Zobrazeno 1 - 10
of 634
pro vyhledávání: '"Mark S, Johnson"'
Publikováno v:
Molecules, Vol 29, Iss 15, p 3451 (2024)
The superfamily of acid proteases has two catalytic aspartates for proteolysis of their peptide substrates. Here, we show a minimal structural scaffold, the structural catalytic core (SCC), which is conserved within each family of acid proteases, but
Externí odkaz:
https://doaj.org/article/b3fce8cb48fe43c9bc9fd0860cbdfa5c
Autor:
Konstantin Denessiouk, Alexander I. Denesyuk, Sergei E. Permyakov, Eugene A. Permyakov, Mark S. Johnson, Vladimir N. Uversky
Publikováno v:
Current Research in Structural Biology, Vol 7, Iss , Pp 100123- (2024)
SGNH hydrolase-like fold proteins are serine proteases with the default Asp-His-Ser catalytic triad. Here, we show that these proteins share two unique conserved structural organizations around the active site: (1) the Nuc-Oxy Zone around the catalyt
Externí odkaz:
https://doaj.org/article/1098fa70563b46f4be0235157daee249
Autor:
Katri Vaparanta, Anne Jokilammi, Mahlet Tamirat, Johannes A. M. Merilahti, Kari Salokas, Markku Varjosalo, Johanna Ivaska, Mark S. Johnson, Klaus Elenius
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Specificity in signaling activated by receptor tyrosine kinases is typically attributed to characteristics of their intracellular domains. Here, the authors demonstrate that an extracellular receptor sequence motif controls intracellular signaling as
Externí odkaz:
https://doaj.org/article/a1f72bfdc3b24f3ba724cff785319be7
Publikováno v:
Journal of Advances in Modeling Earth Systems, Vol 15, Iss 7, Pp n/a-n/a (2023)
Abstract Although evapotranspiration (ET) from the land is a key variable in Earth system models, the accurate estimation of ET based on physical principles remains challenging. Parameters used in current ET models are largely empirically based, whic
Externí odkaz:
https://doaj.org/article/ab5932b7c76a4c4d9464b5cd6e1c02fe
Autor:
Lisa Gawriyski, Eeva-Mari Jouhilahti, Masahito Yoshihara, Liangru Fei, Jere Weltner, Tomi T. Airenne, Ras Trokovic, Shruti Bhagat, Mari H. Tervaniemi, Yasuhiro Murakawa, Kari Salokas, Xiaonan Liu, Sini Miettinen, Thomas R. Bürglin, Biswajyoti Sahu, Timo Otonkoski, Mark S. Johnson, Shintaro Katayama, Markku Varjosalo, Juha Kere
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106172- (2023)
Summary: The paired-like homeobox transcription factor LEUTX is expressed in human preimplantation embryos between the 4- and 8-cell stages, and then silenced in somatic tissues. To characterize the function of LEUTX, we performed a multiomic charact
Externí odkaz:
https://doaj.org/article/1b78c910dbd44d44b717a1317ad6a139
Publikováno v:
Earth's Future, Vol 11, Iss 2, Pp n/a-n/a (2023)
Abstract The magnitude and extent of runoff reduction, drought intensification, and dryland expansion under climate change are unclear and contentious. A primary reason is disagreement between global circulation models and current potential evaporati
Externí odkaz:
https://doaj.org/article/b5b16d9ff5c54d0a9c2e4de88dd7ea7d
Publikováno v:
Water Alternatives, Vol 14, Iss 2, Pp 573-596 (2021)
Soil moisture conservation ('green water') and runoff capture ('blue water') can reduce agricultural risks to rainfall variation. However, little is known about how such conjoined initiatives articulate with social inequity when up-scaled into formal
Externí odkaz:
https://doaj.org/article/5a532a23bd2c4b1890e27a5fae7d1a19
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The boreal forest is among the largest terrestrial biomes on earth, storing more carbon (C) than the atmosphere. Due to rapid climatic warming and enhanced human development, the boreal region may have begun transitioning from a net C sink t
Externí odkaz:
https://doaj.org/article/e9881fda05a5406c8600f790864918fd
Autor:
Mark S. Johnson, Valerie H. Adams
Publikováno v:
Toxics, Vol 11, Iss 3, p 280 (2023)
Ensuring for the national defense requires the use of substances such as energetics, propellants, pyrotechnics, and other materials in environmental applications. Systems that use these materials do so in testing and training environments and must be
Externí odkaz:
https://doaj.org/article/0a0017588db94cb1ad99057a470ec210
Autor:
Sanna Vuoristo, Shruti Bhagat, Christel Hydén-Granskog, Masahito Yoshihara, Lisa Gawriyski, Eeva-Mari Jouhilahti, Vipin Ranga, Mahlet Tamirat, Mikko Huhtala, Ida Kirjanov, Sonja Nykänen, Kaarel Krjutškov, Anastassius Damdimopoulos, Jere Weltner, Kosuke Hashimoto, Gaëlle Recher, Sini Ezer, Priit Paluoja, Pauliina Paloviita, Yujiro Takegami, Ai Kanemaru, Karolina Lundin, Tomi T. Airenne, Timo Otonkoski, Juha S. Tapanainen, Hideya Kawaji, Yasuhiro Murakawa, Thomas R. Bürglin, Markku Varjosalo, Mark S. Johnson, Timo Tuuri, Shintaro Katayama, Juha Kere
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104137- (2022)
Summary: Double homeobox 4 (DUX4) is expressed at the early pre-implantation stage in human embryos. Here we show that induced human DUX4 expression substantially alters the chromatin accessibility of non-coding DNA and activates thousands of newly i
Externí odkaz:
https://doaj.org/article/e20d78e8cdab451083fb4b3f94c08b7f