Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Mark Roest"'
Autor:
Jinmi Zou, Siyu Sun, Ilaria De Simone, Hugo ten Cate, Philip G. de Groot, Bas de Laat, Mark Roest, Johan W.M. Heemskerk, Frauke Swieringa
Publikováno v:
TH Open, Vol 08, Iss 02, Pp e232-e242 (2024)
Background Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This is considered reversible under specific conditions, allowing a second phase of platelet aggregation. The signal
Externí odkaz:
https://doaj.org/article/a1a44a63b65c416f94bc44b92ad11959
Autor:
Sandra Konrath, Reiner K. Mailer, Manu Beerens, Hanna Englert, Maike Frye, Piotr Kuta, Roger J. S. Preston, Coen Maas, Lynn M. Butler, Mark Roest, Bas de Laat, Thomas Renné
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Calibrated Automated Thrombography (CAT) is a versatile and sensitive method for analyzing coagulation reactions culminating in thrombin generation (TG). Here, we present a CAT method for analyzing TG in murine whole blood by adapting the CAT assay u
Externí odkaz:
https://doaj.org/article/ea917332e07143deb5c08fe5ee31705f
Autor:
Gurbey Ocak, Mark Roest, Marianne C. Verhaar, Maarten B. Rookmaaker, Peter J. Blankestijn, Willem Jan W. Bos, Rob Fijnheer, Nathalie C. Péquériaux, Friedo W. Dekker
Publikováno v:
BMC Nephrology, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background Von Willebrand Factor (VWF) multimers are cleaved into smaller and less coagulant forms by the metalloprotease ADAMTS13. The aim of this study was to investigate the association between VWF and ADAMTS13 and mortality in dialysis p
Externí odkaz:
https://doaj.org/article/ea26eec955a84e69841cb0bcf0a6601e
Autor:
Bas de Laat, Hendrik Stragier, Romy de Laat-Kremers, Marisa Ninivaggi, Dieter Mesotten, Steven Thiessen, Kristien Van Pelt, Mark Roest, Joris Penders, Pascal Vanelderen, Dana Huskens, Raf De Jongh, Margot Vander Laenen, Tom Fivez, Hugo ten Cate, Rene Heylen, Line Heylen, Deborah Steensels
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Various vaccines were developed to reduce the spread of the Severe Acute Respiratory Syndrome Cov-2 (SARS-CoV-2) virus. Quickly after the start of vaccination, reports emerged that anti-SARS-CoV-2 vaccines, including ChAdOx1-S, could be associated wi
Externí odkaz:
https://doaj.org/article/b72aca7513404bef82e61120a14e241b
Autor:
Li Li, Mark Roest, Yaqiu Sang, Jasper A. Remijn, Rob Fijnheer, Karel Smit, Dana Huskens, Jun Wan, Bas de Laat, Joke Konings
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundMultiple myeloma (MM) is associated with a high prevalence of bleeding and an increased risk of thrombo-embolism. MM patients have reduced platelet- and red blood cell (RBC) numbers in blood, which may indicate that the paradoxical hemostas
Externí odkaz:
https://doaj.org/article/0d66f83f52b04071a69dc6fe0b64501d
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-4 (2020)
Externí odkaz:
https://doaj.org/article/3fcd641f4bc44421bdc1580fb57ba28f
Autor:
Shengshi Huang, Wouter van der Heijden, Isaie J Reuling, Jun Wan, Qiuting Yan, Romy M W de Laat-Kremers, Andre J Van der Ven, Philip G de Groot, Matthew McCall, Robert W Sauerwein, Teun Bousema, Mark Roest, Marisa Ninivaggi, Quirijn de Mast, Bas de Laat
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271527 (2022)
Decreased platelet count is an early phenomenon in asexual Plasmodium falciparum parasitemia, but its association with acute or long-term functional changes in platelets and coagulation is unknown. Moreover, the impact of gametocytemia on platelets a
Externí odkaz:
https://doaj.org/article/57d4f62c196b49c3a20f91058c32d171
Autor:
Jinmi Zou, Frauke Swieringa, Bas de Laat, Philip G. de Groot, Mark Roest, Johan W. M. Heemskerk
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12512 (2022)
Integrin αIIbβ3 activation is essential for platelet aggregation and, accordingly, for hemostasis and arterial thrombosis. The αIIbβ3 integrin is highly expressed on platelets and requires an activation step for binding to fibrinogen, fibrin or v
Externí odkaz:
https://doaj.org/article/78af5d4a541245bfb5f495e6bdd67701
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247425 (2021)
Platelets can respond to multiple antagonists and agonists, implying that their activation state is a consequence of past exposure to these substances. While platelets are often considered as one-time responsive cells, they likely can respond to sequ
Externí odkaz:
https://doaj.org/article/57b6c2a369414ba6982d80d8012fae39
Autor:
Lisa N. van der Vorm, Dana Huskens, Lisa Florin, Pieter De Kesel, Mark Roest, Bas de Laat, Katrien M.J. Devreese
Publikováno v:
Thrombosis Update, Vol 1, Iss , Pp 100001- (2020)
Introduction: Increased levels of circulating von Willebrand Factor (VWF) in its active, platelet-binding conformation have been implicated in the pathogenesis of several thrombotic conditions as well as bleeding conditions characterized by severe th
Externí odkaz:
https://doaj.org/article/39267ebe55af42f6ae241601af45c90f