Mechanisms of GNAL linked dystonia

Autor: Mark S. Moehle

Publikováno v: Dystonia, Vol 3 (2024)

Mutations in the GNAL gene, encoding Gαolf, are causative for an adult-onset, isolated dystonia that may provide unique insights into the etiology of adult-onset idiopathic dystonia. Gαolf is an alpha subunit of heterotrimeric G protein that replac

Externí odkaz: https://doaj.org/article/f16060572ec14beda0002fe796b96909

Corrigendum to 'α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration' [Neurobiol. Dis., Volume 105 (2017) Article 84, 98]

Autor: Hisham Abdelmotilib, Tyler Maltbie, Vedad Delic, Zhiyong Liu, Xianzhen Hu, Kyle B. Fraser, Mark S. Moehle, Lindsay Stoyka, Nadia Anabtawi, Valentina Krendelchtchikova, Laura A. Volpicelli-Daley, Andrew West

Publikováno v: Neurobiology of Disease, Vol 159, Iss , Pp 105506- (2021)

Externí odkaz: https://doaj.org/article/93d0990612304cb6b991a966e258431a

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

Autor: Hisham Abdelmotilib, Tyler Maltbie, Vedad Delic, Zhiyong Liu, Xianzhen Hu, Kyle B. Fraser, Mark S. Moehle, Lindsay Stoyka, Nadia Anabtawi, Valentina Krendelchtchikova, Laura A. Volpicelli-Daley, Andrew West

Publikováno v: Neurobiology of Disease, Vol 105, Iss , Pp 84-98 (2017)

Proteinaceous inclusions in neurons, composed primarily of α-synuclein, define the pathology in several neurodegenerative disorders. Neurons can internalize α-synuclein fibrils that can seed new inclusions from endogenously expressed α-synuclein.

Externí odkaz: https://doaj.org/article/347b02afbcd14d3d81e45e37ff8d7b1b

Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy

Autor: Jerri M. Rook, Aaron M. Bender, Colleen M. Niswender, Yuping Donsante, P. Jeffrey Conn, Hyekyung P. Cho, Li Peng, Julie L. Engers, Jonathan W. Dickerson, Thomas M. Bridges, Craig W. Lindsley, Ellen J. Hess, Sichen Chang, Aidong Qi, Weimin Peng, Mark S. Moehle, Jordan C. O’Neill, Daniel J. Foster, Alice L. Rodriguez, Zoey Bryant, Katherine J. Watson, Kaylee J. Stillwell

Publikováno v: ACS Pharmacology & Translational Science. 4:1306-1321

Nonselective antagonists of muscarinic acetylcholine receptors (mAChRs) that broadly inhibit all five mAChR subtypes provide an efficacious treatment for some movement disorders, including Parkinson's disease and dystonia. Despite their efficacy in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5425dfe0a6fb74da410878130ec6660
https://doi.org/10.1021/acsptsci.0c00162

Cholinergic system changes in Parkinson's disease:emerging therapeutic approaches

Autor: Nicolaas I Bohnen, Alison J Yarnall, Rimona S Weil, Elena Moro, Mark S Moehle, Per Borghammer, Marc-André Bedard, Roger L Albin

Publikováno v: Bohnen, N I, Yarnall, A J, Weil, R S, Moro, E, Moehle, M S, Borghammer, P, Bedard, M-A & Albin, R L 2022, ' Cholinergic system changes in Parkinson's disease : emerging therapeutic approaches ', Lancet Neurology, vol. 21, no. 4, pp. 381-392 . https://doi.org/10.1016/S1474-4422(21)00377-X
Lancet Neurol

In patients with Parkinson's disease, heterogeneous cholinergic system changes can occur in different brain regions. These changes correlate with a range of clinical features, both motor and non-motor, that are refractory to dopaminergic therapy, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5297605f123e81e16f614e8c8853621d
https://pure.au.dk/portal/da/publications/cholinergic-system-changes-in-parkinsons-disease(a4381a46-0dd4-4f8f-94eb-384fe7259a71).html