Zobrazeno 1 - 10
of 944
pro vyhledávání: '"Mark R. Gilbert"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-11 (2024)
Abstract Despite being mutated in 92% of TP53 mutant cancers, how mutations on p53 isoforms affect their activities remain largely unknown. Therefore, exploring the effect of mutations on p53 isoforms activities is a critical, albeit unexplored area
Externí odkaz:
https://doaj.org/article/5366a9b27ccf491d81dd6ccae5616d55
Autor:
Jinkyu Jung, Eric L. Schneider, Wei Zhang, Hua Song, Meili Zhang, William Chou, Niranjan Meher, Henry F. VanBrocklin, Mary Helen Barcellos-Hoff, Tomoko Ozawa, Mark R. Gilbert, Daniel V. Santi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Central nervous system tumors have resisted effective chemotherapy because most therapeutics do not penetrate the blood-tumor-brain-barrier. Nanomedicines between ~ 10 and 100 nm accumulate in many solid tumors by the enhanced permeability a
Externí odkaz:
https://doaj.org/article/3d5e6d583d9c4105b0310e06048dd4f3
Autor:
Alvina Acquaye‐Mallory, Elizabeth Vera, Anna Choi, Kathleen Wall, Mark R. Gilbert, Terri S. Armstrong
Publikováno v:
Cancer Medicine, Vol 13, Iss 15, Pp n/a-n/a (2024)
Abstract Objective High self‐efficacy is associated with improved self‐care and reduced symptoms in cancer patients but has not been fully interrogated in adults with central nervous system (CNS) cancers. We aimed to identify the relationship bet
Externí odkaz:
https://doaj.org/article/fa6a3dfd80ab4e949d2ebb9976ae5704
Autor:
Herui Wang, Rogelio Medina, Juan Ye, Yaping Zhang, Samik Chakraborty, Alex Valenzuela, Ondrej Uher, Katerina Hadrava Vanova, Mitchell Sun, Xueyu Sang, Deric M. Park, Jan Zenka, Mark R. Gilbert, Karel Pacak, Zhengping Zhuang
Publikováno v:
Advanced Science, Vol 11, Iss 14, Pp n/a-n/a (2024)
Abstract Despite strides in immunotherapy, glioblastoma multiforme (GBM) remains challenging due to low inherent immunogenicity and suppressive tumor microenvironment. Converting “cold” GBMs to “hot” is crucial for immune activation and impro
Externí odkaz:
https://doaj.org/article/402be77c1897447c8a899980d3ead908
Publikováno v:
Cancer Medicine, Vol 12, Iss 16, Pp 16945-16957 (2023)
Abstract Background Clinical outcome assessments (COAs) are key to patient‐centered evaluation of novel interventions and supportive care. COAs are particularly informative in oncology where a focus on how patients feel and function is paramount, b
Externí odkaz:
https://doaj.org/article/9e0ec76aee234b0d95ff84b7dfa6b80b
Autor:
Amanda L. King, Alvina A. Acquaye-Mallory, Elizabeth Vera, Tito Mendoza, Jennifer Reyes, Macy L. Stockdill, Mark R. Gilbert, Terri S. Armstrong
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Primary brain tumor (PBT) patients experience higher levels of distress and anxiety than other solid tumor patients, particularly at the time of clinical evaluation when uncertainty about disease status is high (“scanxiety”).
Externí odkaz:
https://doaj.org/article/bbf381db329b4115b5ea6783adc0a7cb
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Cancer cell metabolism is often deregulated as a result of adaption to meeting energy and biosynthesis demands of rapid growth or direct mutation of key metabolic enzymes. Better understanding of such deregulation can provide new insights on
Externí odkaz:
https://doaj.org/article/b51e3a4f8aac47738ffab4d195646a79
Autor:
Ashish H. Shah, Sarah R. Rivas, Tara T. Doucet-O’Hare, Vaidya Govindarajan, Catherine DeMarino, Tongguang Wang, Leonel Ampie, Yong Zhang, Yeshavanth Kumar Banasavadi-Siddegowda, Stuart Walbridge, Dragan Maric, Marta Garcia-Montojo, Robert K. Suter, Myoung-Hwa Lee, Kareem A. Zaghloul, Joseph Steiner, Abdel G. Elkahloun, Jay Chandar, Deepa Seetharam, Jelisah Desgraves, Wenxue Li, Kory Johnson, Michael E. Ivan, Ricardo J. Komotar, Mark R. Gilbert, John D. Heiss, Avindra Nath
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Human endogenous retroviruses (HERVs) are ancestral viral relics that constitute nearly 8% of the human genome. Although normally silenced, the most recently integrated provirus HERV-K (HML-2) can be reactivated in certain cancers. Here, we report pa
Externí odkaz:
https://doaj.org/article/b841f1b345c0461faf2a96f0d318229b
Autor:
Dorela D. Shuboni-Mulligan, Demarrius Young, Julianie De La Cruz Minyety, Nicole Briceno, Orieta Celiku, Amanda L. King, Jeeva Munasinghe, Herui Wang, Kendra A. Adegbesan, Mark R. Gilbert, DeeDee K. Smart, Terri S. Armstrong
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Disrupted sleep, including daytime hypersomnolence, is a core symptom reported by primary brain tumor patients and often manifests after radiotherapy. The biological mechanisms driving the onset of sleep disturbances after cranial radiation
Externí odkaz:
https://doaj.org/article/e492bf7728204ef8b21e51309f999f43
Publikováno v:
Journal of Alloys and Metallurgical Systems, Vol 2, Iss , Pp 100011- (2023)
Spinodal phase separation in SMART (Self-passivating Metal Alloys with Reduced Thermo-oxidation) materials based on binary W-Cr with alloying elements Y and Zr is systematically investigated by a combination of Density Functional Theory with Cluster
Externí odkaz:
https://doaj.org/article/a687ff4790d5446eaa810f8f38aea3e2