Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Mark R. Parthun"'
The physical association of specific regions of chromatin with components of the nuclear lamina provides the framework for the 3-dimensionl architecture of the genome. The regulation of these interactions plays a critical role in the maintenance of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d9fc034670dc44156038062c1f1d74
https://doi.org/10.1101/2022.11.11.516151
https://doi.org/10.1101/2022.11.11.516151
Autor:
Mark R. Parthun, Prabakaran Nagarajan
Publikováno v:
Aging (Albany NY)
Protein N-ε-lysine acetylation is is an important post-translational modification that plays critical roles in the regulation of many cellular processes. A role for this modification in the process of aging goes back two decades to the discovery tha
Publikováno v:
J Proteome Res
Lysine acetylation has emerged as one of the most important post-translational modifications, regulating different biological processes. However, its regulation by lysine acetyltransferases is still unclear in most cases. Hat1 is a lysine acetyltrans
Autor:
Miranda L. Gardner, Mark R. Parthun, Benjamin Sunkel, Meng Wang, Prabakaran Nagarajan, Liudmila V. Popova, Michael A. Freitas, Callie M. Lovejoy, Benjamin Z. Stanton
Publikováno v:
Nucleic Acids Research
A central component of the epigenome is the pattern of histone post-translational modifications that play a critical role in the formation of specific chromatin states. Following DNA replication, nascent chromatin is a 1:1 mixture of parental and new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f964307cfc5a22898e5cc1c698ba5ae2
https://doi.org/10.1101/2021.06.28.450212
https://doi.org/10.1101/2021.06.28.450212
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e100299 (2014)
Hif1p is an H3/H4-specific histone chaperone that associates with the nuclear form of the Hat1p/Hat2p complex (NuB4 complex) in the yeast Saccharomyces cerevisiae. While not capable of depositing histones onto DNA on its own, Hif1p can act in conjunc
Externí odkaz:
https://doaj.org/article/23e289a9edef4a82ba656d199a3ac8f1
Autor:
Prabakaran Nagarajan, Zhongqi Ge, Bianca Sirbu, Cheryl Doughty, Paula A Agudelo Garcia, Michaela Schlederer, Anthony T Annunziato, David Cortez, Lukas Kenner, Mark R Parthun
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003518 (2013)
Histone acetyltransferase 1 is an evolutionarily conserved type B histone acetyltransferase that is thought to be responsible for the diacetylation of newly synthesized histone H4 on lysines 5 and 12 during chromatin assembly. To understand the funct
Externí odkaz:
https://doaj.org/article/3a836d31e30440918adce888449a9f67
Autor:
Michael A. Freitas, Prabakaran Nagarajan, Callie M. Lovejoy, Paula A. Agudelo Garcia, Dongju Park, Mark R. Parthun, Liudmila V. Popova
Publikováno v:
J Biol Chem
The replisome is a protein complex on the DNA replication fork and functions in a dynamic environment at the intersection of parental and nascent chromatin. Parental nucleosomes are disrupted in front of the replication fork. The daughter DNA duplexe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161924b2fe2b129a5d133d69fd66b93b
https://doi.org/10.1101/2020.03.17.989434
https://doi.org/10.1101/2020.03.17.989434
Publikováno v:
Nucleic Acids Research
Replication-dependent histones are expressed in a cell cycle regulated manner and supply the histones necessary to support DNA replication. In mammals, the replication-dependent histones are encoded by a family of genes that are located in several cl
Autor:
David M Lucas, Lapo Alinari, Derek A West, Melanie E Davis, Ryan B Edwards, Amy J Johnson, Kristie A Blum, Craig C Hofmeister, Michael A Freitas, Mark R Parthun, Dasheng Wang, Amy Lehman, Xiaoli Zhang, David Jarjoura, Samuel K Kulp, Carlo M Croce, Michael R Grever, Ching-Shih Chen, Robert A Baiocchi, John C Byrd
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10941 (2010)
While deacetylase (DAC) inhibitors show promise for the treatment of B-cell malignancies, those introduced to date are weak inhibitors of class I and II DACs or potent inhibitors of class I DAC only, and have shown suboptimal activity or unacceptable
Externí odkaz:
https://doaj.org/article/b8f82372d6bd484e99c19bd6510c448b
Autor:
Paula A. Agudelo Garcia, Michael E. Hoover, Prabakaran Nagarajan, Mark R. Parthun, Pei Zhang, Michael A. Freitas
Publikováno v:
Nucleic Acids Research
Histone acetyltransferase 1 (Hat1) catalyzes the acetylation of newly synthesized histone H4 at lysines 5 and 12 that accompanies replication-coupled chromatin assembly. The acetylation of newly synthesized H4 occurs in the cytoplasm and the function