Translational Control of the SigR-Directed Oxidative Stress Response in Streptomyces via IF3-Mediated Repression of a Noncanonical GTC Start Codon

Autor: Morgan A. Feeney, Govind Chandra, Kim C. Findlay, Mark S. B. Paget, Mark J. Buttner

Publikováno v: mBio, Vol 8, Iss 3 (2017)

ABSTRACT The major oxidative stress response in Streptomyces is controlled by the sigma factor SigR and its cognate antisigma factor RsrA, and SigR activity is tightly controlled through multiple mechanisms at both the transcriptional and posttransla

Externí odkaz: https://doaj.org/article/b498b2ea2384475489dd613133b4c885

A non-canonical mismatch repair pathway in prokaryotes

Autor: Jerónimo Rodríguez-Beltrán, Simon J. Waddell, Przemysław Płociński, Alfredo Castañeda-García, Coloma Costas, Mark S. B. Paget, Aidan J. Doherty, N. Alonso, Ana Isabel Prieto, Laura Pérez-Lago, Ana M. Rojas, Jesús Blázquez, Michel Herranz, Tone Tønjum, D. García de Viedma, Daire Cantillon, Ephrem Debebe Zegeye

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname

Castañeda-García, Alfredo et al.
Mismatch repair (MMR) is a near ubiquitous pathway, essential for the maintenance of genome stability. Members of the MutS and MutL protein families perform key steps in mismatch correction. Despite the major i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae75535a031265967f7754166ab3e2e
https://hdl.handle.net/20.500.12530/32826

Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA

Autor: Paul Dominic B. Olinares, Joshua E. Flack, Elizabeth A. Hubin, Aline Tabib-Salazar, Laurence J. Humphrey, Seth A. Darst, Elizabeth A. Campbell, Mark S. B. Paget

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 112(23)

Gene expression is highly regulated at the step of transcription initiation, and transcription activators play a critical role in this process. RbpA, an actinobacterial transcription activator that is essential in Mycobacterium tuberculosis (Mtb), bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a56a08a21c4f96d65f1af54c93488e
https://pubmed.ncbi.nlm.nih.gov/26040003

Thiol-Based Regulatory Switches

Autor: Mark J. Buttner, Mark S. B. Paget

Publikováno v: Annual Review of Genetics. 37:91-121

▪ Abstract Thiol-based regulatory switches play central roles in cellular responses to oxidative stress, nitrosative stress, and changes in the overall thiol-disulfide redox balance. Protein sulfhydryls offer a great deal of flexibility in the diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0a63948bf61773d00a60b9467ffbc2
https://doi.org/10.1146/annurev.genet.37.110801.142538

Identification and Structure of the Anti-sigma Factor-binding Domain of the Disulphide-stress Regulated Sigma Factor σR from Streptomyces coelicolor

Autor: Mark J. Buttner, David M. Lawson, Mark S. B. Paget, Piotr Jakimowicz, Colin Kleanthous, Clare E. M. Stevenson, Wei Li, Nicolas Burton

Publikováno v: Journal of Molecular Biology. 323:225-236

The extracytoplasmic function (ECF) sigma factor sigma(R) is a global regulator of redox homeostasis in the antibiotic-producing bacterium Streptomyces coelicolor, with a similar role in other actinomycetes such as Mycobacterium tuberculosis. Normall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d3725a589da86ea8d3ef229abb6a69
https://doi.org/10.1016/s0022-2836(02)00948-8