Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mark Reppell"'
Autor:
Mark Reppell, John Novembre
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 4, p e1006096 (2018)
Pooled DNA from multiple unknown organisms arises in a variety of contexts, for example microbial samples from ecological or human health research. Determining the composition of pooled samples can be difficult, especially at the scale of modern sequ
Externí odkaz:
https://doaj.org/article/6d8a5c04dbb04811b78eed24dabda9a5
Autor:
Konrad J. Karczewski, Matthew Solomonson, Katherine R. Chao, Julia K. Goodrich, Grace Tiao, Wenhan Lu, Bridget M. Riley-Gillis, Ellen A. Tsai, Hye In Kim, Xiuwen Zheng, Fedik Rahimov, Sahar Esmaeeli, A. Jason Grundstad, Mark Reppell, Jeff Waring, Howard Jacob, David Sexton, Paola G. Bronson, Xing Chen, Xinli Hu, Jacqueline I. Goldstein, Daniel King, Christopher Vittal, Timothy Poterba, Duncan S. Palmer, Claire Churchhouse, Daniel P. Howrigan, Wei Zhou, Nicholas A. Watts, Kevin Nguyen, Huy Nguyen, Cara Mason, Christopher Farnham, Charlotte Tolonen, Laura D. Gauthier, Namrata Gupta, Daniel G. MacArthur, Heidi L. Rehm, Cotton Seed, Anthony A. Philippakis, Mark J. Daly, J. Wade Davis, Heiko Runz, Melissa R. Miller, Benjamin M. Neale
Publikováno v:
Cell Genomics. 2:100168
Autor:
Timothy R. Orchard, Rosemary H Phillips, Stephen M. Evans, Arvind Ramadas, Paul R. Banim, Guy Chung-Faye, Subramaniam Ramakrishnan, Simon Panter, Leonie Grellier, Hasnain Jafferbhoy, Nigel Trudgill, Thankam Paul, Sian Kirkham, Anna J Pigott, M J Carter, Juan De La Revella Negro, Lisa Gervais, Zia Mazhar, Suranga Dharmisari, Richard A. Miller, Cathryn Preston, Alison Simmons, Rachel Cooney, Natalie C. Direkze, Deb Ghosh, Christian P. Selinger, Andrew A. Fagbemi, Rakesh Chaudhary, J R Fraser Cummings, Stephen Gore, James O. Lindsay, Tony C.K. Tham, David Hobday, Charles Murray, David Watts, Anne Willmott, Gill Watts, Sandip Sen, Mark Reppell, Amer Azaz, Shaji Sebastian, Neil Chanchlani, R B Johnston, Ben Hope, Salil Singh, Stephen Foley, Sunil Sonwalkar, Jonathon Snook, Lawrence Armstrong, Amanda Beale, Andy Li, Tariq Mahmood, Stephen Lewis, Kevin J. Monahan, Timothy J. McDonald, Gareth T. Jones, John N. Gordon, Nicholas A Kennedy, Sheldon C. Cooper, Gareth J. Walker, James W Hart, Sarah Langlands, Carl A. Anderson, Marcus Harbord, Alistair McNair, Achuth Shenoy, Graham A. Heap, Radhakrishnan Hariraj, Mandy H Perry, Charlie Lees, Shanika de Silva, Christopher J. Hawkey, Loukas Moutsianas, Matthew J Brookes, Christos Tzivinikos, Veena Zamvar, Cathryn Edwards, Claire Bell, Rebecca Saich, Peter M. Irving, Mark S. Smith, Phillip Mayhead, Christopher Macdonald, Dharamveer Basude, Andrew T. Cole, Ailsa Hart, Daniel R. Gaya, Kasamu Dawa Kabiru, Assad Butt, John C Mansfield, John Beckly, Anton V J Gunasekera, Simon Lal, Charles Pj Charlton, Astor Rodrigues, Craig Mowat, Joel Mawdsley, Palani Sathish Babu, John C. Mansfield, Mary-Anne Morris, Senthil V. Murugesan, Dermot P.B. McGovern, Richard Pollok, Franco Torrente, Jeffrey C. Barrett, Aleksejs Sazonovs, Aminda De Silva, George MacFaul, Paul Dunckley, Neeraj Prasad, Zahid Mahmood, Neil P. Shah, Richard Shenderey, Tariq Iqbal, Anjan Dhar, Bruce McLain, James R Goodhand, Anita Modi, Daniel L. Rice, Patrick Goggin, Alka Thakur, Vinod B. Patel, Vishal Kaushik, Scott Levison, Sonia Bouri, Fraser Cummings, Emma Wesley, Anurag Agrawal, Deven Vani, Jimmy K. Limdi, Miles Parkes, David A Elphick, Mark Tighe, Nicholas M. Croft, Charlie W. Lees, Helen Matthews, B K Baburajan, Andrew Bell, Melissa A. Smith, Tariq Ahmad, Stephen Bridger, Mark Tremelling, Matthew W. Johnson, John Fell, Claire Bewshea, Bim Bhaduri, Julie Doherty, Sean Weaver, Ben Colleypriest, Chuka U. Nwokolo, John de Caestecker, Richard K. Russell, Stuart Bloom
