High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome.

Autor: Sergey A Shiryaev, Andrei V Chernov, Vladislav S Golubkov, Elliot R Thomsen, Eugene Chudin, Mark S Chee, Igor A Kozlov, Alex Y Strongin, Piotr Cieplak

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e54290 (2013)

There is a growing appreciation of the role of proteolytic processes in human health and disease, but tools for analysis of such processes on a proteome-wide scale are limited. Furin is a ubiquitous proprotein convertase that cleaves after basic resi

Externí odkaz: https://doaj.org/article/7b1d91af66f44fd980f1353c226f6f79

A highly scalable peptide-based assay system for proteomics.

Autor: Igor A Kozlov, Elliot R Thomsen, Sarah E Munchel, Patricia Villegas, Petr Capek, Austin J Gower, Stephanie J K Pond, Eugene Chudin, Mark S Chee

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e37441 (2012)

We report a scalable and cost-effective technology for generating and screening high-complexity customizable peptide sets. The peptides are made as peptide-cDNA fusions by in vitro transcription/translation from pools of DNA templates generated by mi

Externí odkaz: https://doaj.org/article/39b437ef36004202a64af372d02d7291

Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with an endemic human CoV

Autor: Jason T Ladner, Sierra N Henson, Annalee S Boyle, Anna L Engelbrektson, Zane W Fink, Fatima Rahee, Jonathan D’ambrozio, Kurt E Schaecher, Mars Stone, Wenjuan Dong, Sanjeet Dadwal, Jianhua Yu, Michael A Caligiuri, Piotr Cieplak, Magnar Bjørås, Mona H Fenstad, Svein A Nordbø, Denis E Kainov, Norihito Muranaka, Mark S Chee, Sergey A Shiryaev, John A Altin

Publikováno v: bioRxiv : the preprint server for biology.

A high-resolution understanding of the antibody response to SARS-CoV-2 is important for the design of effective diagnostics, vaccines and therapeutics. However, SARS-CoV-2 antibody epitopes remain largely uncharacterized, and it is unknown whether an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8133390e81a05f8024c20170b407dce6
https://pubmed.ncbi.nlm.nih.gov/33495758

Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses

Autor: Kurt E. Schaecher, Mars Stone, Sierra N. Henson, Wenjuan Dong, Norihito Muranaka, Sergey A. Shiryaev, Jonathan D'ambrozio, John A. Altin, Piotr Cieplak, Jianhua Yu, Mona H. Fenstad, Jason T. Ladner, Sanjeet Dadwal, Magnar Bjørås, Svein Arne Nordbø, Annalee S. Boyle, Michael A. Caligiuri, Anna Engelbrektson, Zane Fink, Mark S. Chee, Fatima Rahee, Denis E. Kainov

Publikováno v: Cell Reports Medicine
bioRxiv
article-version (status) pre
article-version (number) 1

The SARS-CoV-2 proteome shares regions of conservation with endemic human coronaviruses (CoVs), but it remains unknown to what extent these may be cross-recognized by the antibody response. Here, we study cross-reactivity using a highly multiplexed p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd463148630856d2ef5ab47299676987
http://europepmc.org/articles/PMC7816965

The International HapMap Project

Autor: Jessica Watkin, Stacey Gabriel, Norio Niikawa, Michael Boehnke, Lincoln Stein, Karen Kennedy, Mark Leppert, Renzong Qiu, John Stewart, Peter E. Chen, Panos Deloukas, Wei Huang, Deborah A. Nickerson, Fuli Yu, Sarah E. Hunt, Ming Xiao, Francis S. Collins, Fiona Cunningham, Stephen F. Schaffner, Yoshimitsu Fukushima, Jonathan Marchini, Troy Duster, Jane Peterson, Koki Sorimachi, Michael Feolo, Bruce S. Weir, Paul L'Archevêque, Raymond D. Miller, Hongguang Wang, Toyin Aniagwu, Mildred K. Cho, Darryl Macer, Qingrun Zhang, Paul K.H. Tam, Ardavan Kanani, Guy Bellemare, Thomas D. Willis, Mark Shillito, Martin Leboeuf, Lynn F. Zacharia, Pilar N. Ossorio, Charmaine D.M. Royal, Paul Hardenbol, Yusuke Nakamura, Maria Jasperse, Pui-Yan Kwok, Mark S. Guyer, Bin Liu, Leonid Kruglyak, Huanming Yang, Aravinda Chakravarti, John W. Belmont, Ellen Wright Clayton, Jane Rogers, Arnold Oliphant, Jack Spiegel, Houcan Zhang, Stephen T. Sherry, Vincent Ferretti, Julio Licinio, Toshihiro Tanaka, Richard R. Hudson, Mary M.Y. Waye, Lon R. Cardon, Elke Jordan, Gonçalo R. Abecasis, Kazuto Kato, Vivian Ota Wang, Gilean McVean, Lawrence M. Sung, Don Powell, Patricia A. Marshall, Patricia Spallone, Lan Yang Ch'Ang, Alastair Kent, James C. Mullikin, Eric S. Lander, Lucinda Fulton, Michael S. Phillips, Jeffrey Tze Fei Wong, David Valle, Fanny Chagnon, Semyon Kruglyak, Tatsuhiko Tsunoda, Hua Han, John P. Rice, David J. Cutler, Mark J. Daly, Peter Donnelly, Yan Shen, Jean E. McEwen, Andrew P. Morris, Richard Seabrook, Luana Galver, Thomas J. Hudson, Chibuzor Nkwodimmah, Clement Adebamowo, Lisa D. Brooks, Arthur L. Holden, Robert L. Nussbaum, David R. Bentley, Jeffrey C. Long, Nancy L. Saccone, Michael Dunn, Charles N. Rotimi, Sarah S. Murray, Richard A. Gibbs, Simon Myers, George M. Weinstock, Bartha Maria Knoppers, Takashi Fujita, Julie A. Douglas, Georgia M. Dunston, Richard K. Wilson, Sharon F. Terry, Kazuo Todani, Akihiro Sekine, Barbara Skene, Martin Godbout, David Altshuler, Bruce W. Birren, Lynn B. Jorde, Mark S. Chee, Olayemi Matthew, Erica Sodergren, Lap-Chee Tsui, Changqing Zeng, John C. Wallenburg, Missy Dixon, Gudmundur A. Thorisson, Ichiro Matsuda, Andrei Verner, Carl S. Kashuk, Eiji Yoshino, Patricia Taillon-Miller, Morris W. Foster, Satoshi Tanaka, Alexandre Montpetit, Yoichi Tanaka, Denise L. Lind, Eric H. Lai, Eiko Suda, Shenghui Duan

The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b68509775c60ce3a8e33fadcb656b72
https://ora.ox.ac.uk/objects/uuid:64fb68cf-6299-4b37-9248-e41084f26570