemm’s canal (TM/SC) of the eye. Upon binding an ECM lig
Externí odkaz:
https://doaj.org/article/b1bce309f6b94fa68ee9f34b8cf280dd
Publikováno v:
Cells, Vol 12, Iss 3, p 504 (2023)
Although elevated TGFβ2 levels appear to be a causative factor in glaucoma pathogenesis, little is known about how TGFβ2 expression is regulated in the trabecular meshwork (TM). Here, we investigated if activation of the cytokine regulator NFATc1 c
Externí odkaz:
https://doaj.org/article/41d56406c9ce4999bd255fd8657921f7
Autor:
Jennifer A. Faralli, Harini Desikan, Jennifer Peotter, Nitin Kanneganti, Benjamin Weinhaus, Mark S. Filla, Donna M. Peters
Publikováno v:
Molecular Vision, Vol 25, Iss 1, Pp 237-254 (2019)
Purpose: The purpose of this study is to examine the expression profile of genes related to integrin-mediated phagocytosis that are altered by dexamethasone (DEX) and/or αvβ3 integrin signaling to gain a better understanding of the molecular basis
Externí odkaz:
https://doaj.org/article/fdcc00f626fc4c24860bf77abc29ff89
Publikováno v:
Cells, Vol 10, Iss 8, p 1923 (2021)
Studies from our laboratory have suggested that activation of αvβ3 integrin-mediated signaling could contribute to the fibrotic-like changes observed in primary open angle glaucoma (POAG) and glucocorticoid-induced glaucoma. To determine how αvβ3
Externí odkaz:
https://doaj.org/article/d34ae09261224e6087659d8ff8c925bd
Autor:
Jennifer A. Faralli, Harini Desikan, Donna M. Peters, Jennifer L. Peotter, Mark S. Filla, Abigail C. Wannow
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Fibronectin fibrillogenesis is an integrin-mediated process that may contribute to the pathogenesis of primary open-angle glaucoma (POAG). Here, we examined the effects of αvβ3 integrins on fibrillogenesis in immortalized TM-1 cells and hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240abce67a888f857a64ac161b2ea0dd
http://europepmc.org/articles/PMC6750892
http://europepmc.org/articles/PMC6750892
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0237932 (2020)
PLoS ONE, Vol 15, Iss 8, p e0237932 (2020)
Increased deposition of fibronectin fibrils containing EDA+fibronectin by TGFβ2 is thought to be involved in the reduction of aqueous humor outflow across the trabecular meshwork (TM) of the eye and the elevation in intraocular pressure (IOP) observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cb4690bae42176ad7920c456af8ffc
http://europepmc.org/articles/PMC7444551
http://europepmc.org/articles/PMC7444551
Publikováno v:
Cells
Cells, Vol 10, Iss 1923, p 1923 (2021)
Volume 10
Issue 8
Cells, Vol 10, Iss 1923, p 1923 (2021)
Volume 10
Issue 8
Studies from our laboratory have suggested that activation of αvβ3 integrin-mediated signaling could contribute to the fibrotic-like changes observed in primary open angle glaucoma (POAG) and glucocorticoid-induced glaucoma. To determine how αvβ3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf2db7aa3ef8371e595eed2946b0402
https://doi.org/10.3390/cells10081923
https://doi.org/10.3390/cells10081923
Publikováno v:
Experimental Eye Research. 158:124-136
Integrins are a family of heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix (ECM). In addition to their role as adhesion receptors, integrins can act as ''bidirectional signal transducers'' that coordinate a larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744596abaa1bfec76be208d044ab9fdd
https://doi.org/10.1016/j.exer.2016.05.011
https://doi.org/10.1016/j.exer.2016.05.011
Publikováno v:
Cells
Primary open angle glaucoma (POAG) is the most common form of glaucoma and the 2nd most common cause of irreversible vision loss in the United States. Nearly 67 million people have the disease worldwide including >3 million in the United States. A ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c355ba54dafb2ec5307be3d2641a80
http://europepmc.org/articles/PMC6953041
http://europepmc.org/articles/PMC6953041