Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mark R. Rauckhorst"'
Autor:
Jeremy T. Starr, Veerabahu Shanmugasundaram, Sandra P. McCurdy, Michael D. Huband, Lisa Aschenbrenner, Brian S. Gerstenberger, Eric B. McElroy, M. Megan Lemmon, Mark R. Rauckhorst, Seungil Han, Andrew P. Tomaras, Ye Che, Nicole Caspers, Jennifer A. Young, Richard P. Zaniewski, John D. Knafels, Matthew Frank Brown, Chao Li
Publikováno v:
Journal of Medicinal Chemistry. 57:3845-3855
Multidrug-resistant Gram-negative pathogens are an emerging threat to human health, and addressing this challenge will require development of new antibacterial agents. This can be achieved through an improved molecular understanding of drug-target in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378ef2f088e44507ee22d24693c40c14
https://doi.org/10.1021/jm500219c
https://doi.org/10.1021/jm500219c
Autor:
Hongliang Cai, Mark Tomilo, Sandra P. McCurdy, Jeremy T. Starr, Manjinder S. Lall, Mandy Lockard, Mark R. Rauckhorst, Jeffrey W. Gage, Barbachyn Michael R, Huifen Chen, Robert M. Owen, Michael D. Huband, Debra Hanna, Lisa Mullins, Richard J. Sciotti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5302-5306
Dual inhibitors of bacterial gyrB and parE based on a 5-(2-pyrimidinyl)-imidazo[1,2-a]pyridine template exhibited MICs (microg/mL) of 0.06-64 (Sau), 0.25-64 (MRSA), 0.06-64 (Spy), 0.06-64 (Spn), and 0.03-64 (FQR Spn). Selected examples were efficacio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0e2071aabace46a4d35df913c184d5
https://doi.org/10.1016/j.bmcl.2009.07.141
https://doi.org/10.1016/j.bmcl.2009.07.141
Publikováno v:
Organic Letters. 11:2097-2100
A simple one-pot method for the synthesis of diversely functionalized pyrazoles from aryl nucleophiles, di-tert-butylazodicarboxlate, and 1,3-dicarbonyl or equivalent compounds is presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fafe40f54dc04a1b9a1eb626419be0
https://doi.org/10.1021/ol900515a
https://doi.org/10.1021/ol900515a
Autor:
Mark R. Rauckhorst, Jeffrey W. Corbett, Lawrence W. Fitzgerald, Christopher S. Knauer, Fang Qian, Robert Louis Hoffman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6250-6256
Low nanomolar corticotropin releasing factor type-1 (CRF(1)) receptor antagonists containing unique indanylamines were identified from the heteroatom-linked pyrazine chemotype. The most potent indanylpyrazine had a K(i)=11+/-1 nM. The oxygen-linked p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fe84b95d3bbdea13266b0b3d540767
https://doi.org/10.1016/j.bmcl.2007.09.008
https://doi.org/10.1016/j.bmcl.2007.09.008
Publikováno v:
ChemInform. 40
A simple one-pot method for the synthesis of diversely functionalized pyrazoles from aryl nucleophiles, di-tert-butylazodicarboxlate, and 1,3-dicarbonyl or equivalent compounds is presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30e4b1915b8033cd0ff1cb7343d00a4a
https://doi.org/10.1002/chin.200940111
https://doi.org/10.1002/chin.200940111
Autor:
Tong Zhu, Guo Liang Lu, Amy M. Ottolini, Freddy Rivault, Keith R. Marotti, Chris Limberakis, Themis E. Joannides, Clarke Taylor, Adrian Blaser, William A. Denny, Murphy Sean T, Mark R. Rauckhorst, Edmund L. Ellsworth, Jeremy T. Starr, Heather L. Case, Michael Stier, Susan Elizabeth Hagen, Jeff B. Smaill, Michael D. Huband
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(8)
Several novel series of nitrile-containing fluoroquinolones with weakly basic amines are reported which have reduced potential for hERG (human ether-a-go-go gene) channel inhibition as measured by the dofetilide assay. The new fluoroquinolones are po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d832ff60b0a9bafd7b243a37d4ea35
https://pubmed.ncbi.nlm.nih.gov/17303420
https://pubmed.ncbi.nlm.nih.gov/17303420
Publikováno v:
ChemInform. 34
Chiral intramolecularly hydrogen-bonded dendrons that fold into a dynamically biased helical conformation can be ‘locked’ in kinetically controlled conformations by coordination to copper(II) metal centers. Covalent bonding of each pyridine-2,6-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3fe3747a851e3c67dfa217f7c22a3e
https://doi.org/10.1002/chin.200333071
https://doi.org/10.1002/chin.200333071