Výsledky vyhledávání - "Mark S, Butler"

Akademický článek

Cobdock: an accurate and practical machine learning-based consensus blind docking method

Autor: Sadettin Y. Ugurlu, David McDonald, Huangshu Lei, Alan M. Jones, Shu Li, Henry Y. Tong, Mark S. Butler, Shan He

Publikováno v: Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-19 (2024)

Abstract Probing the surface of proteins to predict the binding site and binding affinity for a given small molecule is a critical but challenging task in drug discovery. Blind docking addresses this issue by performing docking on binding regions ran

Externí odkaz: https://doaj.org/article/001a3fa967f9469b8b1c42f848bc17ec

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Akademický článek

Synthesis of vancomycin fluorescent probes that retain antimicrobial activity, identify Gram-positive bacteria, and detect Gram-negative outer membrane damage

Autor: Bing Zhang, Wanida Phetsang, M. Rhia L. Stone, Sanjaya Kc, Mark S. Butler, Matthew A. Cooper, Alysha G. Elliott, Urszula Łapińska, Margaritis Voliotis, Krasimira Tsaneva-Atanasova, Stefano Pagliara, Mark A. T. Blaskovich

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)

Abstract Antimicrobial resistance is an urgent threat to human health, and new antibacterial drugs are desperately needed, as are research tools to aid in their discovery and development. Vancomycin is a glycopeptide antibiotic that is widely used fo

Externí odkaz: https://doaj.org/article/91aa1c2ad9ed465bac7ff7a0422f2845

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Akademický článek

Curcuma longa rhizome extract and Curcumin reduce the adhesion of Acanthamoeba triangularis trophozoites and cysts in polystyrene plastic surface and contact lens

Autor: Watcharapong Mitsuwan, Suthinee Sangkanu, Chonticha Romyasamit, Chalermpon Kaewjai, Tajudeen O. Jimoh, Maria de Lourdes Pereira, Abolghasem Siyadatpanah, Sunil Kayesth, Muhammad Nawaz, Mohammed Rahmatullah, Mark S. Butler, Polrat Wilairatana, Christophe Wiart, Veeranoot Nissapatorn

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 14, Iss , Pp 218-229 (2020)

Curcuma longa and Curcumin have been documented to have a wide spectrum of pharmacological effects, including anti-Acanthamoeba activity. Hence, this study sought to explore the anti-adhesion activity of C. longa extract and Curcumin against Acantham

Externí odkaz: https://doaj.org/article/f10b6e5020114b83bb34f15ffc1dbdae

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Akademický článek

An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria

Autor: Alysha G. Elliott, Johnny X. Huang, Søren Neve, Johannes Zuegg, Ingrid A. Edwards, Amy K. Cain, Christine J. Boinett, Lars Barquist, Carina Vingsbo Lundberg, Jason Steen, Mark S. Butler, Mehdi Mobli, Kaela M. Porter, Mark A. T. Blaskovich, Sergio Lociuro, Magnus Strandh, Matthew A. Cooper

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Peptide antibiotics often display a very narrow therapeutic index. Here, the authors present an optimized peptide antibiotic with broad-spectrum in vitro activities, in vivo efficacy in multiple disease models against multidrug-resistant Gram-negativ

Externí odkaz: https://doaj.org/article/c52da634b87d440cbbc0c10a3c254c56

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Akademický článek

Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials

Autor: Mazdida Sulaiman, Khoshnur Jannat, Veeranoot Nissapatorn, Mohammed Rahmatullah, Alok K. Paul, Maria de Lourdes Pereira, Mogana Rajagopal, Monica Suleiman, Mark S. Butler, Mohammed Khaled Bin Break, Jean-Frédéric Weber, Polrat Wilairatana, Christophe Wiart

Publikováno v: Antibiotics, Vol 11, Iss 9, p 1146 (2022)

The emergence of multidrug-resistant bacteria and fungi requires the development of antibiotics and antifungal agents. This review identified natural products isolated from Asian angiosperms with antibacterial and/or antifungal activities and analyze

Externí odkaz: https://doaj.org/article/e6e3b2b2dedf489e806d129a3fd4a310

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Akademický článek

Isolation and Characterization of Werneria Chromene and Dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle

Publikováno v: Plants, Vol 11, Iss 11, p 1388 (2022)

The secondary metabolites of endemic plants from the Rutaceae family, such as Burkillanthusmalaccensis (Ridl.) Swingle from the rainforest of Malaysia, has not been studied. Burkillanthusmalaccensis (Ridl.) Swingle may produce antibacterial and antib

Externí odkaz: https://doaj.org/article/cb388903d25346ec90d5d38d212aa56e

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Akademický článek

Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

The antibiotic vancomycin inhibits bacterial cell wall synthesis by binding to a membrane-associated precursor. Here, Blaskovich et al. synthesize vancomycin derivatives containing lipophilic peptide moieties that enhance membrane affinity and in viv

Externí odkaz: https://doaj.org/article/5939bc54d4b347d7b1b16946d6d5c490

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Discovery of brevijanazines from Aspergillus brevijanus reveals the molecular basis for p-nitrobenzoic acid in fungi

Autor: Hang Li, Paul M. Mirzayans, Mark S. Butler, Alastair E. Lacey, Daniel Vuong, Rachel Chen, John A. Kalaitzis, Stephen A. Moggach, Ernest Lacey, Andrew M. Piggott, Yit-Heng Chooi

Publikováno v: Chemical Communications. 58:6296-6299

The discovery of a novel family of p-nitrobenzoylated piperazines from Aspergillus brevijanus revealed that the biosynthesis of p-nitrobenzoic acid in fungi is catalysed by a PABA synthase, an aminodeoxychorismate synthase and a cytochrome P450.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce7aaa6721caf995642569850034abfe
https://doi.org/10.1039/d2cc01679f

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