Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mark S Padolina"'
Autor:
Ying Lai, Jiajie Diao, Daniel J Cipriano, Yunxiang Zhang, Richard A Pfuetzner, Mark S Padolina, Axel T Brunger
Publikováno v:
eLife, Vol 3 (2014)
Previously we showed that fast Ca2+-triggered vesicle fusion with reconstituted neuronal SNAREs and synaptotagmin-1 begins from an initial hemifusion-free membrane point contact, rather than a hemifusion diaphragm, using a single vesicle–vesicle li
Externí odkaz:
https://doaj.org/article/8f0e2952d6a54f16a7698ee6aae9f16e
Autor:
Robert P. Sparks, Mark S. Padolina, Gregory E. Miner, Logan R. Hurst, Rutilio A. Fratti, Matthew L. Starr
Publikováno v:
Journal of Biological Chemistry. 291:17651-17663
The yeast vacuole requires four SNAREs to trigger membrane fusion including the soluble Qc-SNARE Vam7. The N-terminal PX domain of Vam7 binds to the lipid phosphatidylinositol 3-phosphate (PI3P) and the tethering complex HOPS (homotypic fusion and va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580e0add86165283199dac52d84709fa
https://doi.org/10.1074/jbc.m116.725366
https://doi.org/10.1074/jbc.m116.725366
Autor:
Jiajie Diao, Sandro Vivona, Axel T. Brunger, Ucheor B. Choi, Richard A. Pfuetzner, Ying Lai, William I. Weis, Niket Shah, Yunxiang Zhang, Karen N. Colbert, Mark S. Padolina, Susanne Ressl, Daniel J. Cipriano
Publikováno v:
The Journal of Biological Chemistry
Background: Munc18-1 is an important factor for synaptic transmitter release, but its molecular mechanism remains an enigma. Results: Munc18a does not affect fusion kinetics. It can sequester syntaxin-1A molecules from the syntaxin-1A·SNAP-25 t-SNAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67af1ff3a36df15c63f71012dde29123
https://doi.org/10.1074/jbc.m114.630772
https://doi.org/10.1074/jbc.m114.630772
Complexin-1 Enhances the On-Rate of Vesicle Docking via Simultaneous SNARE and Membrane Interactions
Autor:
Yunxiang Zhang, Axel T. Brunger, Mark S. Padolina, Daniel J. Cipriano, Jiajie Diao, Sachi Shah, Minglei Zhao, Richard A. Pfuetzner
Publikováno v:
Journal of the American Chemical Society
In synaptic terminals, complexin is thought to have inhibitory and activating roles for spontaneous "mini" release and evoked synchronized neurotransmitter release, respectively. We used single vesicle-vesicle microscopy imaging to study the effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b994dbd282044acec5110042aedae333
https://doi.org/10.1021/ja407392n
https://doi.org/10.1021/ja407392n
The yeast vacuolar ABC transporter Ybt1p regulates membrane fusion through Ca2+ transport modulation
Publikováno v:
Biochemical Journal. 448:365-372
Ybt1p is a class C ABC transporter (ATP-binding cassette transporter) that is localized to the vacuole of Saccharomyces cerevisiae . Although Ybt1p was originally identified as a bile acid transporter, it has also been found to function in other capa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155c5c6dabfe9a1a09b9cbbad4856edc
https://doi.org/10.1042/bj20120847
https://doi.org/10.1042/bj20120847
Autor:
Jiajie Diao, Axel T. Brunger, Patricia Grob, Amie Nguyen, Sachi Shah, Marija Vrljic, Mark S. Padolina, Yunxiang Zhang, Eva Nogales, Ankita Shah, Ankita Srivastava, Minjoung Kyoung, Daniel J. Cipriano, Steven Chu
Publikováno v:
eLife
eLife, Vol 4 (2015)
eLife, Vol 4 (2015)
The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle-vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f17acd2821d28610e4a136edf97b7e
http://europepmc.org/articles/PMC4610116
http://europepmc.org/articles/PMC4610116
Autor:
Axel T. Brunger, Richard A. Pfuetzner, Mark S. Padolina, Daniel J. Cipriano, Yunxiang Zhang, Jiajie Diao, Ying Lai
Publikováno v:
eLife, Vol 3 (2014)
eLife
eLife
Previously we showed that fast Ca2+-triggered vesicle fusion with reconstituted neuronal SNAREs and synaptotagmin-1 begins from an initial hemifusion-free membrane point contact, rather than a hemifusion diaphragm, using a single vesicle–vesicle li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6f4e2812de89db6b427108d3a40f61
https://elifesciences.org/articles/03756
https://elifesciences.org/articles/03756
Autor:
Axel T. Brunger, Jiajie Diao, Amie Nguyen, Daniel J. Cipriano, Ankita Shah, Eva Nogales, Sachi Shah, Yunxiang Zhang, Mark S. Padolina, Marija Vrljic, Minjoung Kyoung, Ankita Srivastava, Patricia Grob, Steven Chu
Publikováno v:
eLife, vol 1, iss 1
eLife
eLife, Vol 1 (2012)
eLife
eLife, Vol 1 (2012)
The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle–vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc137b6e3b0a362f22fba20badada321
https://escholarship.org/uc/item/32r7t17m
https://escholarship.org/uc/item/32r7t17m
Autor:
Sheena N. Smith, Blake A. Flood, Mark S. Padolina, Rutilio A. Fratti, Terry L. Sasser, Surya Karunakaran, Anna Reyes, Quan-Sheng Qiu, Chad Gonzales
Publikováno v:
The Journal of biological chemistry. 287(3)
Vacuole homotypic fusion requires a group of regulatory lipids that includes diacylglycerol, a fusogenic lipid that is produced through multiple metabolic pathways including the dephosphorylation of phosphatidic acid (PA). Here we examined the relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c16a5155fd3a03d9dbd510a312f2ec
https://pubmed.ncbi.nlm.nih.gov/22121197
https://pubmed.ncbi.nlm.nih.gov/22121197