Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Mark S, Shapiro"'
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
We investigated the contribution of excitatory transient receptor potential canonical (TRPC) cation channels to posttraumatic hyperexcitability in the brain 7 days following controlled cortical impact model of traumatic brain injury (TBI) to the pari
Externí odkaz:
https://doaj.org/article/82acaacb1a83472a8e7534a1596ed35b
Autor:
Grant Dixon, Steven Potter, Mark S. Shapiro, Emma Santa Maria, David Schmidt, Daniel Santa Maria
Publikováno v:
Current Sports Medicine Reports. 22:164-167
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d8872e0bb6a1dcb28be7c135d62499a
https://doi.org/10.1249/jsr.0000000000001062
https://doi.org/10.1249/jsr.0000000000001062
Autor:
Tarek Mohamed Abd El-Aziz, Amanpreet Kaur, Mark S. Shapiro, James D. Stockand, Crystal R. Archer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3884 (2022)
The activity of the epithelial Na+ Channel (ENaC) is strongly dependent on the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 binds two distinct cationic clusters within the N termini of β- and γ-ENaC subunits (βN1 and γ
Externí odkaz:
https://doaj.org/article/7171b632a30241ad81ce59a6a29534b0
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Kv7 (“M-type,” KCNQ) K+ currents, play dominant roles in controlling neuronal excitability. They act as a “brake” against hyperexcitable states in the central and peripheral nervous systems. Pharmacological augmentation of M current has been
Externí odkaz:
https://doaj.org/article/e6cc7fe49bca467da1072daca88a96b2
Autor:
Fabio A. Vigil, Hindiael Belchior, Vladislav Bugay, Isabella I. Bazaldua, Aiola Stoja, Denise C. Dantas, Sang H. Chun, Austin Farmer, Eda Bozdemir, Deborah M. Holstein, Jose E. Cavazos, James D. Lechleiter, Robert Brenner, Mark S. Shapiro
Publikováno v:
Neurotherapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c18ef93ccb19e3009a245dfbdb0238db
https://doi.org/10.1007/s13311-023-01361-9
https://doi.org/10.1007/s13311-023-01361-9
Autor:
Luke E Whitmire, Ling Ling, Vladslav Bugay, Chase M Carver, Santosh Timilsina, Hui-Hsiu Chuang, David B Jaffe, Mark S Shapiro, Jose E Cavazos, Robert Brenner
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188064 (2017)
A major challenge is to understand maladaptive changes in ion channels that sets neurons on a course towards epilepsy development. Voltage- and calcium-activated K+ (BK) channels contribute to early spike timing in neurons, and studies indicate that
Externí odkaz:
https://doaj.org/article/d4f281d15dae414db4babdee93ae8b4e
Publikováno v:
Hippocampus
M-type (KCNQ2/3) K(+) channels play dominant roles in regulation of active and passive neuronal discharge properties such as resting membrane potential, spike-frequency adaptation, and hyper-excitatory states. However, plasticity of M-channel express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc0d7439f186d1218948d75731e5668
https://doi.org/10.1002/hipo.23163
https://doi.org/10.1002/hipo.23163
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145367 (2015)
In the central and peripheral nervous system, the assembly of KCNQ3 with KCNQ2 as mostly heteromers, but also homomers, underlies "M-type" currents, a slowly-activating voltage-gated K+ current that plays a dominant role in neuronal excitability. KCN
Externí odkaz:
https://doaj.org/article/22a2692ee5404606a8d3c0b3b924b701
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 15 (2021)
Frontiers in Neuroscience, Vol 15 (2021)
We investigated the contribution of excitatory transient receptor potential canonical (TRPC) cation channels to posttraumatic hyperexcitability in the brain 7 days following controlled cortical impact model of traumatic brain injury (TBI) to the pari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bf572483c5270bb1740ce7516477cf
https://doi.org/10.3389/fnins.2021.681144
https://doi.org/10.3389/fnins.2021.681144
Autor:
Shayne D. Hastings, Rafael J. Veraza, Deborah M. Holstein, Isamar Sanchez, Sang H Chun, Mark S. Shapiro, MaryAnn Hobbs, Robert Brenner, José E Cavazos, Shane Sprague, Chase M. Carver, Fabio A. Vigil, Eda Bozdemir, Vladislav Bugay, James D. Lechleiter
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 40:1256-1273
Nearly three million people in the USA suffer traumatic brain injury (TBI) yearly; however, there are no pre- or post-TBI treatment options available. KCNQ2-5 voltage-gated K+ channels underlie the neuronal “M current”, which plays a dominant rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d470768f417518b0239f08f0545b7b0
https://doi.org/10.1177/0271678x19857818
https://doi.org/10.1177/0271678x19857818