Publikováno v:
2020, ' HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease ', Gastroenterology, vol. 158, no. 1, pp. 189-199 . https://doi.org/10.1053/j.gastro.2019.09.041
BACKGROUND & AIMS: Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to identify pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24124ba5a4463940336ceef1408fceec
https://hdl.handle.net/20.500.11820/48abbae6-a739-4da4-9ca4-88c2ccd14323
https://hdl.handle.net/20.500.11820/48abbae6-a739-4da4-9ca4-88c2ccd14323
Autor:
Sebastian Zöllner, Mark Reppell
Publikováno v:
Theoretical Population Biology. 122:57-66
Coalescent simulations are a widely used approach for simulating sample genealogies, but can become computationally burdensome in large samples. Methods exist to analytically calculate a sample's expected frequency spectrum without simulating full ge
Autor:
Simeng Lin, Mark Reppell, Neil Chanchlani, Heath Guay, M W Anderson, Nicholas A. Kennedy, James R Goodhand, B M Invergo, Tariq Ahmad, J W Butler
Publikováno v:
Journal of Crohn's and Colitis. 14:S067-S068
Background Proteomic biomarkers have been linked to anti-TNF treatment failure, but previous studies have been insufficiently powered to stratify associations by drug level. The Personalised Anti-TNF Therapy in Crohn’s disease (PANTS) is a prospect
Autor:
Daniel L. Rice, Graham A. Heap, Tariq Ahmad, Gareth J. Walker, Miles Parkes, Charlie W. Lees, Carl A. Anderson, Dermot P.B. McGovern, John C. Mansfield, Nicholas A Kennedy, Jeffrey C. Barrett, Mandy H Perry, Timothy J. McDonald, James R Goodhand, Loukas Moutsianas, Aleksejs Sazonovs, Mark Reppell, Fraser Cummings, Claire Bewshea
SummaryBackgroundAnti-tumour necrosis factor (anti-TNF) therapies are the most widely used biologic therapies for treating immune-mediated diseases. Their efficacy is significantly reduced by the development of anti-drug antibodies which can lead to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fa0b90ae34998c993eebd5060946c5
Publikováno v:
Genetics. 196:819-828
Current human sequencing projects observe an abundance of extremely rare genetic variation, suggesting recent acceleration of population growth. To better understand the impact of such accelerating growth on the quantity and nature of genetic variati
Publikováno v:
Genome Biology
A report on the 64th annual American Society of Human Genetics meeting held in San Diego, USA, 18-22 October, 2014.
Autor:
Matthew R. Nelson, Margaret G. Ehm, Sebastian Zöllner, Mark Reppell, Matthew Zawistowski, Daniel Wegmann, John Novembre, Pamela L. St. Jean
Publikováno v:
European journal of human genetics : EJHG. 22(9)
There is substantial interest in the role of rare genetic variants in the etiology of complex human diseases. Several gene-based tests have been developed to simultaneously analyze multiple rare variants for association with phenotypic traits. The te
Summary: Recent genetic studies as well as recorded history point to massive growth in human population sizes during the recent past. To model and understand this growth accurately we introduce FTEC, an easy-to-use coalescent simulation program capab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4499c5b034226a1f429c402a1d2ea88
https://europepmc.org/articles/PMC3338023/
https://europepmc.org/articles/PMC3338023/