Výsledky vyhledávání - "Mark R. Dranias"

Akademický článek

Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson’s Disease Patients

Autor: Lin Lin, Jonathan Göke, Engin Cukuroglu, Mark R. Dranias, Antonius M.J. VanDongen, Lawrence W. Stanton

Publikováno v: Cell Reports, Vol 15, Iss 11, Pp 2411-2426 (2016)

The fact that Parkinson’s disease (PD) can arise from numerous genetic mutations suggests a unifying molecular pathology underlying the various genetic backgrounds. To address this hypothesis, we took an integrated approach utilizing in vitro disea

Externí odkaz: https://doaj.org/article/82c6eb136bfd43bea69248dbc55712f3

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Automatic Detection of Learner Engagement Using Machine Learning and Wearable Sensors

Autor: Mitchell Ruble, Mark R. Dranias, Summer Rebensky, Joanna Chiang, Maria Chaparro, Brent Winslow, Meredith Carroll

Publikováno v: Journal of Behavioral and Brain Science. 10:165-178

Training can now be delivered on a large scale through mobile and web-based platforms in which the learner is often distanced from the instructor and their peers. In order to optimize learner engagement and maximize learning in these contexts, instru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c3bdb02ef1ee1c6db00d6eff0b1748a
https://doi.org/10.4236/jbbs.2020.103010

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Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson’s Disease Patients

Autor: Lawrence W. Stanton, Mark R. Dranias, Lin Lin, Antonius M.J. VanDongen, Jonathan Göke, Engin Cukuroglu

Publikováno v: Cell Reports, Vol 15, Iss 11, Pp 2411-2426 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6453780cd0206fbcf3a2ad28fc3dc92d
https://doi.org/10.1016/j.celrep.2016.05.022

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Spatiotemporal Memory Is an Intrinsic Property of Networks of Dissociated Cortical Neurons

Autor: Mark R. Dranias, Antonius M.J. VanDongen, Gokulakrishna Banumurthy, Han Ju

Publikováno v: The Journal of Neuroscience. 35:4040-4051

The ability to process complex spatiotemporal information is a fundamental process underlying the behavior of all higher organisms. However, how the brain processes information in the temporal domain remains incompletely understood. We have explored

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adde5b53c29b33273036ffea45b654b
https://doi.org/10.1523/jneurosci.3793-14.2015

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Short-Term Memory in Networks of Dissociated Cortical Neurons

Autor: Antonius M.J. VanDongen, Mark R. Dranias, Han Ju, Ezhilarasan Rajaram

Publikováno v: The Journal of Neuroscience. 33:1940-1953

Short-term memory refers to the ability to store small amounts of stimulus-specific information for a short period of time. It is supported by both fading and hidden memory processes. Fading memory relies on recurrent activity patterns in a neuronal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118ff96863ee07f66a7956c621929c07
https://doi.org/10.1523/jneurosci.2718-12.2013

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Neural dynamics underlying impaired autonomic and conditioned responses following amygdala and orbitofrontal lesions

Autor: Mark R. Dranias, Stephen Grossberg, Daniel Bullock

Publikováno v: Behavioral Neuroscience. 122:1100-1125

A neural model is presented that explains how outcome-specific learning modulates affect, decision-making, and Pavlovian conditioned approach responses. The model addresses how brain regions responsible for affective learning and habit learning inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0b5753d769157150dd49d39fe64a3c
https://doi.org/10.1037/a0012808

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Stimulus information stored in lasting active and hidden network states is destroyed by network bursts

Autor: Mark R Dranias, M. Brandon eWestover, Sydney S Cash, Antonius M.J. VanDongen

Publikováno v: Frontiers in Integrative Neuroscience, Vol 9 (2015)
Frontiers in Integrative Neuroscience

In both humans and animals brief synchronizing bursts of epileptiform activity known as interictal epileptiform discharges (IEDs) can, even in the absence of overt seizures, cause transient cognitive impairments (TCI) that include problems with perce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad7ca0dfa990b71b924c0df9fce15a3
http://journal.frontiersin.org/Journal/10.3389/fnint.2015.00014/full

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Can the apparent adaptation of dopamine neurons’ mismatch sensitivities be reconciled with their computation of reward prediction errors?

Autor: Mark R. Dranias, Eric R. Anderson, Daniel Bullock, Can Ozan Tan

Publikováno v: Neuroscience Letters. 438:14-16

According to modern reinforcement learning theories, midbrain dopamine (DA) neurons are part of an adaptive system within which learned expectations filter reward-related signals to enable computation of reward prediction errors (RPEs). Recent electr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebdb0a911a3bca0adaa84b411415496
https://doi.org/10.1016/j.neulet.2008.04.059

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Dopaminergic and non-dopaminergic value systems in conditioning and outcome-specific revaluation

Autor: Stephen Grossberg, Daniel Bullock, Mark R. Dranias

Publikováno v: Brain research. 1238

Animals are motivated to choose environmental options that can best satisfy current needs. To explain such choices, this paper introduces the MOTIVATOR (Matching Objects To Internal VAlues Triggers Option Revaluations) neural model. MOTIVATOR describ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a211a494fd4551131599f2eaa189f545
https://pubmed.ncbi.nlm.nih.gov/18674518

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