Výsledky vyhledávání - "Mark R. Spaller"

Role of PLEXIND1/TGFβ Signaling Axis in Pancreatic Ductal Adenocarcinoma Progression Correlates with the Mutational Status of KRAS

Autor: Enfeng Wang, Debabrata Mukhopadhyay, Vijay Sagar Madamsetty, Yan W. Asmann, Thomas R. Caulfield, Shamit K. Dutta, Alexandre A. Pletnev, Mark R Spaller, David K. Chang, Rosanna Upstill-Goddard, Sneha Vivekanandhan, Ramcharan Singh Angom

Publikováno v: Cancers
Volume 13
Issue 16
Cancers, Vol 13, Iss 4048, p 4048 (2021)

Simple Summary Pancreatic cancer is among the most lethal cancers. The expression of PLEXIND1, a receptor, is upregulated in many cancers (including pancreatic cancer). Traditionally, PLEXIND1 is known to be involved in neuron development and mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4467dbd6832447cf3c8450fb12edd273

Zobrazit plný text záznamu

Akademický článek

GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways.

Autor: Santanu Bhattacharya, Krishnendu Pal, Anil K Sharma, Shamit K Dutta, Julie S Lau, Irene K Yan, Enfeng Wang, Ahmed Elkhanany, Khalid M Alkharfy, Arunik Sanyal, Tushar C Patel, Suresh T Chari, Mark R Spaller, Debabrata Mukhopadhyay

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114409 (2014)

GAIP interacting protein C terminus (GIPC) is known to play an important role in a variety of physiological and disease states. In the present study, we have identified a novel role for GIPC as a master regulator of autophagy and the exocytotic pathw

Externí odkaz: https://doaj.org/article/09280cc855094a579ee67ad2cb4917df

Zobrazit plný text záznamu

Akademický článek

Chemically modified peptide scaffolds target the CFTR-associated ligand PDZ domain.

Autor: Jeanine F Amacher, Ruizhi Zhao, Mark R Spaller, Dean R Madden

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e103650 (2014)

PDZ domains are protein-protein interaction modules that coordinate multiple signaling and trafficking pathways in the cell and that include active therapeutic targets for diseases such as cancer, cystic fibrosis, and addiction. Our previous work cha

Externí odkaz: https://doaj.org/article/6c4920efa01548feb47511f22800aca3

Zobrazit plný text záznamu

Reducing dermal exposure to agrochemical carcinogens using a fluorescent dye-based intervention among subsistence farmers in rural Honduras

Autor: Gregory J. Tsongalis, Mark R. Spaller, Megan E. Romano, Suyapa Bejarano, Zhongze Li, Karen L. Huyck, Mark A Cervinski, Thomas G. Flynn, Kathleen Doyle Lyons, Charlene M. Dunaway, Linda S. Kennedy, Ethan P. M. LaRochelle

Publikováno v: International journal of hygiene and environmental health. 234

Background Occupational exposure to agrochemicals, some of which are known or suspected carcinogens, is a major health hazard for subsistence agricultural workers and their families. These impacts are more prevalent in low-and-middle income countries

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e29e36c4796ce2223adf5380436b32
https://pubmed.ncbi.nlm.nih.gov/33799075

Zobrazit plný text záznamu

Interaction between CRIPT and PSD-95 is required for proper dendritic arborization in hippocampal neurons

Autor: Anton Omelchenko, Joshua A. Roshal, Heidi M Chapman, Harita Menon, Tiffany L. Wang, Gaurav Kumar, Eduardo R. Martinez-Montes, Sarah G. Donofrio, Bonnie L. Firestein, Mark R. Spaller

Publikováno v: Mol Neurobiol

CRIPT, the cysteine-rich PDZ-binding protein, binds to the third PDZ domain of PSD-95 (postsynaptic density protein 95) family proteins and directly binds microtubules, linking PSD-95 family proteins to the neuronal cytoskeleton. Here, we show that o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b570b7dd8b40d7061c1e8501001a2a
https://europepmc.org/articles/PMC7176523/

Zobrazit plný text záznamu

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models

Publikováno v: NATURE NEUROSCIENCE
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname

Dyshomeostasis of amyloid-β peptide (Aβ) is responsible for synaptic malfunctions leading to cognitive deficits ranging from mild impairment to full-blown dementia in Alzheimer's disease. Aβ appears to skew synaptic plasticity events toward depres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5f5cabb78039676dfeceea2eba5fb1
https://doi.org/10.1038/nn.4225

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání