Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Mark S Pearson"'
Autor:
Gebeyaw G Mekonnen, Bemnet A Tedla, Mark S Pearson, Luke Becker, Matt Field, Abena S Amoah, Govert van Dam, Paul L A M Corstjens, Takafira Mduluza, Francisca Mutapi, Alex Loukas, Javier Sotillo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 1, p e0010151 (2022)
Schistosoma haematobium is the leading cause of urogenital schistosomiasis and it is recognised as a class 1 carcinogen due to the robust association of infection with bladder cancer. In schistosomes, tetraspanins (TSPs) are abundantly present in dif
Externí odkaz:
https://doaj.org/article/83102718f43f43a0bc90839bc6fc9b30
Autor:
Mark S Pearson, PhD, Bemnet A Tedla, PhD, Gebeyaw G Mekonnen, PhD, Carla Proietti, PhD, Luke Becker, BSc, Rie Nakajima, MSc, Al Jasinskas, PhD, Denise L Doolan, PhD, Abena S Amoah, PhD, Stefanie Knopp, PhD, David Rollinson, PhD, Said M Ali, MSc, Fatma Kabole, MD, Cornelis H Hokke, PhD, Akim A Adegnika, MD, Matt A Field, PhD, Govert van Dam, PhD, Paul L A M Corstjens, PhD, Takafira Mduluza, PhD, Francisca Mutapi, PhD, Claude Oeuvray, PhD, Beatrice Greco, PhD, Sujittra Chaiyadet, PhD, Thewarach Laha, PhD, Pengfei Cai, PhD, Donald P McManus, PhD, Maria Elena Bottazzi, PhD, Philip L Felgner, PhD, Javier Sotillo, PhD, Alex Loukas, PhD
Publikováno v:
The Lancet Microbe, Vol 2, Iss 11, Pp e617-e626 (2021)
Summary: Background: Sensitive diagnostics are needed for effective management and surveillance of schistosomiasis so that current transmission interruption goals set by WHO can be achieved. We aimed to screen the Schistosoma haematobium secretome to
Externí odkaz:
https://doaj.org/article/e9c0510583ca4bf58360b82613221a36
Autor:
Jayden Logan, Mark S Pearson, Srikanth S Manda, Young-Jun Choi, Matthew Field, Ramon M Eichenberger, Jason Mulvenna, Shivashankar H Nagaraj, Ricardo T Fujiwara, Pedro Gazzinelli-Guimaraes, Lilian Bueno, Vitor Mati, Jeffrey M Bethony, Makedonka Mitreva, Javier Sotillo, Alex Loukas
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0008237 (2020)
The human hookworm Necator americanus infects more than 400 million people worldwide, contributing substantially to the poverty in these regions. Adult stage N. americanus live in the small intestine of the human host where they inject excretory/secr
Externí odkaz:
https://doaj.org/article/4babd1df41ee4fd4a04ad9e342026748
Autor:
Bemnet A Tedla, Javier Sotillo, Darren Pickering, Ramon M Eichenberger, Stephanie Ryan, Luke Becker, Alex Loukas, Mark S Pearson
Publikováno v:
PLoS Pathogens, Vol 15, Iss 12, p e1008213 (2019)
Cholinesterase (ChE) function in schistosomes is essential for orchestration of parasite neurotransmission but has been poorly defined with respect to the molecules responsible. Interrogation of the S. mansoni genome has revealed the presence of thre
Externí odkaz:
https://doaj.org/article/cf9fbff96c8344b6a5232396b5fba0cd
Autor:
Javier Sotillo, Mark S Pearson, Luke Becker, Gebeyaw G Mekonnen, Abena S Amoah, Govert van Dam, Paul L A M Corstjens, Janice Murray, Takafira Mduluza, Francisca Mutapi, Alex Loukas
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007362 (2019)
BackgroundSchistosomiasis is a neglected disease affecting hundreds of millions worldwide. Of the three main species affecting humans, Schistosoma haematobium is the most common, and is the leading cause of urogenital schistosomiasis. S. haematobium
Externí odkaz:
https://doaj.org/article/a19f474dc61e4ecb819f8f24a7aa8891
Autor:
George R Wendt, Julie NR Collins, Jimin Pei, Mark S Pearson, Hayley M Bennett, Alex Loukas, Matthew Berriman, Nick V Grishin, James J Collins III
Publikováno v:
eLife, Vol 7 (2018)
Schistosomes infect more than 200 million people. These parasitic flatworms rely on a syncytial outer coat called the tegument to survive within the vasculature of their host. Although the tegument is pivotal for their survival, little is known about
Externí odkaz:
https://doaj.org/article/2c4c49c67e644a15a5a526a95e9a8ecd
Autor:
Madhu K Sundaraneedi, Bemnet A Tedla, Ramon M Eichenberger, Luke Becker, Darren Pickering, Michael J Smout, Siji Rajan, Phurpa Wangchuk, F Richard Keene, Alex Loukas, J Grant Collins, Mark S Pearson
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 12, p e0006134 (2017)
Schistosomiasis affects over 200 million people and there are concerns whether the current chemotherapeutic control strategy (periodic mass drug administration with praziquantel (PZQ)-the only licenced anti-schistosome compound) is sustainable, neces
Externí odkaz:
https://doaj.org/article/092fa447a02a4f12a7290df14a2f9ef0
Autor:
Phurpa Wangchuk, Mark S Pearson, Paul R Giacomin, Luke Becker, Javier Sotillo, Darren Pickering, Michael J Smout, Alex Loukas
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004908 (2016)
BACKGROUND:Whipworms and blood flukes combined infect almost one billion people in developing countries. Only a handful of anthelmintic drugs are currently available to treat these infections effectively; there is therefore an urgent need for new gen
Externí odkaz:
https://doaj.org/article/69b2291892544b7e94fa458951c9fdf3
Autor:
Mark S Pearson, Alex Loukas
Publikováno v:
eLife, Vol 5 (2016)
A population of stems cells continuously rejuvenates the outer surface of a human parasitic flatworm.
Externí odkaz:
https://doaj.org/article/8088e0821dfc4a91ba1f922b93bfe7b4
Autor:
Soraya Gaze, Patrick Driguez, Mark S Pearson, Tiago Mendes, Denise L Doolan, Angela Trieu, Donald P McManus, Geoffrey N Gobert, Maria Victoria Periago, Rodrigo Correa Oliveira, Fernanda C Cardoso, Guilherme Oliveira, Rie Nakajima, Al Jasinskas, Chris Hung, Li Liang, Jozelyn Pablo, Jeffrey M Bethony, Philip L Felgner, Alex Loukas
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1004033 (2014)
Schistosomiasis is a neglected tropical disease that is responsible for almost 300,000 deaths annually. Mass drug administration (MDA) is used worldwide for the control of schistosomiasis, but chemotherapy fails to prevent reinfection with schistosom
Externí odkaz:
https://doaj.org/article/ae73e03bc4144d068e71898b26df6950