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pro vyhledávání: '"Mark R. Seggel"'
Autor:
Mark R. Seggel, Kenner C. Rice, F. Ivy Carroll, Arthur E. Jacobson, Richard B. Rothman, George A. Brine, Heng Xu
Publikováno v:
Life Sciences. 48:PL111-PL116
The objective of this study was to determine the binding affinities of (±)-cis-N-[1-(2-hydroxy-2- phenylethyl)-3-methyl-4-piperidyl]-N-phenylpropanamide-HCI (RTI-4614-4), which is an analog of (+)-cis-3-methylfentanyl for opioid receptor subtypes. T
Autor:
Milt Titeler, Robert A. Lyon, M. Y. Yousif, Mark R. Seggel, Richard A. Glennon, Eva A. Suba, Bryan L. Roth
Publikováno v:
Journal of Medicinal Chemistry. 33:1032-1036
With [SH]ketanserin as the radioligand, structureaffinity relationships (SAFIRs) for binding at central 5HTz serotonin receptors (rat frontal cortex) were examined for a series of 27 4-substituted 1-(2,5dimethoxypheny1)-2-aminopropane derivatives (2,
Publikováno v:
European journal of pharmacology. 229(2-3)
Pigeon cerebrospinal fluid was assayed for 5-HT (5-hydroxytryptamine) and catecholamine metabolites after systemic drug injection. The 5-HT 1 -like receptor agonist 8-hydroxy-(di-n-propylamino)tetralin (8-OH-DPAT), 5-methoxy-3(1,2,3,6-tetrahydropyrid
Publikováno v:
European Journal of Pharmacology. 145:291-297
Twenty-one indolealkylamines, some of which are known to be psychoactive in man, were examined for their binding interactions with rat brain cortical 5-HT2 receptors labeled with the antagonist radioligand [3H]ketanserin in order to develop structure
Publikováno v:
Life Sciences. 41:1077-1081
The effects of the 5-HT2-sselective agonists 1-(4-bromo-2, 5-dimethoxyphenyl) -2- aminopropane (DOB) and 1- (2, 5-dimethenyl4-iodophenyl) -2- aminopropane (DOI) on cat platelet aggregation were investigated and compared with those produced by seroton
Publikováno v:
Journal of Medicinal Chemistry. 30:930-932
1-(4-Bromo-2,5-dimethoxyphenyl)-2-aminopropane (DOB) is a serotonin (5-HT) agonist that displays a high affinity and selectivity for a certain population of central 5-HT binding sites (i.e., 5-HT2 sites). In the present study, (a) an enantiomeric pot
Autor:
William H. Soine, Robert A. Lyon, Milt Titeler, Katherine Herrick-Davis, Mark R. Seggel, Richard A. Glennon
Publikováno v:
Journal of medicinal chemistry. 31(1)
Publikováno v:
ChemInform. 18
1-(4-Bromo-2,5-dimethoxyphenyl)-2-aminopropane (DOB) is a serotonin (5-HT) agonist that displays a high affinity and selectivity for a certain population of central 5-HT binding sites (i.e., 5-HT2 sites). In the present study, (a) an enantiomeric pot
Autor:
Mark R. Seggel, Richard A. Glennon
Publikováno v:
ACS Symposium Series ISBN: 9780841217027
Probing Bioactive Mechanisms
Probing Bioactive Mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0cd76809bb2744acebe5087c20ca514
https://doi.org/10.1021/bk-1989-0413.ch018
https://doi.org/10.1021/bk-1989-0413.ch018
Autor:
PHILP S. MAGEE, DOUGLAS R. HENRY, JOHN H. BLOCK, Philip S. Magee, Renee L. DesJarlais, George L. Seibel, Irwin D. Kuntz, A. Morrie Craig, Arthur M. Doweyko, Takaaki Nishioka, Kazuo Sumi, Jun'ichi Oda, Barry K. Lavine, Anthony J. I. Ward, Jian Hwa Han, Orla Donoghue, Hiroki Ohta, Noburo Kyomura, Yoji Takahashi, E. L. Plummer, J. A. Dixson, R. M. Kral, András Székács, Barna Bordás, György Matolcsy, Bruce D. Hammock, Yasuyuki Kurita, Kazunori Tsushima, Chiyozo Takayama, Hugh D. Sisler, Nancy N. Ragsdale, W. Draber, B. Pittel, A. Trebst, T. F. Murray, T. A. Blair, M. Leid, P. H. Franklin, J. F. Siebenaller, Mark E. Goldman, Michael Rosenblatt, Richard A. Glennon, Mark R. Seggel, James W. King, William A. Denny, William R. Wilson, Brian D. Palmer, Yupei Yu, Arie Verloop, U. Rickenbacher, S. Jordan, J. D. McKinney, Robert L. Lipnick