Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Mark R. Jackson"'
Autor:
Hamish T. J. Gilbert, Venkatesh Mallikarjun, Oana Dobre, Mark R. Jackson, Robert Pedley, Andrew P. Gilmore, Stephen M. Richardson, Joe Swift
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Cells must be robust to the mechanical demands of their environments. Here, Gilbert et al. expose cells to high-intensity strain cycling and use proteomics to identify a protein, SUN2, that behaves as a strain-induced breakpoint that can decouple the
Externí odkaz:
https://doaj.org/article/f8f759b44d8640cea035f511934e57db
Autor:
Anthony J. Chalmers, Sidhartha A. Dongre, Katrina H. Stevenson, Mark R. Jackson, Seamus P. Caragher, Sandeep K. Chahal, Ming Y Chong, Natividad Gomez-Roman
2D and 3D GSC exhibit similar levels of CENPF positive cells and radiation response to MK-2206. A, Representative immunofluorescent images of G7 and E2 cells grown in 2D or 3D conditions for CENPF. B, Percentage of cells showing CENPF staining per fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf97b7d7dcec5018f997fa09ffeb46c
https://doi.org/10.1158/1535-7163.22510563.v1
https://doi.org/10.1158/1535-7163.22510563.v1
Autor:
Anthony J. Chalmers, Sidhartha A. Dongre, Katrina H. Stevenson, Mark R. Jackson, Seamus P. Caragher, Sandeep K. Chahal, Ming Y Chong, Natividad Gomez-Roman
Tables depicting dose modifying factors (DMF) at surviving fractions of 0.37% and 0.1% survival were calculated for each treatment combination. A, G7, E2 and R10 cells grown in 2D or 3D conditions grown in the presence of VEGF [(+) VEGF], or the abse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ab4d1313093b40b29646b4edf4509f
https://doi.org/10.1158/1535-7163.22510551.v1
https://doi.org/10.1158/1535-7163.22510551.v1
Autor:
Anthony J. Chalmers, Sidhartha A. Dongre, Katrina H. Stevenson, Mark R. Jackson, Seamus P. Caragher, Sandeep K. Chahal, Ming Y Chong, Natividad Gomez-Roman
Glioblastoma is resistant to conventional treatments and has dismal prognosis. Despite promising in vitro data, molecular targeted agents have failed to improve outcomes in patients, indicating that conventional two-dimensional (2D) in vitro models o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3017221a6ae8fa12f587dc93f4b84e87
https://doi.org/10.1158/1535-7163.c.6539649.v1
https://doi.org/10.1158/1535-7163.c.6539649.v1
Autor:
Katherine A. Vallis, Madalena Tarsounas, Tom Brown, Afaf H. El-Sagheer, Martin R. Gill, Philip A. Waghorn, Bas M. Bavelaar, Mark R. Jackson
Telomerase is expressed in the majority (>85%) of tumors, but has restricted expression in normal tissues. Long-term telomerase inhibition in malignant cells results in progressive telomere shortening and reduction in cell proliferation. Here we repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e28019c487d490888c1e3a57acc17d76
https://doi.org/10.1158/0008-5472.c.6511004.v1
https://doi.org/10.1158/0008-5472.c.6511004.v1
Autor:
Katherine A. Vallis, Madalena Tarsounas, Tom Brown, Afaf H. El-Sagheer, Martin R. Gill, Philip A. Waghorn, Bas M. Bavelaar, Mark R. Jackson
The supplementary data file contains mass spectrometry (MS) and size exclusion chromatography (SEC) data to confirm DTPA-, 111In-, and fluorophore-labeling of oligonucleotides, TRAP assay control experiments, quantification of fluorophore-oligonucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03923d9e8b7d739f4dcdf22d1291c251
https://doi.org/10.1158/0008-5472.22421717.v1
https://doi.org/10.1158/0008-5472.22421717.v1
Autor:
Charles McSharry, Megan K. L. MacLeod, Rodrigo Gutierrez-Quintana, Emer Curley, Karin Williams, Sandeep K. Chahal, Karen Strathdee, George E. Finney, Evarest Onwubiko, Angie Rupp, Katrina Stevenson, Mark R. Jackson, Anthony J. Chalmers
Publikováno v:
International Journal of Radiation Oncology, Biology, Physics
Purpose:\ud Low-dose whole lung radiotherapy (LDLR) has been proposed as a treatment for patients with acute respiratory distress syndrome associated with SARS-CoV-2 infection and clinical trials are underway. There is an urgent need for preclinical
Autor:
Lotus M Westerhof, Jonathan Noonan, Kerrie E Hargrave, Elizabeth T Chimbayo, Zhiling Cheng, Thomas Purnell, Mark R Jackson, Nicholas Borcherding, Megan KL MacLeod
Cytokine production by memory T cells is a key mechanism of T cell mediated protection. However, we have a limited understanding of the survival and secondary responses of memory T cells with cytokine producing capacities. We interrogate antigen-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64acfb41df2720cc68848f1c79c986c3
https://doi.org/10.1101/2022.12.13.520219
https://doi.org/10.1101/2022.12.13.520219
Autor:
Venkatesh Mallikarjun, Oana Dobre, Mark R. Jackson, Melissa Kidd, Jack Llewellyn, Hamish T. J. Gilbert, Stephen M. Richardson, Joe Swift
Tissues are maintained by homeostatic feedback mechanisms where cells respond to, but also modify, the chemical and mechanical properties of the surrounding extracellular matrix. Mesenchymal stem cells (MSCs) resident in the marrow niche experience a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a541fb24c7632ac229665f3bfdd7321
https://doi.org/10.1101/2022.10.09.511462
https://doi.org/10.1101/2022.10.09.511462
Autor:
Ole Tietz, Philip A. Waghorn, Robert Carlisle, Mark R. Jackson, Lei Song, Martin R. Gill, Irini Skaripa-Koukelli, Madalena Tarsounas, Bas M. Bavelaar, Sarah Able, Katherine A. Vallis
Publikováno v:
Molecular Pharmaceutics
Telomerase represents an attractive target in oncology as it is expressed in cancer but not in normal tissues. The oligonucleotide inhibitors of telomerase represent a promising anticancer strategy, although poor cellular uptake can restrict their ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc6ba5b5cd67a99da8a217626dd2550
https://ora.ox.ac.uk/objects/uuid:ef1fdf06-d47c-4d62-b7f0-c056d58b0ace
https://ora.ox.ac.uk/objects/uuid:ef1fdf06-d47c-4d62-b7f0-c056d58b0ace