Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Mark R. Burns"'
Autor:
Abdulkader Yassin-Kassab, Nathaniel Wang, Jackson Foley, Tracy Murray Stewart, Mark R. Burns, Robert A. Casero, Jr., R. Alex Harbison, Umamaheswar Duvvuri
Publikováno v:
Oral Oncology Reports, Vol 8, Iss , Pp 100123- (2023)
Background: Surgery and/or platinum-based chemoradiation remain standard of care for patients with head and neck squamous cell carcinoma (HNSCC). While these therapies are effective in a subset of patients, a substantial proportion experience recurre
Externí odkaz:
https://doaj.org/article/fa4cd743a30947f3b9126ba27820f186
Autor:
Aaminah Khan, Laura D. Gamble, Dannielle H. Upton, Caitlin Ung, Denise M. T. Yu, Anahid Ehteda, Ruby Pandher, Chelsea Mayoh, Steven Hébert, Nada Jabado, Claudia L. Kleinman, Mark R. Burns, Murray D. Norris, Michelle Haber, Maria Tsoli, David S. Ziegler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Diffuse intrinsic pontine glioma (DIPG) is an almost incurable malignant childhood brain tumor. Here, the authors show that the polyamine synthetic pathway is activated in DIPG and that the dual targeting of polyamine synthesis and uptake results in
Externí odkaz:
https://doaj.org/article/4116e5b63fd745dd8d4fa955d44571c8
Autor:
Susan K. Gilmour, Mark R. Burns, Adam E. Snook, Martin P. Keough, Allyson C. Shicora, Candace S. Hayes
PDF file - 668K, Central role of arginine metabolism in the immune system and its association with components of inflammatory response.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f7dd1a6a0fc7f8322b7d5036725719
https://doi.org/10.1158/2326-6066.22536733.v1
https://doi.org/10.1158/2326-6066.22536733.v1
Autor:
Susan K. Gilmour, Mark R. Burns, Adam E. Snook, Martin P. Keough, Allyson C. Shicora, Candace S. Hayes
Correcting T-cell immunosuppression may unleash powerful antitumor responses; however, knowledge about the mechanisms and modifiers that may be targeted to improve therapy remains incomplete. Here, we report that polyamine elevation in cancer, a comm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74dab0e6cb743071b8fc27096da637d6
https://doi.org/10.1158/2326-6066.c.6548218.v1
https://doi.org/10.1158/2326-6066.c.6548218.v1
Autor:
Susan K. Gilmour, Mark R. Burns, Adam E. Snook, Martin P. Keough, Allyson C. Shicora, Candace S. Hayes
PDF file - 797K, Increased macrophage infiltration in Ker/Ras tumors from mice treated with DFMO and AMXT 1501.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375168445d1c6efc1e148c43fb0d0b54
https://doi.org/10.1158/2326-6066.22536739.v1
https://doi.org/10.1158/2326-6066.22536739.v1
Autor:
Chelsea Mayoh, Mark R. Burns, Ruby Pandher, Anahid Ehteda, Michelle Haber, Laura D. Gamble, David S. Ziegler, Caitlin Ung, Dannielle Upton, Nada Jabado, Claudia L. Kleinman, Maria Tsoli, Steven Hébert, Denise M. T. Yu, Murray D. Norris, Aaminah Khan
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumor, with no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small organic polycations that are essential for DNA replication, transla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977c454c52d5077ce362074ecf9bf714
https://doi.org/10.1038/s41467-021-20896-z
https://doi.org/10.1038/s41467-021-20896-z
Autor:
Amanda J. Russell, Giovanni Perini, Stefania Purgato, André Oberthuer, Bing Liu, Federico M. Giorgi, Georgina L. Eden, Denise M. T. Yu, Sara Sarraf, Murray D. Norris, Michelle Haber, Emanuele Valli, Giorgio Milazzo, Claudia Flemming, Belamy B. Cheung, Simone Di Giacomo, Laura D. Gamble, Jamie I. Fletcher, David S. Ziegler, Toby Trahair, Sophie Allan, Glenn M. Marshall, Lin Xiao, Wendy B. London, Matthias Fischer, Michael D. Hogarty, Andrew J. Gifford, Jayne Murray, Daniel R. Carter, Alvin Kamili, Kimberley M. Hanssen, Chelsea Mayoh, Mark R. Burns
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Amplification of the MYCN oncogene is associated with an aggressive phenotype and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb20b9e495505924dcea7e7bf9a99d5
https://hdl.handle.net/10453/135528
https://hdl.handle.net/10453/135528
Autor:
Siwen Kang, Gaofeng Fan, Ruoning Wang, Ruohan Wu, Song Guo Zheng, JN Rashida Gnanaprakasam, Tingting Wang, Lingling Liu, Xuyong Chen, Yufeng Yao, Mark R. Burns
Robust and effective T cell-mediated immune responses require proper allocation of metabolic resources through metabolic pathways to sustain the energetically costly immune response. As an essential class of polycationic metabolites ubiquitously pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d53536a365d5ebfda7d96f52c345e82
https://doi.org/10.1101/2020.04.29.068759
https://doi.org/10.1101/2020.04.29.068759
Autor:
Lingling Liu, Mark R. Burns, Tingting Wang, Xuyong Chen, Yufeng Yao, Ruoning Wang, Gaofeng Fan, Siwen Kang, Ruohan Wu, JN Rashida Gnanaprakasam
Publikováno v:
Science Advances
Polyamine homeostasis determines T cell function.
Robust and effective T cell–mediated immune responses require proper allocation of metabolic resources through metabolic pathways to sustain the energetically costly immune response. As an esse
Robust and effective T cell–mediated immune responses require proper allocation of metabolic resources through metabolic pathways to sustain the energetically costly immune response. As an esse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0647bb0d962af9bee48a9107da824ed2
https://pubmed.ncbi.nlm.nih.gov/33328226
https://pubmed.ncbi.nlm.nih.gov/33328226
Autor:
Aaminah Khan, David S. Ziegler, Denise Yu, Maria Tsoli, Dannielle Upton, Laura D. Gamble, Chelsea Mayoh, Mark R. Burns, Michelle Haber, Ruby Pandher, Murray D. Norris
Publikováno v:
Neuro-Oncology
Diffuse intrinsic pontine glioma (DIPG) is an aggressive paediatric brainstem tumour, with a median survival of less than 1 year. Polyamines are intracellular polycations that control important aspects of cell growth and are often upregulated in canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bead5acce016e7d88c88e678f4d79a85
http://europepmc.org/articles/PMC8168151
http://europepmc.org/articles/PMC8168151