Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Mark R. Pickard"'
Autor:
Síle M. Griffin, Mark R. Pickard, Clive P. Hawkins, Adrian C. Williams, Rosemary A. Fricker, Cesar V. Borlongan
Publikováno v:
PLoS ONE, Vol 15, Iss 9 (2020)
Emerging evidence indicates that a strong relationship exists between brain regenerative therapies and nutrition. Early life nutrition plays an important role during embryonic brain development, and there are clear consequences to an imbalance in nut
Externí odkaz:
https://doaj.org/article/d01a960f36534f12baa909cd09bba4f1
Publikováno v:
Biology, Vol 10, Iss 3, p 230 (2021)
Animal models have been used in preclinical research to examine potential new treatments for spinal cord injury (SCI), including mesenchymal stem cell (MSC) transplantation. MSC transplants have been studied in early human trials. Whether the animal
Externí odkaz:
https://doaj.org/article/733b5469401440c5a05d9a6bb0a1c7fd
Autor:
Mark R. Pickard, Gwyn T. Williams
Publikováno v:
Genes, Vol 6, Iss 3, Pp 484-499 (2015)
It is increasingly recognised that lncRNAs play essential regulatory roles in fundamental biological processes and, consequently, that their dysregulation may contribute to major human diseases, including cancer. Better understanding of lncRNA biolog
Externí odkaz:
https://doaj.org/article/6c3ef0965109418c896412805eb0120d
Publikováno v:
Journal of Functional Biomaterials, Vol 6, Iss 2, Pp 259-276 (2015)
Genetically engineered neural stem cell (NSC) transplants offer a key strategy to augment neural repair by releasing therapeutic biomolecules into injury sites. Genetic modification of NSCs is heavily reliant on viral vectors but cytotoxic effects ha
Externí odkaz:
https://doaj.org/article/e0aa69e4dfa743108b95dbddefe533b6
Autor:
Divya M. Chari, Mark R. Pickard
Publikováno v:
International Journal of Molecular Sciences, Vol 11, Iss 3, Pp 967-981 (2010)
Magnetic nanoparticles (MNPs) are important contrast agents used to monitor a range of neuropathological processes; microglial cells significantly contribute to MNP uptake in sites of pathology. Microglial activation occurs following most CNS patholo
Externí odkaz:
https://doaj.org/article/328c451f23714cb3bfcd1e5765b2bee7
Publikováno v:
PLoS ONE, Vol 15, Iss 9 (2020)
PLoS ONE, Vol 15, Iss 9, p e0233477 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0233477 (2020)
PLoS ONE
Emerging evidence indicates that a strong relationship exists between brain regenerative therapies and nutrition. Early life nutrition plays an important role during embryonic brain development, and there are clear consequences to an imbalance in nut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6124ceb7d241fa6d6644ba959e8dea98
Publikováno v:
Cellular Signalling. 28:1389-1400
Background:\ud The control of breast cell survival is of critical importance for preventing breast cancer initiation and progression. The activity of many proteins which regulate cell survival is controlled by reversible phosphorylation, so that the
Autor:
Mark R. Pickard, Gwyn T. Williams
Publikováno v:
Translational Cancer Research. 5:S564-S566
The investigation of long non-protein-coding RNAs (lncRNAs) has become a key area in biological and biomedical research. This is the result of sequencing and analysis of the human genome, which showed that only around 2% encodes proteins, together wi
Autor:
Rowan P. Orme, Adrian C. Williams, Rosemary A. Fricker, Síle M. Griffin, Clive Hawkins, Mark R. Pickard
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183358 (2017)
PLoS ONE
PLoS ONE
Introduction Vitamin B3 has been shown to play an important role during embryogenesis. Specifically, there is growing evidence that nicotinamide, the biologically active form of vitamin B3, plays a critical role as a morphogen in the differentiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2907cd94a5a0039b94fc7dd6ec3388
https://eprints.keele.ac.uk/3926/1/fricker_2017_journal.pone.0183358.pdf
https://eprints.keele.ac.uk/3926/1/fricker_2017_journal.pone.0183358.pdf
Autor:
Gwyn T. Williams, Joop Gaken, Nicola J. McCarthy, Kiren Yacqub-Usman, David Darling, Farzin Farzaneh, Mark R. Pickard, Shu Uin Gan, Aytug Kizilors, Cathleen E Schulte
Publikováno v:
Bioscience Reports
Kizilors, A, Pickard, M R, Schulte, C E, Yacqub-Usman, K, McCarthy, N J, Gan, S-U, Darling, D, Gäken, J, Williams, G T & Farzaneh, F 2017, ' Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival ', Bioscience Reports, vol. 37, no. 4, BSR20170843 . https://doi.org/10.1042/BSR20170843
Kizilors, A, Pickard, M R, Schulte, C E, Yacqub-Usman, K, McCarthy, N J, Gan, S-U, Darling, D, Gäken, J, Williams, G T & Farzaneh, F 2017, ' Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival ', Bioscience Reports, vol. 37, no. 4, BSR20170843 . https://doi.org/10.1042/BSR20170843
The E3 ubiquitin ligase RNF168 is a ring finger protein that has been previously identified to play an important regulatory role in the repair of double-strand DNA breaks. In the present study, an unbiased forward genetics functional screen in mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82b90c9ce0e3ff4d0fdd9459b2529be
https://eprints.keele.ac.uk/4119/1/BSR20170843.full.pdf
https://eprints.keele.ac.uk/4119/1/BSR20170843.full.pdf