Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mark R.E. Coyne"'
Autor:
Kate O'Mahony, Chandan D'Souza, Shane Toolan, Niall Swan, Joy Lewis, Joan Marie Fitzgerald, Kamal Fadalla, Daniel G Connaghan, Karen Murphy, Mark R.E. Coyne, Conor D. Collins, Mark Griffin, Liam Smyth, Gibbons David, Crotty Tom
Publikováno v:
Blood. 136:37-38
Introduction The introduction of novel therapies has significantly improved outcomes in myeloma. However, the economic burden of enhanced healthcare utilization is significant and cannot be discounted. This study sought to identify baseline character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d830c54fb82477445a92d30d231ceae9
https://doi.org/10.1182/blood-2020-138857
https://doi.org/10.1182/blood-2020-138857
Autor:
Giao Le, Paul Dowling, Peter O'Gorman, Jonathan Bones, Mark R.E. Coyne, Annemarie Larkin, Despina Bazou
Publikováno v:
Molecular omics. 15(1)
Multiple myeloma, an incurable malignancy of the plasma cells in the bone marrow, has a complex pathogenesis due to clonal heterogeneity. Over the years, many clinical trials and researches have led to the development of effective myeloma treatments,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9730267bdb697e69c4dfe44bbb755e
https://pubmed.ncbi.nlm.nih.gov/30652172
https://pubmed.ncbi.nlm.nih.gov/30652172
Autor:
Janet A. Gilbertson, David F. Hutt, Candida Cristina Quarta, Mark R.E. Coyne, Taryn Youngstein, Tamer Rezk, Helen J. Lachmann, Philip N. Hawkins, Nicholas J. Goddard, Julian D. Gillmore, Richa Manwani, Huw Beynon
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 69(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32816c935ccc19910c2dd7ceb369e435
https://pubmed.ncbi.nlm.nih.gov/28556554
https://pubmed.ncbi.nlm.nih.gov/28556554
Autor:
B. Paul Wordsworth, Gordon W. Duff, Andrei Calin, Owen Beynon, Aaron Abbott, Anne Marie Sims, A. M. Crane, Linda A. Bradbury, Ibi Herzberg, Heather J. Cordell, Andrew E. Timms, Lon R. Cardon, Matthew A. Brown, Mark R.E. Coyne
Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ea5a91180a015f6cc2d73742819a86
https://doi.org/10.1086/424695
https://doi.org/10.1086/424695
Autor:
Patrick Hayden, Kathleen Scott, Brian Hennessy, Jacinta Marron, Jacob P. Laubach, Paul G. Richardson, Orna Harraghy, Hilary O'Leary, Gerard Crotty, Meegahage Ratnakanthi Perera, Janusz Krawczyk, Lourdes del Rosario McAlester, Philip Murphy, Elizabeth Lenihan, John Quinn, Mark R.E. Coyne, K. Egan, Michael O'Dwyer, Elizabeth Coghlan, Imelda Parker, Oonagh Gilligan, Orlaith Cormican, Michele Cunnane, Aoife Connell, Peter O'Gorman
Publikováno v:
Blood. 128:2117-2117
Introduction: Lenalidomide, bortezomib and dexamethasone (RVD) is considered a new standard of care regimen for patients with newly diagnosed multiple myeloma. A previous phase I/II study of RVD in front-line myeloma enrolled 66 patients and achieved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc97f05a39e97e6dee0a995e2aafdf99
https://doi.org/10.1182/blood.v128.22.2117.2117
https://doi.org/10.1182/blood.v128.22.2117.2117
Autor:
Michael O'Dwyer, Gemma O'Brien, Alessandro Natoni, Sandra Healy, Corrado Santocanale, Alan Jacobsen, Alessia Montagnoli, Jürgen Moll, Mark R.E. Coyne, Michael D. Rainey
Publikováno v:
Cancers
Cancers; Volume 5; Issue 3; Pages: 901-918
Cancers, Vol 5, Iss 3, Pp 901-918 (2013)
Cancers; Volume 5; Issue 3; Pages: 901-918
Cancers, Vol 5, Iss 3, Pp 901-918 (2013)
Two key features of myeloma cells are the deregulation of the cell cycle and the dependency on the expression of the BCL2 family of anti-apoptotic proteins. The cell division cycle 7 (CDC7) is an essential S-phase kinase and emerging CDC7 inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36646ea83cfe44edf0f792236c9da8af
https://pubmed.ncbi.nlm.nih.gov/24202326
https://pubmed.ncbi.nlm.nih.gov/24202326
Autor:
Sarah Worthington, Mark R.E. Coyne, Paul D. Griffiths, Ashutosh D. Wechalekar, Dunnya De-Silva, Isobel Ramsay
Publikováno v:
Blood. 126:4259-4259
Background Bortezomib (Velcade®) is an inhibitor of the 26S proteasome used as a first line therapy for multiple myeloma, for retreatment of relapsed multiple myeloma and for treatment of AL amyloidosis. An increased incidence of reactivation of her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f540b831ef9ab03766c31db50e32f94
https://doi.org/10.1182/blood.v126.23.4259.4259
https://doi.org/10.1182/blood.v126.23.4259.4259
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 15:e185
The identification of Minimal Residual Disease (MRD) is becoming increasingly important for defining outcomes in haematological malignancies; particularly in independently predicting prognosis in myeloma. The role of MRD analysis in systemic AL amylo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a08ea69f22b42ba0496ef44cfd8e8dcd
https://doi.org/10.1016/j.clml.2015.07.412
https://doi.org/10.1016/j.clml.2015.07.412
Autor:
Taryn Youngstein, Shameem Mahmood, Philip N. Hawkins, A.D. Wechalekar, Darren Foard, Julian D. Gillmore, Helen J. Lachmann, Mark R.E. Coyne, Ashutosh D. Wechalekar, M Fontana, Carol J. Whelan, Thirusha Lane
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 15:e60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e4b919ee5c3cab97c5427f5489917d5
https://doi.org/10.1016/j.clml.2015.07.201
https://doi.org/10.1016/j.clml.2015.07.201
Autor:
Ashutosh D. Wechalekar, Cristina Quarta, Carol J. Whelan, Ketna Patel, K. Gomez, Mark R.E. Coyne, Julian D. Gillmore, Sajitha Sachchithanantham, Rabya Sayed, Taryn Youngstein, Helen J. Lachmann, Thirusha Lane, Darren Foard, Shameem Mahmood, Philip N. Hawkins, A. Riddle, Marianna Fontanna
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 15:e201
PO-206 Bleeding diathesis and prothrombotic tendencies in patients with newly diagnosed systemic light chain Amyloidosis: important clinical implications S. Mahmood, A. Riddle, S. Sachchithanantham, T. Lane, D. Foard, T. Youngstein, R. Sayed, K. Pate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f077c6355fe1a2a453278ac5fc82e64f
https://doi.org/10.1016/j.clml.2015.07.439
https://doi.org/10.1016/j.clml.2015.07.439