Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Mark S Wilson"'
Autor:
Yashaswini Kannan, Lewis J Entwistle, Victoria S Pelly, Jimena Perez-Lloret, Alan W Walker, Steven C Ley, Mark S Wilson
Publikováno v:
PLoS Pathogens, Vol 13, Iss 7, p e1006536 (2017)
TPL-2 (COT, MAP3K8) kinase activates the MEK1/2-ERK1/2 MAPK signaling pathway in innate immune responses following TLR, TNFR1 and IL-1R stimulation. TPL-2 contributes to type-1/Th17-mediated autoimmunity and control of intracellular pathogens. We rec
Externí odkaz:
https://doaj.org/article/f642179410e741b1a6bfc7545795a5e5
Autor:
Yashaswini Kannan, Jimena Perez-Lloret, Yanda Li, Lewis J Entwistle, Hania Khoury, Stamatia Papoutsopoulou, Radma Mahmood, Nuha R Mansour, Stanley Ching-Cheng Huang, Edward J Pearce, Luiz Pedro S de Carvalho, Steven C Ley, Mark S Wilson
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005783 (2016)
Persistent TH2 cytokine responses following chronic helminth infections can often lead to the development of tissue pathology and fibrotic scarring. Despite a good understanding of the cellular mechanisms involved in fibrogenesis, there are very few
Externí odkaz:
https://doaj.org/article/9e27add65ae847c1a7c1fa12789084b2
Autor:
Stephanie M Coomes, Victoria S Pelly, Yashaswini Kannan, Isobel S Okoye, Stephanie Czieso, Lewis J Entwistle, Jimena Perez-Lloret, Nikolay Nikolov, Alexandre J Potocnik, Judit Biró, Jean Langhorne, Mark S Wilson
Publikováno v:
PLoS Pathogens, Vol 11, Iss 7, p e1004994 (2015)
Parasitic helminths establish chronic infections in mammalian hosts. Helminth/Plasmodium co-infections occur frequently in endemic areas. However, it is unclear whether Plasmodium infections compromise anti-helminth immunity, contributing to the chro
Externí odkaz:
https://doaj.org/article/91399783e528489ca91774440c8d3a5e
Autor:
Samir Kelada, Praveen Sethupathy, Isobel S Okoye, Eleni Kistasis, Stephanie Czieso, Sandra D White, David Chou, Craig Martens, Stacy M Ricklefs, Kimmo Virtaneva, Dan E Sturdevant, Stephen F Porcella, Yasmine Belkaid, Thomas A Wynn, Mark S Wilson
Publikováno v:
PLoS Pathogens, Vol 9, Iss 6, p e1003451 (2013)
A diverse suite of effector immune responses provide protection against various pathogens. However, the array of effector responses must be immunologically regulated to limit pathogen- and immune-associated damage. CD4(+)Foxp3(+) regulatory T cells (
Externí odkaz:
https://doaj.org/article/965be58dbc95495d8f4274ea20588e05
Autor:
Luke Barron, Amber M Smith, Karim C El Kasmi, Joseph E Qualls, Xiaozhu Huang, Allen Cheever, Lee A Borthwick, Mark S Wilson, Peter J Murray, Thomas A Wynn
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61961 (2013)
Th2-driven lung inflammation increases Arginase 1 (Arg1) expression in alternatively-activated macrophages (AAMs). AAMs modulate T cell and wound healing responses and Arg1 might contribute to asthma pathogenesis by inhibiting nitric oxide production
Externí odkaz:
https://doaj.org/article/3070d76f60e94c6381d4c5f639a7299c
Publikováno v:
PLoS Pathogens, Vol 7, Iss 8, p e1002171 (2011)
Despite effective chemotherapy to treat schistosome infections, re-infection rates are extremely high. Resistance to reinfection can develop, however it typically takes several years following numerous rounds of treatment and re-infection, and often
Externí odkaz:
https://doaj.org/article/9053d5f2037340eaa4ba0f256bb8350e
Autor:
John T Pesce, Thirumalai R Ramalingam, Margaret M Mentink-Kane, Mark S Wilson, Karim C El Kasmi, Amber M Smith, Robert W Thompson, Allen W Cheever, Peter J Murray, Thomas A Wynn
Publikováno v:
PLoS Pathogens, Vol 5, Iss 4, p e1000371 (2009)
Macrophage-specific expression of Arginase-1 is commonly believed to promote inflammation, fibrosis, and wound healing by enhancing L-proline, polyamine, and Th2 cytokine production. Here, however, we show that macrophage-specific Arg1 functions as a
Externí odkaz:
https://doaj.org/article/9f58dce111ec448b822c1fe1f4d33651
Autor:
John T Pesce, Thirumalai R Ramalingam, Mark S Wilson, Margaret M Mentink-Kane, Robert W Thompson, Allen W Cheever, Joseph F Urban, Thomas A Wynn
Publikováno v:
PLoS Pathogens, Vol 5, Iss 4, p e1000393 (2009)
Retnla (Resistin-like molecule alpha/FIZZ1) is induced during Th2 cytokine immune responses. However, the role of Retnla in Th2-type immunity is unknown. Here, using Retnla(-/-) mice and three distinct helminth models, we show that Retnla functions a
Externí odkaz:
https://doaj.org/article/2421bca13ec8421da25ecd9eb184c829
Autor:
Robert W Thompson, John T Pesce, Thirumalai Ramalingam, Mark S Wilson, Sandy White, Allen W Cheever, Stacy M Ricklefs, Stephen F Porcella, Lili Li, Lesley G Ellies, Thomas A Wynn
Publikováno v:
PLoS Pathogens, Vol 4, Iss 3, p e1000023 (2008)
Cationic amino acid transporters (CAT) are important regulators of NOS2 and ARG1 activity because they regulate L-arginine availability. However, their role in the development of Th1/Th2 effector functions following infection has not been investigate
Externí odkaz:
https://doaj.org/article/c2010fd7023f4d37807348b4daa87aa2
Autor:
Kevin N Couper, Daniel G Blount, Mark S Wilson, Julius C Hafalla, Yasmine Belkaid, Masahito Kamanaka, Richard A Flavell, J Brian de Souza, Eleanor M Riley
Publikováno v:
PLoS Pathogens, Vol 4, Iss 2, p e1000004 (2008)
The outcome of malaria infection is determined, in part, by the balance of pro-inflammatory and regulatory immune responses. Failure to develop an effective pro-inflammatory response can lead to unrestricted parasite replication, whilst failure to re
Externí odkaz:
https://doaj.org/article/d66317bec92f42efb8eb317ae9413b91