Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Mark S Dennis"'
Autor:
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport vehicle targeting the CD98 heavy chain (CD98hc or SLC3
Externí odkaz:
https://doaj.org/article/c0dcaba8ffc04890ade94c8b75b21509
Autor:
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a16cb8fb950d46f9ab274a050ec42452
Autor:
Henry R. Maun, Rajesh Vij, Benjamin T. Walters, Ashley Morando, Janet K. Jackman, Ping Wu, Alberto Estevez, Xiaocheng Chen, Yvonne Franke, Michael T. Lipari, Mark S. Dennis, Daniel Kirchhofer, Claudio Ciferri, Kelly M. Loyet, Tangsheng Yi, Charles Eigenbrot, Robert A. Lazarus, James T. Koerber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
β-tryptases are responsible for most of the proteolytic activity during mast cell activation. Here, the authors develop β-tryptase-inhibiting antibodies and provide structural and biochemical evidence that the bivalency of the antibodies is a prere
Externí odkaz:
https://doaj.org/article/731be2a1b0e94f0d9e6e6bb1c65b39da
Autor:
Scarlett J Barker, Mai B Thayer, Chaeyoung Kim, David Tatarakis, Matthew Simon, Rebekah L Dial, Lizanne Nilewski, Robert C Wells, Yinhan Zhou, Megan Afetian, Alfred Chappell, Kylie S Chew, Johann Chow, Allisa Clemens, Claire B Discenza, Jason Dugas, Chrissa Dwyer, Timothy Earr, Connie Ha, David Huynh, Srini Jayaraman, Wanda Kwan, Cathal Mahon, Michelle Pizzo, Elysia Roche, Laura Sanders, Alexander Stergioulis, Raymond Tong, Hai Tran, Joy Zuchero, Anthony A Estrada, Kapil Gadkar, Christopher MM Koth, Pascal E Sanchez, Robert G Thorne, Ryan J Watts, Thomas Sandmann, Lesley Kane, Frank Rigo, Mark S Dennis, Joseph W Lewcock, Sarah L DeVos
Antisense oligonucleotides (ASO) are promising therapies for neurological disorders, though they are unable to cross the blood-brain barrier (BBB) and must be delivered directly to the central nervous system (CNS). Here, we use a human transferrin re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56046f97df89d6a2d15a721b2fca4f31
https://doi.org/10.1101/2023.04.25.538145
https://doi.org/10.1101/2023.04.25.538145
Autor:
C. Andrew Boswell, Teemu T. Junttila, Saileta Prabhu, Mark S. Dennis, Sean B. Joseph, Kedan Lin, Klara Totpal, Robyn Clark, Maria Hristopoulos, Jason Ho, Dionysos Slaga, Jeffrey Eastham-Anderson, Ji Li, Amy A. Lo, Nene Takahashi, Danielle Mandikian
Anti-HER2/CD3, a T-cell–dependent bispecific antibody (TDB) construct, induces T-cell–mediated cell death in cancer cells expressing HER2 by cross-linking tumor HER2 with CD3 on cytotoxic T cells, thereby creating a functional cytolytic synapse.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60ecae480ffb1c898949cde0e394c25
https://doi.org/10.1158/1535-7163.c.6539608.v1
https://doi.org/10.1158/1535-7163.c.6539608.v1
Autor:
Susan D. Spencer, Mark S. Dennis, Sarajane Ross, Katherine R. Kozak, Aimee Fourie-O'Donohue, Gladys S. Ingle, Yin Zhang, Josefa Chuh, Elizabeth Luis, Vivian Barry-Hamilton, Linda Rangell, Hartmut Koeppen, Dorothy M. French, Ron Firestein, Glenn Pacheco, Nidhi Gupta, Suzie J. Scales
Supplementary Figure 1: IHC validation of anti-mesothelin antibody 19C3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b2e5317ebffc744b644e2646c06691
https://doi.org/10.1158/1535-7163.22501794.v1
https://doi.org/10.1158/1535-7163.22501794.v1
Autor:
Susan D. Spencer, Mark S. Dennis, Sarajane Ross, Katherine R. Kozak, Aimee Fourie-O'Donohue, Gladys S. Ingle, Yin Zhang, Josefa Chuh, Elizabeth Luis, Vivian Barry-Hamilton, Linda Rangell, Hartmut Koeppen, Dorothy M. French, Ron Firestein, Glenn Pacheco, Nidhi Gupta, Suzie J. Scales
Supplementary Table 2: Details of in vivo efficacy studies (# cells implanted; mouse strain, age and weight; tumor randomization volumes and IHC scores; % tumor growth inhibition and time to doubling versus vehicle).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a90c2eab2405a86d366643a0bc81d6
https://doi.org/10.1158/1535-7163.22501773
https://doi.org/10.1158/1535-7163.22501773
Autor:
Susan D. Spencer, Mark S. Dennis, Sarajane Ross, Katherine R. Kozak, Aimee Fourie-O'Donohue, Gladys S. Ingle, Yin Zhang, Josefa Chuh, Elizabeth Luis, Vivian Barry-Hamilton, Linda Rangell, Hartmut Koeppen, Dorothy M. French, Ron Firestein, Glenn Pacheco, Nidhi Gupta, Suzie J. Scales
Supplementary Table 1: Summary of 5B2 anti-mesothelin IHC literature and TMA details.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d497fc929ae9d73af4196930e0c3172
https://doi.org/10.1158/1535-7163.22501776
https://doi.org/10.1158/1535-7163.22501776
Autor:
Susan D. Spencer, Mark S. Dennis, Sarajane Ross, Katherine R. Kozak, Aimee Fourie-O'Donohue, Gladys S. Ingle, Yin Zhang, Josefa Chuh, Elizabeth Luis, Vivian Barry-Hamilton, Linda Rangell, Hartmut Koeppen, Dorothy M. French, Ron Firestein, Glenn Pacheco, Nidhi Gupta, Suzie J. Scales
Supplemental ancillary methods (ELISA, surface plasmon resonance and humanization) and 4 supplemental figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b35fe9f3317ec9ed5c02b37f7fed0df
https://doi.org/10.1158/1535-7163.22501782.v1
https://doi.org/10.1158/1535-7163.22501782.v1
Autor:
Jagath R. Junutula, Paul Polakis, Richard H. Scheller, Mark S. Dennis, Deepak Sampath, Jo-Anne Hongo, Helga Raab, Katherine R. Kozak, Aimee Fourie-O'Donohue, Ron Firestein, Robert Piskol, Eric Cheng, Mary Ann T. Go, Kirsten A. Poon, Fiona Zhong, Rachana Ohri, Coenraad Kuijl, Dongwei Li, Melissa M. Schutten, Meredith Hazen, Yvonne Chen, Lisa M. Crocker, Sunil Bhakta
Luminal A (hormone receptor-positive) breast cancer constitutes 70% of total breast cancer patients. In an attempt to develop a targeted therapeutic for this cancer indication, we have identified and characterized Glial cell line–Derived Neurotroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ebbf88322d045b6d0c4b08c2c22021d
https://doi.org/10.1158/1535-7163.c.6537960.v1
https://doi.org/10.1158/1535-7163.c.6537960.v1