Zobrazeno 1 - 10
of 356
pro vyhledávání: '"Mark R. Boyett"'
Autor:
Claire Wilson, Min Zi, Matthew Smith, Munir Hussain, Alicia D’Souza, Halina Dobrzynski, Mark R. Boyett
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Heart failure is associated with atrioventricular (AV) node dysfunction, and AV node dysfunction in the setting of heart failure is associated with an increased risk of mortality and heart failure hospitalisation. This study aims to understand the ca
Externí odkaz:
https://doaj.org/article/a9cacd5076b54971b97dcd4a8af8d26b
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Physiological systems vary in a day-night manner anticipating increased demand at a particular time. Heart is no exception. Cardiac output is primarily determined by heart rate and unsurprisingly this varies in a day-night manner and is high
Externí odkaz:
https://doaj.org/article/c273968fb8c84a61a1ba8904335d6d83
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The cardiac hyperpolarization-activated “funny” current (If), which contributes to sinoatrial node (SAN) pacemaking, has a more negative half-maximal activation voltage and smaller fully-activated macroscopic conductance in human than in rabbit S
Externí odkaz:
https://doaj.org/article/755b4dfbd5704c50a881d6b24924d061
Autor:
Sunil Jit R. J. Logantha, Sanjay R. Kharche, Yu Zhang, Andrew J. Atkinson, Guoliang Hao, Mark R. Boyett, Halina Dobrzynski
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Abstract In adult mammalian hearts, atrioventricular rings (AVRs) surround the atrial orifices of atrioventricular valves and are hotbed of ectopic activity in patients with focal atrial tachycardia. Experimental data offering mechanistic insights in
Externí odkaz:
https://doaj.org/article/528dfa53538c4e9eb2e94d8b77e5e113
Autor:
Isabelle Bidaud, Alicia D’Souza, Gabriella Forte, Eleonora Torre, Denis Greuet, Steeve Thirard, Cali Anderson, Antony Chung You Chong, Angelo G. Torrente, Julien Roussel, Kevin Wickman, Mark R. Boyett, Matteo E. Mangoni, Pietro Mesirca
Publikováno v:
Frontiers in Physiology, Vol 11 (2021)
Background: Endurance athletes are prone to bradyarrhythmias, which in the long-term may underscore the increased incidence of pacemaker implantation reported in this population. Our previous work in rodent models has shown training-induced sinus bra
Externí odkaz:
https://doaj.org/article/2cc2c4e30f3345eab7d6fbf48727ec24
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The function of the sinoatrial node (SAN), the pacemaker of the heart, declines with age, resulting in increased incidence of sinoatrial node dysfunction (SND) in older adults. The present study assesses potential ionic mechanisms underlying age asso
Externí odkaz:
https://doaj.org/article/f2d5a13b9e18471fbe36f3877d566e78
Autor:
Azzah M. Alghamdi, Craig P. Testrow, Dominic G. Whittaker, Mark R. Boyett, Jules. C. Hancox, Henggui Zhang
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Marked age- and development- related differences have been observed in morphology and characteristics of action potentials (AP) of neonatal and adult sinoatrial node (SAN) cells. These may be attributable to a different set of ion channel interaction
Externí odkaz:
https://doaj.org/article/5dded67a1dd54e879f55f8fc710c89e5
Autor:
Shin Inada, PhD, Nitaro Shibata, MD, PhD, Michiaki Iwata, PhD, Ryo Haraguchi, PhD, Takashi Ashihara MD, PhD, Takanori Ikeda, MD, PhD, Kazuyuki Mitsui, PhD, Halina Dobrzynski, PhD, Mark R. Boyett, PhD, Kazuo Nakazawa, PhD
Publikováno v:
Journal of Arrhythmia, Vol 33, Iss 4, Pp 302-309 (2017)
Background: The atrioventricular (AV) node is the only compartment that conducts an electrical impulse between the atria and the ventricles. The main role of the AV node is to facilitate efficient pumping by conducting excitation slowly between the t
Externí odkaz:
https://doaj.org/article/9dcc83f2accc41ae96415a3f30c362a9
Autor:
Yu Zhang, Yanwen Wang, Joseph Yanni, Mohammed Anwar Qureshi, Sunil Jit R. J. Logantha, Sarah Kassab, Mark R. Boyett, Natalie J. Gardiner, Hong Sun, Frank Christopher Howarth, Halina Dobrzynski
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Cardiovascular complications are common in type 1 diabetes mellitus (TIDM) and there is an increased risk of arrhythmias as a result of dysfunction of the cardiac conduction system (CCS). We have previously shown that, in vivo, there is a decrease in
Externí odkaz:
https://doaj.org/article/fdf04a20ee5b429b86f091954f28f4c9
Autor:
Christian Pinali, Nadim Malik, J. Bernard Davenport, Laurence J. Allan, Lucy Murfitt, Mohammad M. Iqbal, Mark R. Boyett, Elizabeth J. Wright, Rachel Walker, Yu Zhang, Halina Dobryznski, Cathy M. Holt, Ashraf Kitmitto
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 5 (2017)
BackgroundHeart failure is a common secondary complication following a myocardial infarction (MI), characterized by impaired cardiac contraction and t‐tubule (t‐t) loss. However, post‐MI nano‐scale morphological changes to the remaining t‐t
Externí odkaz:
https://doaj.org/article/78d74663cfa54af9bef238c7a61d8829