Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Mark R. Emmerling"'
Autor:
Zsolt Garami, Donald J. Connor, Marek Belohlavek, Thomas G. Beach, Suzanne L. Tyas, Alex E. Roher, Tyler A. Kokjohn, Marwan N. Sabbagh, Mark R. Emmerling, Chera L. Maarouf, Linda Vedders
Publikováno v:
Alzheimer's & Dementia. 7:445-455
Background Multiple lines of evidence suggest that cardiovascular co-morbidities hasten the onset of Alzheimer’s disease (AD) or accelerate its course. Methods To evaluate the utility of cerebral vascular physical function and/or condition paramete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb6fa51a145e049c8a1d499d652fb49
https://doi.org/10.1016/j.jalz.2010.09.002
https://doi.org/10.1016/j.jalz.2010.09.002
Autor:
Tyler A. Kokjohn, Marek Belohlavek, Ian D. Daugs, Lucia I. Sue, Chera L. Maarouf, Marwan N. Sabbagh, Mark R. Emmerling, Alex E. Roher, Suzanne L. Tyas, Thomas G. Beach, Zsolt Garami
Publikováno v:
Alzheimer's & Dementia. 7:436-444
Background A substantial body of evidence collected from epidemiologic, correlative, and experimental studies strongly associates atherosclerotic vascular disease (AVD) with Alzheimer's disease (AD). Depending on the precise interrelationship between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e4f7eee93df32d940c55c776c0b885
https://doi.org/10.1016/j.jalz.2010.08.228
https://doi.org/10.1016/j.jalz.2010.08.228
Autor:
Pankaj Mehta, Bruce A. Patrick, Sangita P. Mehta, Mark R. Emmerling, Betty Fedor, Arthur J. Dalton
Publikováno v:
Neuroscience Letters. 342:155-158
Plasma amyloid beta protein 1-40 (Abeta40) and Abeta42 levels were quantitated from 28 young Down syndrome (DS) (20-40 years old), 28 age-matched controls, 32 old DS (41-65 years old) and 32 age-matched controls in a sandwich enzyme-linked immunosorb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70aa1f855989411c2dd933cf5e76f847
https://doi.org/10.1016/s0304-3940(03)00275-1
https://doi.org/10.1016/s0304-3940(03)00275-1
Autor:
Dean C. Luehrs, Sangram S. Sisodia, Alex E. Roher, Mark R. Emmerling, M. Desiree Watson, Daniel C. Brune, Tyler A. Kokjohn, Yu Min Kuo, Walter M. Kalback, Nicole Weiss, Matthias Staufenbiel, John Lopez
Publikováno v:
Biochemistry. 41:922-928
The amyloid (Abeta) peptides generated in Hsiao's APP Tg2576 transgenic (Tg) mice are physically and chemically distinct from those characteristic of Alzheimer's disease (AD). Transgenic mouse Abeta peptides were purified using sequential size-exclus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73349e873c59d201dbecca3566e70d24
https://doi.org/10.1021/bi015685+
https://doi.org/10.1021/bi015685+
Autor:
Jerome Baudry, Michael O. Chaney, Yu Min Kuo, Alex E. Roher, W. Blaine Stine, Mark R. Emmerling
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1502:31-43
In this chapter, we attempt to analyze the evolution of the amyloid-beta (Abeta) molecular structure from its inception as part of the Abeta precursor protein to its release by the secretases and its extrusion from membrane into an aqueous environmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b045d03bb20fa47c8b6b7bbf9fe2484
https://doi.org/10.1016/s0925-4439(00)00030-2
https://doi.org/10.1016/s0925-4439(00)00030-2
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1502(1):158-171
Complement proteins are integral components of amyloid plaques and cerebral vascular amyloid in Alzheimer brains. They can be found at the earliest stages of amyloid deposition and their activation coincides with the clinical expression of Alzheimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a91b7d63d01b6bbd15267f5d42d144
Autor:
Mark R. Emmerling, Michael Mullan, Alex E. Roher, Fiona Crawford, Yu Min Kuo, Tyler A. Kokjohn, Roy O. Weller
Publikováno v:
Molecular Medicine. 6:430-439
Amyloid-β (Aβ) accumulates in plaques and as cerebral amyloid angiopathy (CAA) in the brains of both Alzheimer’s disease (AD) patients and transgenic AβPPswe/tg2576 (tg2576) mice. Increasingly, evidence in humans and mice shows this process to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::533df4bcf3de805a3944d02d3a72cc16
https://doi.org/10.1007/bf03401785
https://doi.org/10.1007/bf03401785
Autor:
Charlotte Raby, Alex E. Roher, P. F. Stahel, Lori M. Evans, Katharyn Spiegel, Mark R. Emmerling, T. Kossmann, Yu Min Kuo, P. D. Mehta, M. C. Morganti-Kossmann, M. D. Watson
Publikováno v:
Annals of the New York Academy of Sciences. 903:118-122
The increased risk for Alzheimer's Disease (AD) associated with traumatic brain injury (TBI) suggests that environmental insults may influence the development of this age-related dementia. Recently, we have shown that the levels of the beta-amyloid p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693bff11fe0cc4b6588105565ced9261
https://doi.org/10.1111/j.1749-6632.2000.tb06357.x
https://doi.org/10.1111/j.1749-6632.2000.tb06357.x
Autor:
Nathalie Chevallier, Mark R. Emmerling, Alex E. Roher, Edward H. Koo, Dean C. Luehrs, Douglas Galasko, Yu Min Kuo, Walter M. Kalback, Tyler A. Kokjohn
Publikováno v:
Biochemical and Biophysical Research Communications. 268:750-756
Amyloid beta peptides are bound rapidly in the plasma complicating an accurate assessment of their in vivo abundance by immunoassay procedures. The extent of Abeta immunoassay interference was used to estimate the Abeta binding capacity of purified p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8b3a14c796cad2173b3d27ad08b08c
https://doi.org/10.1006/bbrc.2000.2222
https://doi.org/10.1006/bbrc.2000.2222
Autor:
Jolanta Krzeslowska, Janusz Frackowiak, Henryk M. Wisniewski, Mark R. Emmerling, Taraneh Haske, Kwang S. Kim, Wei Zhang, Narayan Ramakrishna, Bozena Mazur-Kolecka
Publikováno v:
Journal of Neuropathology and Experimental Neurology. 58:288-295
Canine smooth muscle cells (SMCs), cultured from amyloid-affected brain blood vessels accumulate Alzheimer amyloid-beta peptide (Abeta) intracellularly, either spontaneously or after treatment with apolipoprotein E (apoE). ApoE is codeposited with Ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46d97c0882515e1dc7112c5d4517636
https://doi.org/10.1097/00005072-199903000-00008
https://doi.org/10.1097/00005072-199903000-00008